Identification of a novel FGF, FGF-21, preferentially expressed in the liver

Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites

Nielsen, H., Engelbrecht, J., Brunak, S., & von HEIJNE, G. (1997) · Protein Engineering Design and Selection · doi:10.1093/protein/10.1.1 · Cited by 5,324 · see citing works

Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

Frohman, M. A., Dush, M. K., & Martin, G. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.23.8998 · Cited by 4,545 · see citing works

THE HEPARIN-BINDING (FIBROBLAST) GROWTH FACTOR FAMILY OF PROTEINS

Burgess, W. H., & Maciag, T. (1989) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.58.070189.003043 · Cited by 1,928 · see citing works

The roles of FGFs in the early development of vertebrate limbs.Preprint

Martin, G. (1998) · Genes & Development · doi:10.1101/gad.12.11.1571 · Cited by 676 · see citing works

Molecular Cloning of a Novel Cytokine cDNA Encoding the Ninth Member of the Fibroblast Growth Factor Family, which has a Unique Secretion Property

Miyamoto, M., Naruo, K., Seko, C., Matsumoto‐Yoshitomi, S., Kondo, T., & Kurokawa, T. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.7.4251-4259.1993 · Cited by 422 · see citing works

Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells.

Tanaka, A., Miyamoto, K., Minamino, N., Takeda, M., Sato, B., Matsuo, H., & Matsumoto, K. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.19.8928 · Cited by 398 · see citing works

Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.

Smallwood, P. M., Muñoz-Sanjuán, I., Tong, P. Y., Macke, J. P., Hendry, S. H. C., Gilbert, D. J., Copeland, N. G., Jenkins, N. A., & Nathans, J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9850 · Cited by 393 · see citing works

The Heparan Sulfate–Fibroblast Growth Factor Family: Diversity of Structure and Function

McKeehan, W. L., Wang, F., & Kan, M. (1997) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)61031-4 · Cited by 392 · see citing works

The fibroblast growth factor family.

Baird, A., & Klagsbrun, M. (1991) · PubMed · Cited by 322 · see citing works

Structure and Expression of the Rat mRNA Encoding a Novel Member of the Fibroblast Growth Factor Family

Yamasaki, M., Miyake, A., Tagashira, S., & Itoh, N. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.27.15918 · Cited by 288 · see citing works

Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain

Nishimura, T., Utsunomiya, Y., Hoshikawa, M., Ohuchi, H., & Itoh, N. (1999) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(98)00255-3 · Cited by 235 · see citing works

A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1

McWhirter, J. R., Goulding, M., Weiner, J. A., Chun, J. J. M., & Murre, C. (1997) · Development · doi:10.1242/dev.124.17.3221 · Cited by 231 · see citing works

Structure and Expression of a Novel Member, FGF-16, of the Fibroblast Growth Factor Family

Miyake, A., Konishi, M., Martin, F. H., Hernday, N., Ozaki, K., Yamamoto, S., Mikami, T., Arakawa, T., & Itoh, N. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8073 · Cited by 154 · see citing works

Structure and Expression of the mRNA Encoding a Novel Fibroblast Growth Factor, FGF-18

Ohbayashi, N., Hoshikawa, M., Kimura, S., Yamasaki, M., Fukui, S., & Itoh, N. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.18161 · Cited by 152 · see citing works

Keratinocyte Growth Factor: A Fibroblast Growth Factor Family Member with Unusual Target Cell Specificity

Aaronson, S. A., Bottaro, D. P., Miki, T., Ron, D., Finch, P. W., Fleming, T. P., Ahn, J., Taylor, W. G., & Rubin, J. S. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb49018.x · Cited by 151 · see citing works

Structure and Expression of a Novel Fibroblast Growth Factor, FGF-17, Preferentially Expressed in the Embryonic Brain

Hoshikawa, M., Ohbayashi, N., Yonamine, A., Konishi, M., Ozaki, K., Fukui, S., & Itoh, N. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8239 · Cited by 103 · see citing works

