Primary aldosteronism as a cause of secondary osteoporosis
Open accessAbstract
Objective Patients with primary aldosteronism (PA) have a high prevalence of osteoporosis (OP) and fractures (Fx). We evaluated the presence of PA in patients admitted to our metabolic bone disease outpatient clinic. Design Study conducted on an in- and outpatient basis in a referral Italian endocrinology unit. Methods A total of 2632 patients were evaluated. 2310 were excluded because they were taking drugs known to affect bone or mineralocorticoids metabolism or were diagnosed to have a secondary cause of osteoporosis. The remaining 322 subjects (304 females, 18 males) took part in the study. Bone mineral density (BMD) and thoracic and lumbar spine vertebral morphometry were performed by dual X-ray absorptiometry. All patients were screened for PA with aldosterone-to-renin ratio. In those who had positive results, confirmatory tests were performed. Results Among 322 subjects, 213 were osteoporotics and 109 were not. PA was diagnosed in eleven out of 213 osteoporotic patients (5.2%) and one out of 109 non-osteoporotic subjects (0.9%,P = 0.066). PA was observed in the 26.1% of patients with the concomitant presence of osteoporosis, hypertension and hypercalciuria. Compared with patients without PA, patients with PA had mean values of urinary calcium excretion, 4.8 ± 2.5 mmol/day vs 7.6 ± 3.2 mmol/day,P < 0.001 and serum PTH levels, 5.4 pmol/L vs 7.3 pmol/L,P < 0.01, significantly higher. Conclusions PA should be considered among the causes of secondary OP.
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Diabetes/metabolic syndrome, renal damage, impaired bone mineral density, and osteoporosis have been reported more prevalent in AI patients with PA.
“Diabetes mellitus/metabolic syndrome (278,279), renal damage (280), impaired bone mineral density (81), and osteoporosis (264,281,282) have also been reported to be more prevalent in AI patients with PA.”
From Adrenal incidentaloma (2020) · cites this paper as [282]
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Cites
2013 ESH/ESC Guidelines for the management of arterial hypertension
Authors Task Force Members, Mancia, G., Fagard, R., Narkiewicz, K., Redon, J., Zanchetti, A., Böhm, M., Christiaens, T., Cífková, R., Backer, G. D., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht151 · Cited by 13,638 · see citing works
Vertebral fracture assessment using a semiquantitative technique
Genant, H. K., Wu, C. Y., van Kuijk, C., & Nevitt, M. C. (1993) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650080915 · Cited by 3,691 · see citing works
Funder, J. W., Carey, R. M., Fardella, C., Gomez-Sanchez, C. E., Mantero, F., Stowasser, M., Young, W. F., & Montori, V. M. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0104 · Cited by 1,554 · see citing works
MANAGEMENT OF ENDOCRINE DISEASE: Secondary osteoporosis: pathophysiology and management
Mirza, F., & CANALIS, E. M. (2015) · European Journal of Endocrinology · doi:10.1530/eje-15-0118 · Cited by 334 · see citing works
Shepherd, J. A., Schousboe, J. T., Broy, S. B., Engelke, K., & Leslie, W. D. (2015) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2015.06.013 · Cited by 281 · see citing works
New Insights Into the Pathogenesis of Idiopathic Hypercalciuria
Worcester, E. M., & Coe, F. L. (2008) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2008.01.005 · Cited by 170 · see citing works
Subclinical hypercortisolism among outpatients referred for osteoporosis.
Chiodini, I., Mascia, M. L., Muscarella, S., Battista, C., Minisola, S., Arosio, M., Santini, S. A., Guglielmi, G., Carnevale, V., & Scillitani, A. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-147-8-200710160-00006 · Cited by 162 · see citing works
Self-citationJonsson, J. R., Klemm, S. A., Tunny, T. J., Stowasser, M., & Gordon, R. D. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1225 · Cited by 154 · see citing works
Update in Primary Aldosteronism
Stowasser, M. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-3663 · Cited by 126 · see citing works
Pilz, S., Kienreich, K., Drechsler, C., Ritz, E., Fahrleitner-Pammer, A., Gaksch, M., Meinitzer, A., März, W., Pieber, T. R., & Tomaschitz, A. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2183 · Cited by 118 · see citing works
Colocalization of Glucocorticoid and Mineralocorticoid Receptors in Human Bone
Beavan, S. R., Horner, A. A., Bord, S., Ireland, D., & Compston, J. E. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.8.1496 · Cited by 104 · see citing works
Bone involvement in aldosteronism
Salcuni, A. S., Palmieri, S., Carnevale, V., Morelli, V., Battista, C., Guarnieri, V., Guglielmi, G., Desina, G., Eller-Vainicher, C., Beck-Peccoz, P., et al. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1660 · Cited by 101 · see citing works
Self-citationLoss of bone minerals and strength in rats with aldosteronism
Chhokar, V. S., Sun, Y., Bhattacharya, S. K., Ahokas, R. A., Myers, L. K., Xing, Z., Smith, R. A., Gerling, I., & Weber, K. T. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00477.2004 · Cited by 101 · see citing works
Update in Primary Aldosteronism
Stowasser, M. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1399 · Cited by 89 · see citing works
Bone health and aldosterone excess
Ceccoli, L., Ronconi, V., Giovannini, L., Marcheggiani, M., Turchi, F., Boscaro, M., & Giacchetti, G. (2013) · Osteoporosis International · doi:10.1007/s00198-013-2399-1 · Cited by 85 · see citing works
