The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Subclinical hypercortisolism: correlation between biochemical diagnostic criteria and clinical aspects
Abstract
OBJECTIVE: Subclinical hypercortisolism (SH) has been associated with increased prevalence of hypertension, type 2 diabetes mellitus, dyslipidaemia, central obesity, osteoporosis and vertebral fractures. We aimed to investigate the accuracy of different SH diagnostic criteria in predicting the presence of complications. DESIGN: This was a retrospective study. PATIENTS: We evaluated data from 231 patients (120 women and 111 men) affected with adrenal incidentalomas (AI). MEASUREMENTS: We studied the accuracy of different SH diagnostic criteria (cortisol after 1 mg overnight dexamethasone suppression test - 1mg-DST - at different cut-off such as 49.7, 82.8, 137.9 nmol/l, elevated urinary free cortisol, reduced adrenal corticotroph hormone (ACTH) levels alone or various combination of these parameters) in predicting the concomitant presence of the following three complications: hypertension, type 2 diabetes and vertebral fractures. RESULTS: The criterion characterized by the presence of two of 1mg-DST >82.8 nmol/l, elevated UFC and reduced ACTH struck the best balance between sensitivity and specificity, reaching a good accuracy in predicting the cluster of complications (61.9%; 77.1% and 75.8%, respectively). The presence of this cluster was associated with this criterion (OR 4.75, 95%CI 1.8-12.7, P = 0.002) regardless of gonadal status, body mass index (BMI) and age. CONCLUSIONS: The SH criterion characterized by the presence of two of 1mg-DST >82.8 nmol/l, elevated UFC and reduced ACTH seems the best in predicting the presence of chronic manifestations of subtle cortisol excess.
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In the citing paper
“Overall, DM or IGT was identified in % to % of patients with AI and SCS and was related to patients' age (), the size of their adenomas, their midnight cortisol level, and their plasma cortisol level after suppression with dexamethasone ().”
From Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management (2017) · cites this paper as [211]
In the citing paper
“Focusing on glucose metabolism, the prevalence of IGT or DM has been higher in patients with SCS than in cases of nonfunctioning adenoma or controls (, , , , , , ), but these data were not confirmed by other studies that found much the same prevalence of these comorbidities in SCS as in the overall series of AI and in the general population (, -).”
From Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management (2017) · cites this paper as [211]
In the citing paper
“A chronic mild cortisol secretion abnormality may be associated with classic metabolic and cardiovascular complications of hypercortisolism (, -).”
From Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management (2017) · cites this paper as [211]
In the citing paper
“This study confirmed the low sensitivity and specificity of 1-mg DST when the high or low cutoff, respectively, is used and the low accuracy of the reduced ACTH and increased UFC level, when used as single criterion (59).”
From Diagnosis and Treatment of Subclinical Hypercortisolism (2011) · cites this paper as [59]
In the citing paper
“However, to date, the DST-UFC-ACTH combination criterion seems the best compromise to diagnose SH because it has been validated on a clinical basis (32,59,60).”
From Diagnosis and Treatment of Subclinical Hypercortisolism (2011) · cites this paper as [59]
Citations
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Incidentally Discovered Adrenal Masses*
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Tauchmanovà, L., Rossi, R., Biondi, B., Pulcrano, M., Nuzzo, V., Palmieri, E.-A., Fazio, S., & Lombardi, G. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2001-011766 · Cited by 400
Reincke, M., Nieke, J., Krestin, G. P., Saeger, W., Allolio, B., & Winkelmann, W. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.3.1517373 · Cited by 346
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Hajduk, A., Miazgowski, T., & Widecka, K. (2011)
Papierska, L., Glinicki, P., Otto, M., & Kasperlik-Zaøuska, A. (2015)
Subclinical Cushing’s syndrome: lots of questions — little answers
Rybakov, S. I. (2021) · INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) · doi:10.22141/2224-0721.17.6.2021.243216
Pizzorno, L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-43044-9.00203-x
Is It Relevant to Screen Subclinical Cushing’s Syndrome in Patients With Type 2 Diabetes Mellitus?
Hadiji, M. J., Ksira, I., Haouat, E., Jamoussi, H. K., & Hachmi, L. B. S. (2017) · Journal of Endocrinology and Metabolism · doi:10.14740/jem454w
Trandafir, A.-I., Stanciu, M., Albu, S. E., Stoian, V. R., CIOFU, I., Persu, C., Nistor, C., & Carşote, M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12134244
Trandafir, A.-I., Stanciu, M., Valea, A., Sima, O.-C., Nistor, C., Iliescu, M. G., Ciobanu, I., Popa, F. L., & Carşote, M. (2024) · Balneo and PRM Research Journal · doi:10.12680/balneo.2024.692
Metadata
- Authors
- Morelli, V., Masserini, B., Salcuni, A. S., Eller‐Vainicher, C., Savoca, C., Viti, R., Coletti, F., Guglielmi, G., Battista, C., Iorio, L., Beck‐Peccoz, P., Ambrosi, B., Arosio, M., Scillitani, A., & Chiodini, I.
- Affiliations
- University of Milan (IT)
- Casa Sollievo della Sofferenza (IT)
- Corresponding author
- Chiodini, I.
- ORCID
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2010-07-21
- Volume
- 73
- Issue
- 2
- Pages
- 161-166
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2083751700
- Cited by
- 107
- References
- 31
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 10 · 2020: 3 · 2019: 3 · 2018: 12 · 2017: 6 · 2016: 9 · 2015: 12 · 2014: 5 · 2013: 4 · 2012: 14
- FWCI
- 8.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- subclinical hypercortisolism, adrenal incidentaloma, urinary free cortisol, ACTH, hypertension, type 2 diabetes, vertebral fractures, diagnostic criteria
- MeSH terms
- Adenoma, Adrenal Gland Neoplasms, Adrenocorticotropic Hormone, Aged, Cushing Syndrome, Dexamethasone, Female, Humans, Hydrocortisone, Male, Middle Aged, Pituitary-Adrenal Function Tests, Predictive Value of Tests, Retrospective Studies, Incidental Findings
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