Expression and Possible Functions of the FGF‐5 Gene

Goldfarb, M. P., Bates, B., Drucker, B. J., Hardin, J. D., & Haub, O. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb49016.x · Cited by 39 · see citing works

The FGF6 Gene within the FGF Multigene Familya

Coulier, F., Ollendorff, V., MARKS, I., Rosnet, O., Batoz, M., Planche, J., Marchetto, S., Pébusque, M., deLAPEYRIERE, A. O., & Birnbaum, D. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb49017.x · Cited by 36 · see citing works

Expression, Processing, and Properties of int‐2

Dickson, C., Fuller-Pace, F. V., Kiefer, P., Acland, P., MacAllan, D., & Peters, G. G. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb49014.x · Cited by 36 · see citing works

Characterization of the hst‐1 Gene and Its Product

Yoshida, T., Sakamoto, H., Miyagawa, K., Sügimura, T., & Terada, M. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb49015.x · Cited by 27 · see citing works

Changing transcription start sites in H‐type α(1,2)fucosyltransferase Gene (FUT1) during differentiation of the human erythroid lineage

Koda, Y., Soejima, M., & Kimurâ, H. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2560379.x · Cited by 22 · see citing works

Mitochondria: In Sickness and in Health

Nunnari, J., & Suomalainen, A. (2012) · Cell · doi:10.1016/j.cell.2012.02.035 · Cited by 3,479 · see citing works

FGF-21 as a novel metabolic regulator

Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125 · see citing works

Fibroblast growth factors.

Ornitz, D. M., & Itoh, N. (2001) · Genome biology · doi:10.1186/gb-2001-2-3-reviews3005 · Cited by 1,985 · see citing works

The FGF family: biology, pathophysiology and therapy

Beenken, A., & Mohammadi, M. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2792 · Cited by 1,945 · see citing works

Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495 · see citing works

Crystal Structure of a Ternary FGF-FGFR-Heparin Complex Reveals a Dual Role for Heparin in FGFR Binding and Dimerization

Schlessinger, J., Plotnikov, A. N., Ibrahimi, O. A., Eliseenkova, A. V., Yeh, B. K., Yayon, A., Linhardt, R. J., & Mohammadi, M. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00073-3 · Cited by 1,199 · see citing works

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

Xu, J., Lloyd, D. J., Hale, C., Stanislaus, S., Chen, M., Sivits, G., Vonderfecht, S., Hecht, R., Li, Y.-S., Lindberg, R. A., et al. (2009) · Diabetes · doi:10.2337/db08-0392 · Cited by 1,151 · see citing works

Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk

Stern, J. H., Rutkowski, J. M., & Scherer, P. E. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.011 · Cited by 1,031 · see citing works

Fibroblast Growth Factor 21 Corrects Obesity in Mice

Coskun, T., Bina, H. A., Schneider, M. A., Dunbar, J. D., Hu, C. C., Chen, Y., Moller, D. E., & Kharitonenkov, A. (2008) · Endocrinology · doi:10.1210/en.2008-0816 · Cited by 1,031 · see citing works

Understanding the Physiology of FGF21

Fisher, F. M., & Maratos-Flier, E. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105339 · Cited by 912 · see citing works

Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans

Zhang, X., Yeung, D. C. Y., Karpisek, M., Stejskal, D., Zhou, Z.-G., Liu, F., Wong, R. L. C., Chow, W.-S., Tso, A. W. K., Lam, K. S. L., et al. (2008) · Diabetes · doi:10.2337/db07-1476 · Cited by 908 · see citing works

Molecular mechanisms of dietary restriction promoting health and longevity

Green, C. L., Lamming, D. W., & Fontana, L. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00411-4 · Cited by 714 · see citing works

Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse

Fon Tacer, K., Bookout, A. L., Ding, X., Kurosu, H., John, G. B., Wang, L., Goetz, R., Mohammadi, M., Kuro-o, M., Mangelsdorf, D. J., et al. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0142 · Cited by 700 · see citing works

FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development.

