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Cited by 107Adrenal Hormones and DisordersAdrenal and Paraganglionic TumorsHormonal Regulation and Hypertension

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Subclinical hypercortisolism: correlation between biochemical diagnostic criteria and clinical aspects

Morelli, V., Masserini, B., Salcuni, A. S., Eller‐Vainicher, C., Savoca, C., Viti, R., Coletti, F., Guglielmi, G., Battista, C., Iorio, L., Beck‐Peccoz, P., Ambrosi, B., Arosio, M., Scillitani, A., Chiodini, I.·2010·Clinical Endocrinology
DOI 10.1111/j.1365-2265.2010.03794.x
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Abstract

OBJECTIVE: Subclinical hypercortisolism (SH) has been associated with increased prevalence of hypertension, type 2 diabetes mellitus, dyslipidaemia, central obesity, osteoporosis and vertebral fractures. We aimed to investigate the accuracy of different SH diagnostic criteria in predicting the presence of complications. DESIGN: This was a retrospective study. PATIENTS: We evaluated data from 231 patients (120 women and 111 men) affected with adrenal incidentalomas (AI). MEASUREMENTS: We studied the accuracy of different SH diagnostic criteria (cortisol after 1 mg overnight dexamethasone suppression test - 1mg-DST - at different cut-off such as 49.7, 82.8, 137.9 nmol/l, elevated urinary free cortisol, reduced adrenal corticotroph hormone (ACTH) levels alone or various combination of these parameters) in predicting the concomitant presence of the following three complications: hypertension, type 2 diabetes and vertebral fractures. RESULTS: The criterion characterized by the presence of two of 1mg-DST >82.8 nmol/l, elevated UFC and reduced ACTH struck the best balance between sensitivity and specificity, reaching a good accuracy in predicting the cluster of complications (61.9%; 77.1% and 75.8%, respectively). The presence of this cluster was associated with this criterion (OR 4.75, 95%CI 1.8-12.7, P = 0.002) regardless of gonadal status, body mass index (BMI) and age. CONCLUSIONS: The SH criterion characterized by the presence of two of 1mg-DST >82.8 nmol/l, elevated UFC and reduced ACTH seems the best in predicting the presence of chronic manifestations of subtle cortisol excess.

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Crossref · 10.1111/j.1365-2265.2010.03794.x

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Research works printed but not linked: 3

  1. Mantero F., 2000, A survey on adrenal incidentaloma in Italy. Study Group on Adrenal Tumors of the Italian Society of Endocrinology, The Journal of clinical endocrinology and metabolism, 85, 637
  2. 10.1210/jc.75.3.826 · DOI
  3. 10.1210/jc.85.4.1440 · DOI

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Metadata

Authors
Morelli, V., Masserini, B., Salcuni, A. S., Eller‐Vainicher, C., Savoca, C., Viti, R., Coletti, F., Guglielmi, G., Battista, C., Iorio, L., Beck‐Peccoz, P., Ambrosi, B., Arosio, M., Scillitani, A., & Chiodini, I.
Affiliations
  • University of Milan (IT)
  • Casa Sollievo della Sofferenza (IT)
Corresponding author
Chiodini, I.
ORCID
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2010-07-21
Volume
73
Issue
2
Pages
161-166
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/j.1365-2265.2010.03794.x
OpenAlex
W2083751700
Cited by
107
References
31
Citations by year
2025: 1 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 10 · 2020: 3 · 2019: 3 · 2018: 12 · 2017: 6 · 2016: 9 · 2015: 12 · 2014: 5 · 2013: 4 · 2012: 14
FWCI
8.45
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords
subclinical hypercortisolism, adrenal incidentaloma, urinary free cortisol, ACTH, hypertension, type 2 diabetes, vertebral fractures, diagnostic criteria
MeSH terms
Adenoma, Adrenal Gland Neoplasms, Adrenocorticotropic Hormone, Aged, Cushing Syndrome, Dexamethasone, Female, Humans, Hydrocortisone, Male, Middle Aged, Pituitary-Adrenal Function Tests, Predictive Value of Tests, Retrospective Studies, Incidental Findings

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