The proinflammatory cytokine-induced IRG1 protein associates with mitochondria

Cluster analysis and display of genome-wide expression patterns

Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14863 · Cited by 12,617 · see citing works

In silico prediction of protein-protein interactions in human macrophages

Souiai, O., Guerfali, F. Z., Miled, S. B., Brun, C., & Benkahla, A. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-157 · Cited by 10,785 · see citing works

Significance analysis of microarrays applied to the ionizing radiation response

Tusher, V. G., Tibshirani, R., & Chu, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091062498 · Cited by 10,568 · see citing works

Interferon-γ: an overview of signals, mechanisms and functions

Schroder, K., Hertzog, P. J., Ravasi, T., & Hume, D. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603252 · Cited by 4,120 · see citing works

Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

Seth, R. B., Sun, L., Ea, C.-K., & Chen, Z. J. (2005) · Cell · doi:10.1016/j.cell.2005.08.012 · Cited by 3,329 · see citing works

Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection.

Li, C., & Wong, W. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.31 · Cited by 3,133 · see citing works

CELLULAR RESPONSES TO INTERFERON-γ

Boehm, U., Klamp, T., Groot, M., & Howard, J. C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.749 · Cited by 2,890 · see citing works

An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.

Flynn, J. L., Chan, J., Triebold, K. J., Dalton, D. K., Stewart, T. A., & Bloom, B. R. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.6.2249 · Cited by 2,468 · see citing works

Mitochondria: More Than Just a Powerhouse

McBride, H. M., Neuspiel, M., & Wasiak, S. (2006) · Current Biology · doi:10.1016/j.cub.2006.06.054 · Cited by 1,985 · see citing works

VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling

Xu, L., Wang, Y., Han, K.-J., Li, L., Zhai, Z., & Shu, H. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.08.014 · Cited by 1,849 · see citing works

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

Dalton, D. K., Pitts-Meek, S., Keshav, S., Figari, I. S., Bradley, A., & Stewart, T. A. (1993) · Science · doi:10.1126/science.8456300 · Cited by 1,733 · see citing works

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

Pfeffer, K., Matsuyama, T., Kündig, T. M., Wakeham, A., Kishihara, K., Shahinian, A., Wiegmann, K., Ohashi, P. S., Krönke, M., & Mak, T. W. (1993) · Cell · doi:10.1016/0092-8674(93)90134-c · Cited by 1,677 · see citing works

Immune Response in Mice that Lack the Interferon-γ Receptor

Huang, S., Hendriks, W. J. A. J., Althage, A., Hemmi, S., Bluethmann, H., Kamijo, R., Vilček, J., Zinkernagel, R. M., & Aguet, M. (1993) · Science · doi:10.1126/science.8456301 · Cited by 1,551 · see citing works

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

MacMicking, J. D., Nathan, C., Hom, G. J., Chartrain, N. A., Fletcher, D. S., Trumbauer, M. E., Stevens, K. A., Xie, Q. W., Sokol, K. A., Hutchinson, N. I., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90085-3 · Cited by 1,445 · see citing works

Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

Rothe, J., Lesslauer, W., Loetscher, H., Lang, Y., Koebel, P., Köntgen, F., Althage, A., Zinkernagel, R. M., Steinmetz, M., & Bluethmann, H. (1993) · Nature · doi:10.1038/364798a0 · Cited by 1,246 · see citing works

FatiGO: a web tool for finding significant associations of Gene Ontology terms with groups of genes

Al‐Shahrour, F., Díaz‐Uriarte, R., & Dopazo, J. (2004) · Bioinformatics · doi:10.1093/bioinformatics/btg455 · Cited by 1,118 · see citing works

The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games

Hehlgans, T., & Pfeffer, K. (2005) · Immunology · doi:10.1111/j.1365-2567.2005.02143.x · Cited by 1,049 · see citing works

Requirement of endogenous interferon-gamma production for resolution of Listeria monocytogenes infection.