Ohuchi, H., Hori, Y., Yamasaki, M., Harada, H., Sekine, K., Kato, S., & Itoh, N. (2000) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1006/bbrc.2000.3721 · Cited by 663 · see citing works

βKlotho is required for metabolic activity of fibroblast growth factor 21

Ogawa, Y., Kurosu, H., Yamamoto, M., Nandi, A., Rosenblatt, K. P., Goetz, R., Eliseenkova, A. V., Mohammadi, M., & Kuro-o, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701600104 · Cited by 617 · see citing works

Increased Fibroblast Growth Factor 21 in Obesity and Nonalcoholic Fatty Liver Disease

Dushay, J., Chui, P. C., Gopalakrishnan, G. S., Varela–Rey, M., Crawley, M., Fisher, F. M., Badman, M. K., Martinez–Chantar, M. L., & Maratos–Flier, E. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.04.054 · Cited by 607 · see citing works

The Liver as an Endocrine Organ—Linking NAFLD and Insulin Resistance

Watt, M. J., Miotto, P. M., De Nardo, W., & Montgomery, M. K. (2019) · Endocrine Reviews · doi:10.1210/er.2019-00034 · Cited by 615 · see citing works

Identification of a Novel Fibroblast Growth Factor, FGF-23, Preferentially Expressed in the Ventrolateral Thalamic Nucleus of the Brain

Yamashita, T., Yoshioka, M., & Itoh, N. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3696 · Cited by 553 · see citing works

PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice

Wang, Y., Nakajima, T., Gonzalez, F. J., & Tanaka, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062061 · Cited by 545 · see citing works

Causes and Metabolic Consequences of Fatty Liver

Stefan, N., Kantartzis, K., & Häring, H. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0009 · Cited by 529 · see citing works

The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man

Gälman, C., Lundåsen, T., Kharitonenkov, A., Bina, H. A., Eriksson, M., Hafström, I., Dahlin, M., Åmark, P., Angelin, B., & Rudling, M. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.06.014 · Cited by 512 · see citing works

Fibroblast Growth Factor-21 Improves Pancreatic β-Cell Function and Survival by Activation of Extracellular Signal–Regulated Kinase 1/2 and Akt Signaling Pathways

Wente, W., Efanov, A. M., Brenner, M. B., Kharitonenkov, A., Koster, A. M., Sandusky, G. E., Sewing, S., Treinies, I., Zitzer, H., & Gromada, J. (2006) · Diabetes · doi:10.2337/db05-1435 · Cited by 497 · see citing works

Delivery of Neurotrophic Factors to the Central Nervous System: Pharmacokinetic Considerations

Thorne, R. G., & Frey, W. H. (2001) · Clinical Pharmacokinetics · doi:10.2165/00003088-200140120-00003 · Cited by 487 · see citing works

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

Potthoff, M. J., Kliewer, S. A., & Mangelsdorf, D. J. (2012) · Genes & Development · doi:10.1101/gad.184788.111 · Cited by 442 · see citing works

Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23

Degirolamo, C., Sabbà, C., & Moschetta, A. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.9 · Cited by 424 · see citing works

The New Biology and Pharmacology of Glucagon

Müller, T. D., Finan, B., Clemmensen, C., DiMarchi, R. D., & Tschöp, M. H. (2017) · Physiological Reviews · doi:10.1152/physrev.00025.2016 · Cited by 419 · see citing works

Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise

Schnyder, S., & Handschin, C. (2015) · Bone · doi:10.1016/j.bone.2015.02.008 · Cited by 419 · see citing works

FGF21 is an Akt‐regulated myokine

Izumiya, Y., Bina, H. A., Ouchi, N., Akasaki, Y., Kharitonenkov, A., & Walsh, K. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.10.021 · Cited by 415 · see citing works

