The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Thyroid function and the risk of coronary heart disease: 12‐year follow‐up of the HUNT S tudy in Norway
Abstract
OBJECTIVE: In a mortality follow-up of the HUNT Study, serum TSH within the reference range was positively associated with the risk of coronary death in women. We now aimed to confirm the association of high serum TSH with the risk of coronary heart disease, using hospital-based diagnoses of myocardial infarction. DESIGN: Prospective population-based study with linkage to hospital information on myocardial infarction and to the national Cause of Death Registry. PARTICIPANTS: A total of 26, 707 people without previously known thyroid or cardiovascular disease or diabetes at baseline. MEASUREMENTS: Hazard ratios (HR) of coronary death and HRs of hospitalization with a first-time acute myocardial infarction, by baseline thyroid function. RESULTS: During 12, years of follow-up, 960 (3·6%) participants had been hospitalized with first-time myocardial infarction and 558 (2·1%) had died from coronary heart disease. High TSH within the reference range was associated with increased risk of coronary death in women (P(trend) 0·005), but not in men. The risk of coronary death was also increased among women with subclinical hypothyroidism or subclinical hyperthyroidism, compared to women with TSH of 0·50-1·4 mU/l. However, thyroid function was not associated with the risk of being hospitalized with myocardial infarction. CONCLUSIONS: High serum TSH was associated with increased mortality from coronary heart disease in women, but we found no association of thyroid function with the risk of being hospitalized with myocardial infarction. Thus, the morbidity finding does not confirm the suggestion that low thyroid function within the clinically normal range is associated with increased risk of coronary heart disease.
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“A recent large study of 26,707 people followed for 12 years reported increased cardiovascular mortality with SH (389).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [389]
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“A recent large study of 26,707 people followed for 12 years reported increased cardiovascular mortality with SH (389).”
BackgroundHormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline
Fleseriu, M., Hashim, I. A., Karavitaki, N., Melmed, S., Murad, M. H., Salvatori, R., & Samuels, M. H. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2118 · Cited by 945
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A Review of the Clinical Consequences of Variation in Thyroid Function Within the Reference Range
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Thyroid Function in the Euthyroid Range and Adverse Outcomes in Older Adults
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Metadata
- Authors
- Åsvold, B. O., Bjøro, T., Platou, C., & Vatten, L. J.
- Affiliations
- Norwegian University of Science and Technology (NO)
- Oslo University Hospital (NO)
- Levanger Hospital (NO)
- Corresponding author
- Åsvold, Bjørn O.
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2012-11-09
- Volume
- 77
- Issue
- 6
- Pages
- 911-917
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2071776226
- Cited by
- 107
- References
- 29
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 7 · 2022: 7 · 2021: 11 · 2020: 12 · 2019: 5 · 2018: 6 · 2017: 9 · 2016: 9 · 2015: 13 · 2014: 6 · 2013: 13 · 2012: 1
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- thyroid-stimulating hormone, subclinical hypothyroidism, subclinical hyperthyroidism, coronary artery disease, myocardial infarction, coronary heart disease mortality, sex differences, thyroid function, HUNT study
- MeSH terms
- Aged, Coronary Disease, Female, Heart Failure, Hospitalization, Humans, Hypothyroidism, Male, Middle Aged, Myocardial Infarction, Norway, Reference Values, Risk Factors, Thyrotropin, Thyroxine, Triiodothyronine
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