Buchmeier, N. A., & Schreiber, R. D. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.21.7404 · Cited by 544 · see citing works

Stereotyped and specific gene expression programs in human innate immune responses to bacteria

Boldrick, J. C., Alizadeh, A. A., Diehn, M., Dudoit, S., Liu, C. L., Belcher, C. E., Botstein, D., Staudt, L. M., Brown, P. O., & Relman, D. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231625398 · Cited by 390 · see citing works

Synergism between tumor necrosis factor‐α and interferon‐γ on macrophage activation for the killing of intracellular Trypanosoma cruzi through a nitric oxide‐dependent mechanism

Muñoz‐Fernández, M. Á., Fernández, M. A., & Fresno, M. (1992) · European Journal of Immunology · doi:10.1002/eji.1830220203 · Cited by 288 · see citing works

Two families of GTPases dominate the complex cellular response to IFN-gamma.

Boehm, U., Guethlein, L. A., Klamp, T., Ozbek, K., Schaub, A., Fütterer, A., Pfeffer, K., & Howard, J. C. (1998) · PubMed · Cited by 224 · see citing works

Extensive Characterization of IFN-Induced GTPases mGBP1 to mGBP10 Involved in Host Defense

Degrandi, D., Konermann, C., Beuter-Gunia, C., Kresse, A., Wuerthner, J., Kurig, S., Beer, S., & Pfeffer, K. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.11.7729 · Cited by 209 · see citing works

Two Families of GTPases Dominate the Complex Cellular Response to IFN-γ

Boehm, U., Guethlein, L. A., Klamp, T., Ozbek, K., Schaub, A., Fütterer, A., Pfeffer, K., & Howard, J. C. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.12.6715 · Cited by 208 · see citing works

Essential Role of Gamma Interferon in Survival of Colon Ascendens Stent Peritonitis, a Novel Murine Model of Abdominal Sepsis

Zantl, N., Uebe, A., Neumann, B., Wagner, H., Siewert, J., Holzmann, B., Heidecke, C.-D., & Pfeffer, K. (1998) · Infection and Immunity · doi:10.1128/iai.66.5.2300-2309.1998 · Cited by 206 · see citing works

Synergistic action of pro-inflammatory agents: cellular and molecular aspects

Paludan, S. R. (2000) · Journal of Leukocyte Biology · doi:10.1002/jlb.67.1.18 · Cited by 177 · see citing works

Cloning and analysis of gene regulation of a novel LPS-inducible cDNA

Lee, C. L., Jenkins, N., Gilbert, D., Copeland, N., & O'Brien, W. (1995) · Immunogenetics · doi:10.1007/bf00172150 · Cited by 165 · see citing works

Crucial Role of Interferon Consensus Sequence Binding Protein, but neither of Interferon Regulatory Factor 1 nor of Nitric Oxide Synthesis for Protection Against Murine Listeriosis

Fehr, T., Schoedon, G., Odermatt, B., Holtschke, T., Schneemann, M., Bachmann, M. F., Mak, T. W., Horak, I., & Zinkernagel, R. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.5.921 · Cited by 162 · see citing works

The Interferon-Inducible GTPases

Martens, S., & Howard, J. C. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104619 · Cited by 162 · see citing works

MyD88 Primes Macrophages for Full-Scale Activation by Interferon-γ yet Mediates Few Responses to Mycobacterium tuberculosis

Shi, S., Nathan, C., Schnappinger, D., Drenkow, J., Fuortes, M., Block, E. F., Ding, A. H., Gingeras, T., Schoolnik, G. K., Akira, S., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030603 · Cited by 146 · see citing works

Macrophage nutriprive antimicrobial mechanisms

Appelberg, R. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0206079 · Cited by 145 · see citing works

Interferon γ and lymphotoxin or tumor necrosis factor act synergistically to induce macrophage killing of tumor cells and schistosomula of schistosoma mansoni

Esparza, I., Männel, D. N., Ruppel, A., Falk, W., & Krammer, P. (1987) · The Journal of Experimental Medicine · doi:10.1084/jem.166.2.589 · Cited by 137 · see citing works

The CD40/CD40 Ligand Interaction Is Required for Resistance to Toxoplasmic Encephalitis

Reichmann, G., Walker, W., Villegas, E. N., Craig, L. E., Cai, G., Alexander, J. K., & Hunter, C. A. (2000) · Infection and Immunity · doi:10.1128/iai.68.3.1312-1318.2000 · Cited by 130 · see citing works