Fibroblast growth factors and their receptors in the central nervous system

Reuß, B., & Halbach, O. V. B. U. (2003) · Cell and Tissue Research · doi:10.1007/s00441-003-0756-7 · Cited by 412 · see citing works

Functional evolutionary history of the mouse Fgf gene family

Itoh, N., & Ornitz, D. M. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21388 · Cited by 409 · see citing works

Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride

Li, H., Fang, Q., Gao, F., Fan, J., Zhou, J., Wang, X., Zhang, H., Pan, X., Bao, Y., Xiang, K., et al. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.05.018 · Cited by 400 · see citing works

Circulating Fibroblast Growth Factor-21 Is Elevated in Impaired Glucose Tolerance and Type 2 Diabetes and Correlates With Muscle and Hepatic Insulin Resistance

Chavez, A. O., Molina-Carrion, M., Abdul-Ghani, M. A., Folli, F., DeFronzo, R. A., & Tripathy, D. (2009) · Diabetes Care · doi:10.2337/dc09-0684 · Cited by 390 · see citing works

PPARα is a key regulator of hepatic FGF21

Lundåsen, T., Hunt, M., Nilsson, L.-M., Sanyal, S., Angelin, B., Alexson, S., & Rudling, M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.06.068 · Cited by 361 · see citing works

ChREBP•Mlx Is the Principal Mediator of Glucose-induced Gene Expression in the Liver

Ma, L., Robinson, L. N., & Towle, H. C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601576200 · Cited by 373 · see citing works

The endocrine function of human placenta: an overview

Costa, M. A. (2015) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2015.10.005 · Cited by 369 · see citing works

Fibroblast Growth Factor 21-Deficient Mice Demonstrate Impaired Adaptation to Ketosis

Badman, M. K., Koester, A., Flier, J. S., Kharitonenkov, A., & Maratos-Flier, E. (2009) · Endocrinology · doi:10.1210/en.2009-0532 · Cited by 362 · see citing works

Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver

Hotta, Y., Nakamura, H., Konishi, M., Murata, Y., Takagi, H., Matsumura, S., Inoue, K., Fushiki, T., & Itoh, N. (2009) · Endocrinology · doi:10.1210/en.2009-0119 · Cited by 352 · see citing works

βKlotho Is Required for Fibroblast Growth Factor (FGF) 21 Signaling through FGF Receptor (FGFR) 1c and FGFR3c

Suzuki, M., Uehara, Y., Motomura-Matsuzaka, K., Oki, J., Koyama, Y., Kimura, M., Asada, M., Komi-Kuramochi, A., Oka, S., & Toru, T. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0313 · Cited by 345 · see citing works

Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models—association with liver and adipose tissue effects

Xu, J., Stanislaus, S., Chinookoswong, N., Lau, Y. Y., Hager, T., Patel, J., Ge, H., Weiszmann, J., Lu, S.-C., Graham, M., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00348.2009 · Cited by 340 · see citing works

FGF‐21/FGF‐21 receptor interaction and activation is determined by βKlotho

Kharitonenkov, A., Dunbar, J. D., Bina, H. A., Bright, S. W., Moyers, J. S., Zhang, C., Ding, L., Micanovic, R., Mehrbod, S. F., Knierman, M. D., et al. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21357 · Cited by 329 · see citing works

The endocrine manifestations of anorexia nervosa: mechanisms and management

Haines, M. S., & Miller, K. K. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.175 · Cited by 322 · see citing works

FGF21 as Modulator of Metabolism in Health and Disease

Tezze, C., Romanello, V., & Sandri, M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00419 · Cited by 313 · see citing works

Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: A randomized controlled trial

Chen, S., Zhao, X., Ran, L., Wan, J., Wang, X., Qin, Y., Shu, F., Gao, Y., Yuan, L., Zhang, Q., et al. (2015) · Digestive and Liver Disease · doi:10.1016/j.dld.2014.11.015 · Cited by 319 · see citing works

