Hyperthyroidism and venous thrombosis: a casual or causal association? A systematic literature review
Open accessAbstract
A kaleidoscope of coagulation disorders have been reported in patients with thyroid dysfunctions. Globally, these disorders involve both primary and secondary hemostasis and range from subclinical laboratory abnormalities to, more rarely, life-threatening hemorrhages or thrombotic events. While overt hypothyroidism appears to be associated with a bleeding tendency, hyperthyroidism emerged to have an increased risk of thrombotic events. In particular, a number of case reports have documented acute venous thrombosis complications in patients with overt hyperthyroidism, especially at cerebral sites. Nevertheless, further observational and intervention studies might be needed to provide a more definitive information on the clinical relevance of this association, along with the potential implication for prevention and treatment of coagulation-fibrinolytic abnormalities in patients with thyroid dysfunction.
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Published case reports suggest a tendency toward increased overall thrombosis in hyperthyroidism.
“review of published case reports in hyperthyroidism suggests a tendency toward increased overall thrombosis(61).”
From Thyroid Hormones and Cardiovascular Function and Diseases (2018) · cites this paper as [61]
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- Authors
- Franchini, M., Lippi, G., & Targher, G.
- Affiliations
- University of Parma (IT)
- University of Verona (IT)
- Corresponding author
- Franchini, Massimo
- Venue
- Clinical and Applied Thrombosis/Hemostasis
- Publisher
- SAGE Publications
- Published
- 2010-03-22
- Volume
- 17
- Issue
- 4
- Pages
- 387-392
- ISSN
- 1076-0296 (ISSN-L)
- 1938-2723
- OpenAlex
- W2165356623
- Cited by
- 71
- References
- 63
- Citations by year
- 2026: 2 · 2024: 5 · 2023: 3 · 2022: 8 · 2021: 5 · 2020: 4 · 2019: 2 · 2018: 10 · 2017: 6 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 5 · 2012: 7
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical and Applied Thrombosis/Hemostasis (publishedVersion)
- PubMed (publishedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Keywords
- hyperthyroidism, venous thrombosis, thyroid dysfunction, coagulopathy, cerebral venous thrombosis, bleeding tendency, hypothyroidism, fibrinolysis, thrombosis risk
- MeSH terms
- Adolescent, Adult, Aged, Female, Hemostasis, Humans, Hyperthyroidism, Hypothyroidism, Male, Middle Aged, Venous Thrombosis, Young Adult
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