Circulating FGF-21 Levels in Normal Subjects and in Newly Diagnose Patients with Type 2 Diabetes Mellitus

Chen, W.-W.; Li, L.; Yang, G.-Y.; Li, K.; Qi, X.-Y.; Zhu, W.; Tang, Y.; Liu, H.; Boden, G.

doi:10.1055/s-2007-985148

Cited by 186Fibroblast Growth Factor ResearchAdipokines, Inflammation, and Metabolic DiseasesGDF15 and Related Biomarkers

Circulating FGF-21 Levels in Normal Subjects and in Newly Diagnose Patients with Type 2 Diabetes Mellitus

Chen, W.-W., Li, L., Yang, G.-Y., Li, K., Qi, X.-Y., Zhu, W., Tang, Y., Liu, H. +1 more·2007·Experimental and Clinical Endocrinology & Diabetes

DOI 10.1055/s-2007-985148

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Abstract

Fibroplast growth factor (FGF-21) is a recently discovered metabolic regulator. Its pathophysiologic role in humans remains unknown. In this study, we have investigated whether or not plasma FGF-21 level was different in patients with type 2 diabetes mellitus (T2DM) and non-diabetic controls. We also assessed associations between plasma FGF-21 body composition and several metabolic parameters. Fasting FGF-21 levels were significantly increased in patients with T2DM compared with controls (1.82+/-0.65 VS. 1.53+/-0.60 microg/L, P<0.05). In T2DM patients, fasting plasma FGF-21 correlate negatively with fasting blood glucose ( R= -0.31, P<0.05). Multiple regression analysis showed that FBG, plasma insulin and HOMA (IS) were independent influencing plasma FGF-21 levels. The present work suggests a potential role for FGF-21 in the pathogenesis of insulin resistance and T2DM.

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Circulating levels of FGF21 are significantly elevated in humans during type 2 diabetes, obesity, hepatosteatosis, pancreatitis, and mitochondrial dysfunction.
“Circulating levels of FGF21 are significantly elevated in humans during pathophysiological states, including type 2 diabetes (16, 18), obesity (22, 30, 93), hepatosteatosis (30, 79, 146), pancreatitis (117, 137), and mitochondrial dysfunction (78).”
From Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis (2018) · cites this paper as [18]

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Authors: Chen, W.-W., Li, L., Yang, G.-Y., Li, K., Qi, X.-Y., Zhu, W., Tang, Y., Liu, H., & Boden, G.
Affiliations: Second Affiliated Hospital of Chongqing Medical University (CN)
ORCID: Li, K.
Zhu, W.
Tang, Y.
Venue: Experimental and Clinical Endocrinology & Diabetes
Publisher: Georg Thieme Verlag KG
Published: 2007-10-09
Volume: 116
Issue: 01
Pages: 65-68
ISSN: 0947-7349 (ISSN-L)
1439-3646
DOI: 10.1055/s-2007-985148
OpenAlex: W2031514101
Cited by: 186
References: 0
Citations by year: 2025: 3 · 2024: 6 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 8 · 2019: 7 · 2018: 7 · 2017: 14 · 2016: 13 · 2015: 6 · 2014: 14 · 2013: 19 · 2012: 21
FWCI: 4.64
Type: journal article
Language: en
Open access: closed
Locations: Experimental and Clinical Endocrinology & Diabetes (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (R01-HL-0733267)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 066003, R01DK066003)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Rheumatology › GDF15 and Related Biomarkers
Keywords: FGF21, type 2 diabetes, fasting blood glucose, insulin resistance, HOMA-IR, insulin, body composition, metabolic regulation
MeSH terms: Adult, Blood Glucose, Blood Pressure, Diabetes Mellitus, Type 2, Fasting, Female, Fibroblast Growth Factors, Glycated Hemoglobin, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Regression Analysis, Triglycerides, Waist-Hip Ratio

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Circulating FGF-21 Levels in Normal Subjects and in Newly Diagnose Patients with Type 2 Diabetes Mellitus

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