Metabolic messengers: FGF21

Flippo, K. H., & Potthoff, M. J. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00354-2 · Cited by 311 · see citing works

Fibroblast Growth Factor 21 as an emerging metabolic regulator: clinical perspectives

Woo, Y. C., Xu, A., Wang, Y., & Lam, K. S. L. (2012) · Clinical Endocrinology · doi:10.1111/cen.12095 · Cited by 302 · see citing works

Adipose Fibroblast Growth Factor 21 Is Up-Regulated by Peroxisome Proliferator-Activated Receptor γ and Altered Metabolic States

Muise, E. S., Azzolina, B., Kuo, D. W., El-Sherbeini, M., Tan, Y., Yuan, X., Mu, J., Thompson, J. R., Berger, J. P., & Wong, K. K. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.044826 · Cited by 294 · see citing works

Exercise and dietary intervention ameliorate high-fat diet-induced NAFLD and liver aging by inducing lipophagy

Gao, Y., Zhang, W., Zeng, L.-Q., Bai, H., Li, J., Zhou, J., Zhou, G., Fang, C., Wang, F., & Qin, X.-J. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101635 · Cited by 293 · see citing works

Acute Exercise Induces FGF21 Expression in Mice and in Healthy Humans

Kim, K. H., Kim, S. H., Min, Y.-K., Yang, H.-M., Lee, J.-B., & Lee, M.-S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063517 · Cited by 290 · see citing works

The fasting polypeptide FGF21 can enter brain from blood

Hsuchou, H., Pan, W., & Kastin, A. J. (2007) · Peptides · doi:10.1016/j.peptides.2007.10.007 · Cited by 280 · see citing works

Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity

Mraz, M., Bartlova, M., Lacinova, Z., Michalsky, D., Kasalicky, M., Haluzikova, D., Matoulek, M., Dostalova, I., Humenanska, V., & Haluzik, M. (2009) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03502.x · Cited by 279 · see citing works

A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21

Kliewer, S. A., & Mangelsdorf, D. J. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.004 · Cited by 273 · see citing works

Fibroblast Growth Factor 21—Metabolic Role in Mice and Men

Staiger, H., Keuper, M., Berti, L., Hrabě de Angelis, M., & Häring, H.-U. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00016 · Cited by 270 · see citing works

Identification of a new fibroblast growth factor receptor, FGFR5.

Sleeman, M. A., Fraser, J. W., McDonald, M., Yuan, S.-N., White, D., Grandison, P., Kumble, K. D., Watson, J. D., & Murison, J. (2001) · Gene · doi:10.1016/s0378-1119(01)00518-2 · Cited by 284 · see citing works

Hepatokines and metabolism: Deciphering communication from the liver

Jensen-Cody, S. O., & Potthoff, M. J. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101138 · Cited by 252 · see citing works

Brown Adipose Tissue Responds to Cold and Adrenergic Stimulation by Induction of FGF21

Chartoumpekis, D. V., Habeos, I. G., Ziros, P. G., Psyrogiannis, A. I., Kyriazopoulou, V. E., & Papavassiliou, A. G. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00075 · Cited by 252 · see citing works

Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation

De Sousa-Coelho, A. L., Marrero, P. F., & Haro, D. (2012) · Biochemical Journal · doi:10.1042/bj20111748 · Cited by 246 · see citing works

Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation

Ren, Y., Zhao, H., Yin, C., Lan, X., Wu, L., Du, X., Griffiths, H. R., & Gao, D. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.873699 · Cited by 260 · see citing works

Methionine-Restricted C57BL/6J Mice Are Resistant to Diet-Induced Obesity and Insulin Resistance but Have Low Bone Density

Ables, G. P., Perrone, C. E., Orentreich, D. S., & Orentreich∥, N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051357 · Cited by 241 · see citing works

Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and disease

Itoh, N. (2010) · Cell and Tissue Research · doi:10.1007/s00441-010-1024-2 · Cited by 247 · see citing works

Dihydromyricetin improves glucose and lipid metabolism and exerts anti-inflammatory effects in nonalcoholic fatty liver disease: A randomized controlled trial

Chen, S., Zhao, X., Wan, J., Ran, L., Qin, Y., Wang, X., Gao, Y., Shu, F., Zhang, Y., Liu, P., et al. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.05.009 · Cited by 236 · see citing works

FGF21 attenuates lipolysis in human adipocytes – A possible link to improved insulin sensitivity

Arner, P., Pettersson, A., Mitchell, P. J., Dunbar, J. D., Kharitonenkov, A., & Rydén, M. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.04.038 · Cited by 234 · see citing works

FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism

Hill, C. M., Laeger, T., Dehner, M., Albarado, D. C., Clarke, B., Wanders, D., Burke, S. J., Collier, J. J., Qualls-Creekmore, E., Solon-Biet, S. M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.022 · Cited by 229 · see citing works

Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine

Keipert, S., Ost, M., Johann, K., Imber, F., Jastroch, M., van Schothorst, E. M., Keijer, J., & Klaus, S. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00330.2013 · Cited by 221 · see citing works

The Fgf Families in Humans, Mice, and Zebrafish: Their Evolutional Processes and Roles in Development, Metabolism, and Disease

Itoh, N. (2007) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.30.1819 · Cited by 224 · see citing works

Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity

Mashili, F. L., Austin, R. L., Deshmukh, A. S., Fritz, T., Caidahl, K., Bergdahl, K., Zierath, J. R., Chibalin, A., Moller, D. E., Kharitonenkov, A., et al. (2011) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1177 · Cited by 222 · see citing works

Myokines in insulin resistance and type 2 diabetes

Eckardt, K., Görgens, S. W., Raschke, S., & Eckel, J. (2014) · Diabetologia · doi:10.1007/s00125-014-3224-x · Cited by 223 · see citing works

Irisin, a Novel Myokine, Regulates Glucose Uptake in Skeletal Muscle Cells via AMPK

Lee, H. J., Lee, J. O., Kim, N., Kim, J. K., Kim, H. I., Lee, Y. W., Kim, S. J., Choi, J., Oh, Y., Kim, J. H., et al. (2015) · Molecular Endocrinology · doi:10.1210/me.2014-1353 · Cited by 219 · see citing works

Browning of the white adipose tissue regulation: new insights into nutritional and metabolic relevance in health and diseases

Machado, S. A., Pasquarelli-do-Nascimento, G., da Silva, D. S., Farias, G. R., Santos, I. D. O., Baptista, L. B., & Magalhães, K. G. (2022) · Nutrition & Metabolism · doi:10.1186/s12986-022-00694-0 · Cited by 229 · see citing works

Fibroblast growth factor 21: from pharmacology to physiology

Kliewer, S. A., & Mangelsdorf, D. J. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28449b · Cited by 219 · see citing works

Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis

BonDurant, L. D., & Potthoff, M. J. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064800 · Cited by 222 · see citing works

FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans

Søberg, S., Sandholt, C. H., Jespersen, N. Z., Toft, U., Madsen, A. L., von Holstein-Rathlou, S., Grevengoed, T. J., Christensen, K. B., Bredie, W. L. P., Potthoff, M. J., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.009 · Cited by 216 · see citing works

FGF21: An Emerging Therapeutic Target for Non-Alcoholic Steatohepatitis and Related Metabolic Diseases

Tillman, E. J., & Rolph, T. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.601290 · Cited by 209 · see citing works

Targeting nuclear receptors for the treatment of fatty liver disease

Tanaka, N., Aoyama, T., Kimura, S., & Gonzalez, F. J. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.05.011 · Cited by 212 · see citing works

