The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Thyroid function and the risk of coronary heart disease: 12‐year follow‐up of the HUNT S tudy in Norway
Abstract
OBJECTIVE: In a mortality follow-up of the HUNT Study, serum TSH within the reference range was positively associated with the risk of coronary death in women. We now aimed to confirm the association of high serum TSH with the risk of coronary heart disease, using hospital-based diagnoses of myocardial infarction. DESIGN: Prospective population-based study with linkage to hospital information on myocardial infarction and to the national Cause of Death Registry. PARTICIPANTS: A total of 26, 707 people without previously known thyroid or cardiovascular disease or diabetes at baseline. MEASUREMENTS: Hazard ratios (HR) of coronary death and HRs of hospitalization with a first-time acute myocardial infarction, by baseline thyroid function. RESULTS: During 12, years of follow-up, 960 (3·6%) participants had been hospitalized with first-time myocardial infarction and 558 (2·1%) had died from coronary heart disease. High TSH within the reference range was associated with increased risk of coronary death in women (P(trend) 0·005), but not in men. The risk of coronary death was also increased among women with subclinical hypothyroidism or subclinical hyperthyroidism, compared to women with TSH of 0·50-1·4 mU/l. However, thyroid function was not associated with the risk of being hospitalized with myocardial infarction. CONCLUSIONS: High serum TSH was associated with increased mortality from coronary heart disease in women, but we found no association of thyroid function with the risk of being hospitalized with myocardial infarction. Thus, the morbidity finding does not confirm the suggestion that low thyroid function within the clinically normal range is associated with increased risk of coronary heart disease.
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“A recent large study of 26,707 people followed for 12 years reported increased cardiovascular mortality with SH (389).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [389]
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The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey
Vanderpump, M. P. J., Tunbrldge, W. M. G., French, J. M., Appleton, D., Bates, D., Clark, F., Evans, J. G., Hasan, D. M., Rodgers, H., Tunbridge, F., et al. (1995) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1995.tb01894.x · Cited by 2,432
The Clinical Significance of Subclinical Thyroid Dysfunction
Biondi, B., & Cooper, D. S. (2008) · Endocrine Reviews · doi:10.1210/er.2006-0043 · Cited by 1,418
Low Serum Thyrotropin Concentrations as a Risk Factor for Atrial Fibrillation in Older Persons
Sawin, C. T., Geller, A., Wolf, P. A., Belanger, A. J., Baker, E., Bacharach, P., Wilson, P., Benjamin, E. J., & D'Agostino, R. B. (1994) · New England Journal of Medicine · doi:10.1056/nejm199411103311901 · Cited by 1,259
Subclinical Hypothyroidism and the Risk of Coronary Heart Disease and Mortality
Rodondi, N., den Elzen, W. P. J., Bauer, D. C., Cappola, A. R., Razvi, S., Walsh, J. P., Åsvold, B. O., Iervasi, G., Imaizumi, M., Collet, T.-H., et al. (2010) · JAMA · doi:10.1001/jama.2010.1361 · Cited by 1,216
Self-citationThyroid Status, Cardiovascular Risk, and Mortality in Older Adults
Cappola, A. R., Fried, L. P., Arnold, A. M., Danese, M. D., Kuller, L. H., Burke, G. L., Tracy, R. P., & Ladenson, P. W. (2006) · JAMA · doi:10.1001/jama.295.9.1033 · Cited by 862
Parle, J. V., Maisonneuve, P., Sheppard, M. C., Boyle, P., & Franklyn, J. A. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06067-6 · Cited by 669
Hypothyroidism and Atherosclerosis
Cappola, A. R., & Ladenson, P. W. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030398 · Cited by 640
Subclinical hyperthyroidism and the risk of coronary heart disease and mortality
Collet, T.-H., Gussekloo, J., Bauer, D. C., den Elzen, W. P. J., Cappola, A. R., Balmer, P., Iervasi, G., Åsvold, B. O., Sgarbi, J. A., Völzke, H., et al. (2012) · Archives of Internal Medicine · doi:10.1001/archinternmed.2012.402 · Cited by 572
Self-citationSubclinical thyroid dysfunction as a risk factor for cardiovascular disease
Walsh, J. P., Bremner, A. P., Bulsara, M. K., O’Leary, P., Leedman, P. J., Feddema, P., & Michelangeli, V. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.21.2467 · Cited by 536
The Nord-Trøndelag Health Study 1995-97 (HUNT 2): Objectives, contents, methods and participation
Holmen, J., Midthjell, K., Krüger, Ø., Langhammer, A., Holmen, T. L., Bratberg, G. H., Vatten, L., & Lund‐Larsen, P. G. (2003) · Cited by 526
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Li, Y., Zhai, W., Guo, Z., Ren, M., Shuhaiber, J. H., Raja, S. G., Lampridis, S., & Han, J. (2024) · Journal of Thoracic Disease · doi:10.21037/jtd-24-655
Li, M.-F., KE, J., Li, S., Wang, J.-W., Zhu, Z.-H., & Li, J.-B. (2021) · Figshare · doi:10.6084/m9.figshare.17126144
Stedman, M., Taylor, P. N., Halsall, I., Halsall, D. J., Okosieme, B., Bahl, S., Veluchamy, S., Premawardhana, L. D. K. E., Fryer, A. A., Dayan, C. M., et al. (2026) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.70214
Liang, N., Ma, H., Wang, X., Meng, J., Ru, Z., Lv, N., Li, K., & Qiao, H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1803188
Catană, M.-G., & Valeanu, M. (2026) · Neurology International · doi:10.3390/neurolint18100196
Metadata
- Authors
- Åsvold, B. O., Bjøro, T., Platou, C., & Vatten, L. J.
- Affiliations
- Norwegian University of Science and Technology (NO)
- Oslo University Hospital (NO)
- Levanger Hospital (NO)
- Corresponding author
- Åsvold, Bjørn O.
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2012-11-09
- Volume
- 77
- Issue
- 6
- Pages
- 911-917
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2071776226
- Cited by
- 107
- References
- 29
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 7 · 2022: 7 · 2021: 11 · 2020: 12 · 2019: 5 · 2018: 6 · 2017: 9 · 2016: 9 · 2015: 13 · 2014: 6 · 2013: 13 · 2012: 1
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- thyroid-stimulating hormone, subclinical hypothyroidism, subclinical hyperthyroidism, coronary artery disease, myocardial infarction, coronary heart disease mortality, sex differences, thyroid function, HUNT study
- MeSH terms
- Aged, Coronary Disease, Female, Heart Failure, Hospitalization, Humans, Hypothyroidism, Male, Middle Aged, Myocardial Infarction, Norway, Reference Values, Risk Factors, Thyrotropin, Thyroxine, Triiodothyronine
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