Cited by 576Fibroblast Growth Factor ResearchAdipose Tissue and MetabolismRegulation of Appetite and Obesity

Transgenic Mice Expressing Human Fibroblast Growth Factor-19 Display Increased Metabolic Rate and Decreased Adiposity

Tomlinson, Elizabeth, Fu, Ling, John, Linu, Hultgren, Bruce, Huang, Xiaojian, Renz, Mark, Stephan, Jean Philippe, Tsai, Saio Ping +3 more·2002·Endocrinology

Abstract

The fibroblast growth factors (FGFs), and the corresponding receptors, are implicated in more than just the regulation of epithelial cell proliferation and differentiation. Specifically, FGF23 is a regulator of serum inorganic phosphate levels, and mice deficient in FGF receptor-4 have altered cholesterol metabolism. The recently described FGF19 is unusual in that it is nonmitogenic and appears to interact only with FGF receptor-4. Here, we report that FGF19 transgenic mice had a significant and specific reduction in fat mass that resulted from an increase in energy expenditure. Further, the FGF19 transgenic mice did not become obese or diabetic on a high fat diet. The FGF19 transgenic mice had increased brown adipose tissue mass and decreased liver expression of acetyl coenzyme A carboxylase 2, providing two mechanisms by which FGF19 may increase energy expenditure. Consistent with the reduction in expression of acetyl CoA carboxylase 2, liver triglyceride levels were reduced.

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Crossref · 10.1210/endo.143.5.8850

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  • Transgenic mice overexpressing FGF-19 have increased BAT mass and reduced susceptibility to diet-induced obesity.

    “Transgenic mice overexpressing FGF-19 have increased BAT mass and reduced susceptibility to diet-induced obesity 105.”

    From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [105]

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Authors
Tomlinson, E., Fu, L., John, L., Hultgren, B., Huang, X., Renz, M., Stephan, J. P., Tsai, S. P., Powell-Braxton, L., French, D., & Stewart, T. A.
Affiliations
Genentech (US)
Corresponding author
Stewart, Timothy A.
Venue
Endocrinology
Published
2002-05-01
Volume
143
Issue
5
Pages
1741-1747
ISSN
  • 0013-7227 (ISSN-L)
  • 1945-7170
OpenAlex
W2106986971
Cited by
576
References
57
Citations by year
2026: 11 · 2025: 20 · 2024: 29 · 2023: 18 · 2022: 32 · 2021: 37 · 2020: 37 · 2019: 35 · 2018: 35 · 2017: 42 · 2016: 27 · 2015: 43 · 2014: 26 · 2013: 30 · 2012: 31
FWCI
1.97
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Genentech
  • Goddard Space Flight Center
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
FGF19, FGF receptor 4, energy expenditure, adiposity, brown adipose tissue, acetyl-CoA carboxylase 2, hepatic triglycerides, high-fat diet, obesity, diabetes mellitus, metabolic rate
MeSH terms
Fibroblast Growth Factor-23, Adipose Tissue, Animals, Body Temperature, Body Weight, Adipose Tissue, Brown, Calorimetry, Indirect, Diabetes Mellitus, Diet, Dietary Fats, Energy Metabolism, Fibroblast Growth Factors, Glucose, Glucose Tolerance Test, Humans, Liver, Mice, Transgenic, Phenotype, Mice

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