Listeriosis in p47phox−/− and TRp55−/− Mice: Protection Despite Absence of ROI and Susceptibility Despite Presence of RNI

Endres, R., Luz, A., Schulze, H., Neubauer, H. J., Fütterer, A., Holland, S. M., Wagner, H., & Pfeffer, K. (1997) · Immunity · doi:10.1016/s1074-7613(00)80363-5 · Cited by 124 · see citing works

Heterogeneity of Hematopoietic Cells Immortalized by v-myc/v-raf Recombinant Retrovirus Infection of Bone Marrow or Fetal Liver

Cox, G. W., Mathieson, B. J., Gandino, L., Blasi, E., Radzioch, D., & Varesio, L. (1989) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/81.19.1492 · Cited by 123 · see citing works

High sensitivity of transgenic mice expressing soluble TNFR1 fusion protein to mycobacterial infections: Synergistic action of TNF and IFN‐γ in the differentiation of protective granulomas

Garcia, I., Miyazaki, Y., Marchal, G., Lesslauer, W., & VASSALLI, P. (1997) · European Journal of Immunology · doi:10.1002/eji.1830271215 · Cited by 106 · see citing works

TNF-alpha and IFN-gamma stimulate a macrophage precursor cell line to kill Listeria monocytogenes in a nitric oxide-independent manner.

Leenen, P. J. M., Canono, B. P., Drevets, D. A., et al. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.11.5141 · Cited by 83 · see citing works

Immune-Responsive Gene 1 Is a Novel Target of Progesterone Receptor and Plays a Critical Role during Implantation in the Mouse

Cheon, Y.-P., Xu, X., Bagchi, M. K., & Bagchi, I. C. (2003) · Endocrinology · doi:10.1210/en.2003-0585 · Cited by 76 · see citing works

Mycobacterium paratuberculosis, Mycobacterium smegmatis, and lipopolysaccharide induce different transcriptional and post-transcriptional regulation of the IRG1 gene in murine macrophages

Basler, T., Jeckstadt, S., Valentin‐Weigand, P., & Goethe, R. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0905520 · Cited by 65 · see citing works

Cutting Edge: A Novel Nonoxidative Phagosomal Mechanism Exerted by Cathepsin-D Controls <i>Listeria monocytogenes</i> Intracellular Growth

del Cerro-Vadillo, E., Madrazo-Toca, F., Carrasco-Marín, E., Fernandez-Prieto, L., Beck, C., Leyva-Cobián, F., Saftig, P., & Alvarez-Dominguez, C. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.3.1321 · Cited by 53 · see citing works

Progesterone Regulation of the Mammalian Ortholog of Methylcitrate Dehydratase (Immune Response Gene 1) in the Uterine Epithelium during Implantation through the Protein Kinase C Pathway

Chen, B., Zhang, D., & Pollard, J. W. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0207 · Cited by 42 · see citing works

Tumour necrosis factor-alpha (TNF-α) in the host resistance to mycobacteria of distinct virulence

Appelberg, R., Sarmento, A., & Castro, A. G. (1995) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1995.tb08356.x · Cited by 35 · see citing works

Inhibition of group B streptococcal growth by IFNγ-activated human glioblastoma cells

MacKenzie, C. R., Willberg, C. B., & Däubener, W. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00138-6 · Cited by 20 · see citing works

Inhibition of the multiplication ofListeria monocytogenesin a murine hepatocyte cell line (ATCC TIB73) by IFN-γ and TNF-α

Haponsaph, R., & Czuprynski, C. J. (1996) · Microbial Pathogenesis · doi:10.1006/mpat.1996.0027 · Cited by 9 · see citing works

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

Michelucci, A., Cordes, T., Ghelfi, J., Pailot, A., Reiling, N., Goldmann, O., Binz, T., Wegner, A., Tallam, A., Rausell, A., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218599110 · Cited by 1,191 · see citing works

Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

Cordes, T., Wallace, M., Michelucci, A., Divakaruni, A. S., Sapcariu, S. C., Sousa, C., Koseki, H., Cabrales, P., Murphy, A. N., Hiller, K., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.685792 · Cited by 526 · see citing works