Opposite alterations in FGF21 and FGF19 levels and disturbed expression of the receptor machinery for endocrine FGFs in obese patients

Gallego-Escuredo, J. M., Gómez‐Ambrosi, J., Catalán, V., Domingo, P., Giralt, M., Frühbeck, G., & Villarroya, F. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.76 · Cited by 212 · see citing works

Brown adipose tissue activity as a target for the treatment of obesity/insulin resistance

Poher, A.-L., Altirriba, J., Veyrat‐Durebex, C., & Rohner‐Jeanrenaud, F. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00004 · Cited by 213 · see citing works

The brown fat secretome: metabolic functions beyond thermogenesis

Wang, G.-X., Zhao, X.-Y., & Lin, J. D. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.03.002 · Cited by 206 · see citing works

Inventing new medicines: The FGF21 story

Kharitonenkov, A., & Adams, A. C. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2013.12.003 · Cited by 198 · see citing works

Molecular basis of bile acid-FXR-FGF15/19 signaling axis

Katafuchi, T., & Makishima, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116046 · Cited by 193 · see citing works

Molecular determinants of FGF‐21 activity—synergy and cross‐talk with PPARγ signaling

Moyers, J. S., Shiyanova, T. L., Mehrbod, F., Dunbar, J. D., Noblitt, T. W., Otto, K. A., Reifel-Miller, A. E., & Kharitonenkov, A. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20847 · Cited by 193 · see citing works

Positive and Negative Regulation of Epicardial–Mesenchymal Transformation during Avian Heart Development

Morabito, C. J., Dettman, R. W., Kattan, J., Collier, J. M., & Bristow, J. D. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0254 · Cited by 193 · see citing works

Crosstalk between adipokines and myokines in fat browning

Rodrı́guez, A., Becerril, S., Ezquerro, S., Méndez-Giménez, L., & Frühbeck, G. (2016) · Acta Physiologica · doi:10.1111/apha.12686 · Cited by 192 · see citing works

Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes

Iizuka, K., Takeda, J., & Horikawa, Y. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.07.053 · Cited by 187 · see citing works

Nrf2 Represses FGF21 During Long-Term High-Fat Diet–Induced Obesity in Mice

Chartoumpekis, D. V., Ziros, P. G., Psyrogiannis, A. I., Papavassiliou, A. G., Kyriazopoulou, V. E., Sykiotis, G. P., & Habeos, I. G. (2011) · Diabetes · doi:10.2337/db11-0112 · Cited by 184 · see citing works

Endocrine Protection of Ischemic Myocardium by FGF21 from the Liver and Adipose Tissue

Liu, S. Q., Roberts, D., Kharitonenkov, A., Zhang, B., Hanson, S., Li, Y. C., Zhang, L., & Wu, Y. (2013) · Scientific Reports · doi:10.1038/srep02767 · Cited by 179 · see citing works

Serum Levels of FGF-21 Are Increased in Coronary Heart Disease Patients and Are Independently Associated with Adverse Lipid Profile

Lin, Z., Wu, Z., Yin, X., Liu, Y., Yan, X., Lin, S., Xiao, J., Wang, X., Feng, W., & Li, X. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015534 · Cited by 179 · see citing works

Exercise increases serum fibroblast growth factor 21 (FGF21) levels

Cuevas-Ramos, D., Almeda-Valdés, P., Meza-Arana, C. E., Brito-Córdova, G., Gómez-Pérez, F. J., Mehta, R., Oseguera-Moguel, J., & Aguilar-Salinas, C. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038022 · Cited by 178 · see citing works

Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB

Yang, C., Jin, C., Li, X., Wang, F., McKeehan, W. L., & Luo, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033870 · Cited by 173 · see citing works

A splicing switch and gain-of-function mutation in FgfR2-IIIc hemizygotes causes Apert/Pfeiffer-syndrome-like phenotypes

Hajihosseini, M., Wilson, S. W., de Moerlooze, L., & Dickson, C. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.071586898 · Cited by 179 · see citing works

