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Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity
Abstract
OBJECTIVE: Fibroblast growth factor-21 (FGF21) is a novel endocrine and paracrine regulator of metabolic homeostasis. The aim of our study was to measure its serum concentrations in patients with obesity, obesity and type 2 diabetes mellitus (T2DM) and healthy subjects (C), and to assess the changes of its circulating levels and mRNA expression after dietary and pharmacological interventions. DESIGN: We measured biochemical parameters, serum FGF21, adiponectin, leptin and insulin levels by commercial ELISA and RIA kits, and mRNA expression in the liver, subcutaneous and visceral fat by RT PCR in 26 obese patients, 11 T2DM patients and 32 control subjects. The interventions were acute hyperinsulinaemia during isoglycaemic-hyperinsulinaemic clamp, very low calorie diet (VLCD) and 3 months treatment with PPAR-alpha agonist fenofibrate. RESULTS: Baseline serum FGF21 levels were significantly higher in both obese and T2DM patients relative to healthy controls. FGF21 levels in obesity did not significantly differ from T2DM group. Both 3 weeks of VLCD and 3 months of fenofibrate treatment significantly increased FGF21 levels. FGF21 mRNA expression in visceral fat was twofold higher in obesity relative to C group, while it did not differ in subcutaneous fat. VLCD significantly increased FGF21 mRNA expression in subcutaneous fat of obesity. 3-h hyperinsulinaemia during the clamp increased FGF21 levels in T2DM but not in C group. CONCLUSION: An increase in FGF21 levels after VLCD and fenofibrate treatment may contribute to positive metabolic effect of these interventions and suggests the possibility of direct positive metabolic effects of FGF21 in humans.
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“In humans, circulating FGF21 levels also increase with obesity [[174], [175], [176]], type 2 diabetes [[176], [177], [178]], and NAFLD [179,180]”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [176]
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Cited by
Sorted by citations
Chait, A., & den Hartigh, L. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00022 · Cited by 1,529
“However, numerous additional studies have found detectable FGF21 mRNA expression in visceral WAT (157, 158), subcutaneous WAT (145, 157, 158), epicardial WAT (159), cervical adipose tissue (160, 161), and PVAT (162, 163), with the latter two depots containing both WAT and BAT.”
BackgroundBasic Mechanisms of Diabetic Heart Disease
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“Another group found an increase in serum FGF21 levels in obese individuals who followed a very low calorie diet for 3 months (16).”
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Potthoff, M. J., Kliewer, S. A., & Mangelsdorf, D. J. (2012) · Genes & Development · doi:10.1101/gad.184788.111 · Cited by 442
Metadata
- Authors
- Mraz, M., Bartlova, M., Lacinova, Z., Michalsky, D., Kasalicky, M., Haluzikova, D., Matoulek, M., Dostalova, I., Humenanska, V., & Haluzik, M.
- ORCID
- Matoulek, M.
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2009-08-14
- Volume
- 71
- Issue
- 3
- Pages
- 369-375
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2157891550
- Cited by
- 279
- References
- 27
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 12 · 2023: 17 · 2022: 14 · 2021: 19 · 2020: 19 · 2019: 17 · 2018: 13 · 2017: 18 · 2016: 15 · 2015: 26 · 2014: 27 · 2013: 16 · 2012: 21
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › GDF15 and Related Biomarkers
- Keywords
- FGF21, type 2 diabetes, obesity, visceral adipose tissue, subcutaneous adipose tissue, liver, very low calorie diet, fenofibrate, PPARα agonist, hyperinsulinemic-euglycemic clamp, adiponectin, leptin, insulin, metabolic homeostasis
- MeSH terms
- Adult, Diabetes Mellitus, Type 2, Female, Fibroblast Growth Factors, Humans, Liver, Middle Aged, Obesity, Fenofibrate, Gene Expression, Case-Control Studies, Leptin, Adiponectin
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