Cited by 76Thyroid Disorders and TreatmentsVenous Thromboembolism Diagnosis and ManagementBlood Coagulation and Thrombosis Mechanisms

Hyperthyroidism and venous thrombosis: a casual or causal association? A systematic literature review

Open access
Franchini, Massimo, Lippi, Giuseppe, Targher, Giovanni·2011·Clinical and Applied Thrombosis/Hemostasis

Abstract

A kaleidoscope of coagulation disorders have been reported in patients with thyroid dysfunctions. Globally, these disorders involve both primary and secondary hemostasis and range from subclinical laboratory abnormalities to, more rarely, life-threatening hemorrhages or thrombotic events. While overt hypothyroidism appears to be associated with a bleeding tendency, hyperthyroidism emerged to have an increased risk of thrombotic events. In particular, a number of case reports have documented acute venous thrombosis complications in patients with overt hyperthyroidism, especially at cerebral sites. Nevertheless, further observational and intervention studies might be needed to provide a more definitive information on the clinical relevance of this association, along with the potential implication for prevention and treatment of coagulation-fibrinolytic abnormalities in patients with thyroid dysfunction.

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Crossref · 10.1177/1076029610364521

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63 of 63 references verified0 citation errors · 0 not checkable

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  • Published case reports suggest a tendency toward increased overall thrombosis in hyperthyroidism.

    “review of published case reports in hyperthyroidism suggests a tendency toward increased overall thrombosis(61).”

    From Thyroid Hormones and Cardiovascular Function and Diseases (2018) · cites this paper as [61]

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Authors
Franchini, M., Lippi, G., & Targher, G.
Affiliations
  • University of Parma (IT)
  • University of Verona (IT)
Corresponding author
Franchini, Massimo
Venue
Clinical and Applied Thrombosis/Hemostasis
Published
2010-03-22
Volume
17
Issue
4
Pages
387-392
ISSN
  • 1076-0296 (ISSN-L)
  • 1938-2723
OpenAlex
W2165356623
Cited by
71
References
63
Citations by year
2026: 2 · 2024: 5 · 2023: 3 · 2022: 8 · 2021: 5 · 2020: 4 · 2019: 2 · 2018: 10 · 2017: 6 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 5 · 2012: 7
FWCI
0.68
Type
journal article
Language
en
Open access
Locations
  • Clinical and Applied Thrombosis/Hemostasis (publishedVersion)
  • PubMed (publishedVersion)
  • INFM-OAR (INFN Catania) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
  • Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Keywords
hyperthyroidism, venous thrombosis, thyroid dysfunction, coagulopathy, cerebral venous thrombosis, bleeding tendency, hypothyroidism, fibrinolysis, thrombosis risk
MeSH terms
Adolescent, Adult, Aged, Female, Hemostasis, Humans, Hyperthyroidism, Hypothyroidism, Male, Middle Aged, Venous Thrombosis, Young Adult

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