Expression of members of the Fgf family and their receptors during midfacial development

Bachler, M., & Neubüser, A. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00518-9 · Cited by 170 · see citing works

LY2405319, an engineered FGF21 variant, improves the metabolic status of diabetic monkeys

Adams, A. C., Halstead, C. A., Hansen, B. C., Irizarry, A. R., Martin, J. A., Myers, S. R., Reynolds, V. L., Smith, H. W., Wroblewski, V. J., & Kharitonenkov, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065763 · Cited by 169 · see citing works

Rational Design of a Fibroblast Growth Factor 21-Based Clinical Candidate, LY2405319

Kharitonenkov, A., Beals, J. M., Micanovic, R., Strifler, B. A., Rathnachalam, R., Wroblewski, V. J., Li, S., Köester, A., Ford, A. M., Coşkun, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058575 · Cited by 168 · see citing works

Role of fibroblast growth factor type 1 and 2 in carbon tetrachloride-induced hepatic injury and fibrogenesis

Yu, C., Wang, F., Jin, C., Huang, X., Miller, D. L., Basilico, C., & McKeehan, W. L. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63522-5 · Cited by 167 · see citing works

Going Back to the Biology of FGF21: New Insights

Lewis, J. E., Ebling, F. J. P., Samms, R. J., & Tsintzas, K. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.05.007 · Cited by 164 · see citing works

Adipose Organ Development and Remodeling

Cinti, S. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170042 · Cited by 187 · see citing works

Fibroblast growth factor 21 and its novel association with oxidative stress

Gómez-Sámano, M. Á., Grajales-Gómez, M., Zuarth-Vázquez, J. M., Navarro-Flores, M. F., Martínez-Saavedra, M., Juárez-León, Ó. A., Morales-García, M., Enriquez-Estrada, V. M., Gomez-Perez, F. J., & Ramos, D. C. (2016) · Redox Biology · doi:10.1016/j.redox.2016.12.024 · Cited by 164 · see citing works

Free radicals and male reproduction.

Agarwal, A. K., & Allamaneni, S. S. R. (2011) · PubMed · Cited by 154 · see citing works

Activation of the Farnesoid X Receptor Induces Hepatic Expression and Secretion of Fibroblast Growth Factor 21

Cyphert, H. A., Ge, X., Kohan, A. B., Salati, L. M., Zhang, Y., & Hillgartner, F. B. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.375907 · Cited by 162 · see citing works

Determinants of GH resistance in malnutrition

Fazeli, P. K., & Klibanski, A. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0477 · Cited by 158 · see citing works

Identification of MUP1 as a Regulator for Glucose and Lipid Metabolism in Mice

Zhou, Y., Jiang, L., & Rui, L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900754200 · Cited by 154 · see citing works

Circulating Fibroblast Growth Factor 21 Is Induced by Peroxisome Proliferator-Activated Receptor Agonists But Not Ketosis in Man

Christodoulides, C., Dyson, P., Sprecher, D., Tsintzas, K., & Karpe, F. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0111 · Cited by 153 · see citing works

REVIEW n o D

(2016)

Structure and Expression of the Rat mRNA Encoding a Novel Member of the Fibroblast Growth Factor Family

Yamasaki, M., Miyake, A., Tagashira, S., & Itoh, N. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.27.15918 · Cited by 288 · see citing works

Identification of a Novel Fibroblast Growth Factor, FGF-23, Preferentially Expressed in the Ventrolateral Thalamic Nucleus of the Brain

Yamashita, T., Yoshioka, M., & Itoh, N. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3696 · Cited by 553 · see citing works

FGF21

Cheng, T. W., & Leung, P. S. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4_101992 · Cited by 1 · see citing works

Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle

Nakatake, Y., Hoshikawa, M., Asaki, T., Kassai, Y., & Itoh, N. (2001) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(00)00302-x · Cited by 77 · see citing works