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Cited by 160Effects and risks of endocrine disrupting chemicalsHypothalamic control of reproductive hormonesSexual Differentiation and Disorders

High urinary phthalate concentration associated with delayed pubarche in girls

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Frederiksen, H., Sørensen, K., Mouritsen, A., Aksglaede, L., Hagen, C. P., Petersen, J. H., Skakkebaek, N. E., Andersson, A.‐M. +1 more·2012·International Journal of Andrology
DOI 10.1111/j.1365-2605.2012.01260.x
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Abstract

Phthalates are a group of chemicals present in numerous consumer products. They have anti-androgenic properties in experimental studies and are suspected to be involved in human male reproductive health problems. A few studies have shown associations between phthalate exposure and changes in pubertal timing among girls, although controversies exist. We determined the concentration of 12 phthalate metabolites in first morning urine samples from 725 healthy Danish girls (aged 5.6-19.1 years) in relation to age, pubertal development (breast and pubic hair stage) and reproductive hormone levels (luteinizing hormone, oestradiol and testosterone). Furthermore, urinary phthalates were determined in 25 girls with precocious puberty (PP). In general, the youngest girls with less advanced pubertal development had the highest first morning urinary concentration of the monobutyl phthalate isoforms (∑MBP((i+n))), monobenzyl phthalate (MBzP), metabolites of di-(2-ethylhexyl) phthalate (∑DEHPm) and of di-iso-nonyl phthalate (∑DINPm). After stratification of the urinary phthalate excretion into quartiles, we found that the age at pubarche was increasing with increasing phthalate metabolite quartiles (except for MEP). This trend was statistically significant when all phthalate metabolites (except MEP) were summarized and expressed as quartiles. No association between phthalates and breast development was observed. In addition, there were no differences in urinary phthalate metabolite levels b…

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  • Urinary MEP and MBP and the metabolites of DEHP and DiNP are associated with anomalies in pubertal development in girls.

    “Urinary MEP and MBP and the metabolites of DEHP and DiNP are associated with anomalies in pubertal development in girls [205].”

    From A Review of Biomonitoring of Phthalate Exposures (2019) · cites this paper as [205]

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Authors
Frederiksen, H., Sørensen, K., Mouritsen, A., Aksglaede, L., Hagen, C. P., Petersen, J. H., Skakkebaek, N. E., Andersson, A. ‐., & Juul, A.
Affiliations
Copenhagen University Hospital (DK)
Corresponding author
  • Frederiksen, H.
  • Hagen, C. P.
ORCID
Venue
International Journal of Andrology
Publisher
Wiley
Published
2012-03-19
Volume
35
Issue
3
Pages
216-226
ISSN
  • 0105-6263 (ISSN-L)
  • 1365-2605
DOI
10.1111/j.1365-2605.2012.01260.x
OpenAlex
W2146539655
Cited by
160
References
6
Citations by year
2026: 7 · 2025: 13 · 2024: 8 · 2023: 7 · 2022: 16 · 2021: 12 · 2020: 10 · 2019: 10 · 2018: 8 · 2017: 8 · 2016: 10 · 2015: 12 · 2014: 19 · 2013: 15 · 2012: 5
FWCI
11.29
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Andrology (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
  • Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords
phthalates, urinary phthalate metabolites, pubertal timing, precocious puberty, antiandrogenic effects, mono-n-butyl phthalate, monobenzyl phthalate, DEHP, reproductive hormones, breast development, girls
MeSH terms
Adolescent, Breast, Child, Child, Preschool, Denmark, Environmental Pollutants, Female, Hair, Humans, Phthalic Acids, Puberty, Puberty, Precocious, White People, Young Adult

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