<i>Irg1</i> expression in myeloid cells prevents immunopathology during <i>M. tuberculosis</i> infection

Nair, S., Huynh, J. P., Lampropoulou, V., Loginicheva, E., Esaulova, E., Gounder, A. P., Boon, A. C. M., Schwarzkopf, E. A., Bradstreet, T. R., Edelson, B. T., et al. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20180118 · Cited by 280 · see citing works

Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors

Weiss, J. M., Davies, L. C., Karwan, M., Ileva, L., Ozaki, M. K., Cheng, R. Y. S., Ridnour, L. A., Annunziata, C. M., Wink, D. A., & McVicar, D. W. (2018) · Journal of Clinical Investigation · doi:10.1172/jci99169 · Cited by 267 · see citing works

Immunoresponsive Gene 1 Augments Bactericidal Activity of Macrophage-Lineage Cells by Regulating β-Oxidation-Dependent Mitochondrial ROS Production

Hall, C. J., Boyle, R. H., Astin, J. W., Flores, M. V., Oehlers, S. H., Sanderson, L. E., Ellett, F., Lieschke, G. J., Crosier, K. E., & Crosier, P. S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.06.018 · Cited by 266 · see citing works

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid

Naujoks, J., Tabeling, C., Dill, B. D., Hoffmann, C., Brown, A. S., Kunze, M., Kempa, S., Peter, A., Mollenkopf, H.-J., Dorhoi, A., et al. (2016) · PLOS Pathogens · doi:10.1371/journal.ppat.1005408 · Cited by 261 · see citing works

Pro-inflammatory Macrophages Sustain Pyruvate Oxidation through Pyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression

Meiser, J., Krämer, L., Sapcariu, S. C., Battello, N., Ghelfi, J., D'Herouel, A. F., Skupin, A., & Hiller, K. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.676817 · Cited by 243 · see citing works

Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive-stranded RNA viruses

Cho, H., Proll, S. C., Szretter, K. J., Katze, M. G., Gale, M., & Diamond, M. S. (2013) · Nature Medicine · doi:10.1038/nm.3108 · Cited by 228 · see citing works

Immune Responsive Gene 1 (IRG1) Promotes Endotoxin Tolerance by Increasing A20 Expression in Macrophages through Reactive Oxygen Species

Li, Y., Zhang, P., Wang, C., Han, C., Meng, J., Liu, X., Xu, S., Li, N., Wang, Q., Shi, X., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.454538 · Cited by 177 · see citing works

Abolition of mitochondrial substrate‐level phosphorylation by itaconic acid produced by LPS‐induced <i>Irg1</i> expression in cells of murine macrophage lineage

Németh, B., Doczi, J., Csete, D., Kacso, G., Ravasz, D., Adams, D., Kiss, G., Nagy, A. M., Horvath, G., Tretter, L., et al. (2016) · The FASEB Journal · doi:10.1096/fj.15-279398 · Cited by 136 · see citing works

Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense

Luan, H. H., & Medzhitov, R. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.08.013 · Cited by 130 · see citing works

MicroRNA-345-3p is a potential biomarker and ameliorates rheumatoid arthritis by reducing the release of proinflammatory cytokines

Ma, J., Zhao, W., Pei, X., et al. (2023) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-023-03797-3 · Cited by 3 · see citing works

Dihydrocapsaicin suppresses proinflammatory cytokines expression by enhancing nuclear factor IA in a NF-κB-dependent manner

Zhao, J., Hu, Y., Huang, C., et al. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.06.002 · Cited by 21 · see citing works

Effects of Proinflammatory Cytokines in the Heart

Zhang, C. (2004) · Life Science Research

Induction of inducible nitric oxide synthase and proinflammatory cytokines expression by o,p′-DDT in macrophages

Kim, J. (2004) · Toxicology Letters · doi:10.1016/j.toxlet.2003.12.001 · Cited by 45 · see citing works

Proinflammatory Cytokines Mediate GPCR Dysfunction

Mohan, M. L., Vasudevan, N. T., & Prasad, S. V. N. (2017) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000456 · Cited by 21 · see citing works