Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118
Open accessAbstract
The mechanisms by which probiotic strains enhance the health of the host remain largely uncharacterized. Here we demonstrate that Lactobacillus salivarius UCC118, a recently sequenced and genetically tractable probiotic strain of human origin, produces a bacteriocin in vivo that can significantly protect mice against infection with the invasive foodborne pathogen Listeria monocytogenes. A stable mutant of Lb. salivarius UCC118 that is unable to produce the Abp118 bacteriocin also failed to protect mice against infection with two strains of L. monocytogenes, EGDe and LO28, confirming that bacteriocin production is the primary mediator of protection against this organism. Furthermore, Lb. salivarius UCC118 did not offer any protection when mice were infected with a strain of L. monocytogenes expressing the cognate Abp118 immunity protein AbpIM, confirming that the antimicrobial effect is a result of direct antagonism between Lb. salivarius and the pathogen, mediated by the bacteriocin Abp118.
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The inhibitory activities of the bacterial isolates might be effective as a result of the production of antimicrobial substances such as lactic acid, hydrogen peroxide and bacteriocins.
“The inhibitory activities of bacterial isolates might be effective as a result of the production of antimicrobial substances such as lactic acid, hydrogen peroxide and bacteriocins [43,44].”
From Bioprophylactic potential of novel human colostrum probiotics via apoptotic induction of colon cancer cells and cell immune activation (2022) · cites this paper as [43]
The Results section reports that bacteriocin-producing Lactobacillus salivarius UCC118 inhibited Listeria and reduced infection in mice, supporting bacteriocins as one possible mechanism. The passages do not support lactic acid or hydrogen peroxide as explanations for the isolates’ inhibitory activity; a search for those terms found no such finding. (LLM, conf=0.87)
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- Authors
- Corr, S. C., Li, Y., Riedel, C. U., O'Toole, P. W., Hill, C., & Gahan, C. G. M.
- Affiliations
- University College Cork (IE)
- *Alimentary Pharmabiotic Centre and Department of Microbiology and
- Corresponding author
- Hill, Colin
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2007-05
- Volume
- 104
- Issue
- 18
- Pages
- 7617-7621
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1863472
- OpenAlex
- W1987838634
- Cited by
- 853
- References
- 24
- Citations by year
- 2026: 21 · 2025: 44 · 2024: 29 · 2023: 32 · 2022: 41 · 2021: 54 · 2020: 53 · 2019: 43 · 2018: 45 · 2017: 57 · 2016: 42 · 2015: 47 · 2014: 59 · 2013: 44 · 2012: 61
- FWCI
- 66.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Science Foundation Ireland
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Physical Sciences › Environmental Science › Ecology › Bacteriophages and microbial interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Listeria monocytogenes in Food Safety
- Keywords
- bacteriocin production, Listeria monocytogenes, antimicrobial antagonism, probiotic mechanisms of action
- MeSH terms
- Animals, Anti-Infective Agents, Bacteriocins, Lactobacillus, Liver Diseases, Mutation, Spleen, Gram-Positive Bacterial Infections, Mice
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