Risk of Fracture in Primary Aldosteronism: A Population-Based Cohort Study
Wu, V., Chang, C., Wang, C.-Y., Lin, Y., Kao, T., Lin, P., Chu, T., Chang, Y.-S., Chen, L., Wu, K., et al. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3033 · Cited by 81 · see citing works
Prevalence of primary aldosteronism among prehypertensive and stage 1 hypertensive subjects
Ito, Y., Takeda, R., Karashima, S., Yamamoto, Y., Yoneda, T., & Takeda, Y. (2010) · Hypertension Research · doi:10.1038/hr.2010.166 · Cited by 80 · see citing works
Fracture Risk in Men With Congestive Heart Failure
Carbone, L. D., Cross, J. D., Raza, S. H., Bush, A. J., Sepanski, R. J., Dhawan, S., Khan, B. Q., Gupta, M., Ahmad, K., Khouzam, R. N., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.03.039 · Cited by 79 · see citing works
Pedrazzoni, M., Girasole, G., Bertoldo, F., Bianchi, G., Cepollaro, C., Puente, A. D., Giannini, S., Gonnelli, S., Maggio, D., Marcocci, C., et al. (2003) · Osteoporosis International · doi:10.1007/s00198-003-1521-1 · Cited by 73 · see citing works
Self-citationDiuretics and Bone Loss in Rats With Aldosteronism
Law, P., Sun, Y., Bhattacharya, S. K., Chhokar, V. S., & Weber, K. T. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.03.055 · Cited by 72 · see citing works
Bone and Mineral Metabolism in Patients with Primary Aldosteronism
Petramala, L., Zinnamosca, L., Settevendemmie, A., Marinelli, C., Nardi, M., Concistrè, A., Corpaci, F., Tonnarini, G., Toma, G. D., & Letizia, C. (2014) · International Journal of Endocrinology · doi:10.1155/2014/836529 · Cited by 65 · see citing works
Gupta, M., Cheung, C., Hsu, Y., Demissie, S., Cupples, L. A., Kiel, D. P., & Karasik, D. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.333 · Cited by 62 · see citing works
Primary Aldosteronism as a Risk Factor for Vertebral Fracture
Notsu, M., Yamauchi, M., Yamamoto, M., Nawata, K., & Sugimoto, T. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-3206 · Cited by 51 · see citing works
Prevalence of subclinical contributors to low bone mineral density and/or fragility fracture
Eller-Vainicher, C., Cairoli, E., Zhukouskaya, V. V., Morelli, V., Palmieri, S., Scillitani, A., Beck‐Peccoz, P., & Chiodini, I. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0102 · Cited by 49 · see citing works
Self-citationMédeau, V., Moreau, F., Trinquart, L., Clemessy, M., Wémeau, J., Vantyghem, M. C., Plouin, P., & Reznik, Y. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03213.x · Cited by 47 · see citing works
Fumoto, T., Ishii, K., Ito, M., Berger, S., Schütz, G., & Ikeda, K. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.03.149 · Cited by 41 · see citing works
BONE DISEASE IN PRIMARY HYPERCALCIURIA
Giannini, S., Nobile, M., Sella, S., Carbonare, L. D., & Favus, M. J. (2005) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360590913533 · Cited by 31 · see citing works
Carnevale, V., Pipino, M., Antonacci, M., Checchia, C., D’Alessandro, V., Errico, M., Greco, A., & Varriale, A. (2005) · Journal of Endocrinological Investigation · doi:10.1007/bf03347215 · Cited by 18 · see citing works
Self-citationLasco, A., Catalano, A., Pilato, A. M. C. D., Basile, G., Mallamace, A., & Atteritano, M. (2014) · PubMed · Cited by 17 · see citing works
Loh, H. H., Kamaruddin, N. A., Zakaria, R., & Sukor, N. (2018) · Minerva Endocrinology · doi:10.23736/s0391-1977.16.02553-0 · Cited by 14 · see citing works
Heng, L. H., Kamaruddin, N. A., & Sukor, N. (2016) · Endocrine Abstracts · doi:10.1530/endoabs.41.gp5 · Cited by 2 · see citing works
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Sherlock, M., Scarsbrook, A., Abbas, A., Fraser, S., Limumpornpetch, P., Dineen, R., & Stewart, P. M. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa008 · Cited by 347 · see citing works
“Diabetes mellitus/metabolic syndrome (278,279), renal damage (280), impaired bone mineral density (81), and osteoporosis (264,281,282) have also been reported to be more prevalent in AI patients with PA. Clinical guidelines recommend screening for PA in every (AI) patient with hypertension or…”
Background
- Authors
- Salcuni, A. S., Carnevale, V., Battista, C., Palmieri, S., Eller-Vainicher, C., Guarnieri, V., Pugliese, F., Guglielmi, G., Desina, G., Minisola, S., Chiodini, I., & Scillitani, A.
- Affiliations
- 1Endocrinology Unit
- Casa Sollievo della Sofferenza (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- 4Medical Genetics Unit
- 5Radiology Unit
- Sapienza University of Rome (IT)
- Corresponding author
- Scillitani, Alfredo
- ORCID
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-11
- Volume
- 177
- Issue
- 5
- Pages
- 431-437
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2743577687
- Cited by
- 49
- References
- 31
- Citations by year
- 2026: 8 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 6 · 2020: 9 · 2019: 5 · 2018: 3
- FWCI
- 3.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Keywords
- primary aldosteronism, secondary osteoporosis, bone mineral density, aldosterone-renin ratio, hypercalciuria, urinary calcium excretion, parathyroid hormone, vertebral morphometry, hypertension, metabolic bone disease
- MeSH terms
- Aged, Cross-Sectional Studies, Female, Humans, Hyperaldosteronism, Male, Middle Aged, Osteoporosis, Patient Admission, Absorptiometry, Photon, Fractures, Bone
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