The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Multiple cognitive deficits during the transition to Alzheimer's disease
Abstract
Abstract.: The literature on cognitive markers in preclinical AD is reviewed. The findings demonstrate that impairment in multiple cognitive domains is typically observed several years before clinical diagnosis. Measures of executive functioning, episodic memory and perceptual speed appear to be most effective at identifying at‐risk individuals. The fact that these cognitive domains are most implicated in normal cognitive aging suggests that the cognitive deficit observed preclinically is not qualitatively different from that observed in normal aging. The degree of cognitive impairment prior to the diagnosis of Alzheimer's disease (AD) appears to generalize relatively well across major study characteristics, including sample ascertainment procedures, age and cognitive status of participants, as well as time to diagnosis of dementia. In episodic memory, there is evidence that the size of the preclinical deficit increases with increasing cognitive demands. The global cognitive impairment observed is highly consistent with observations that multiple brain structures and functions are affected long before the diagnosis of AD. However, there is substantial overlap in the distribution of cognitive scores between those who will and those who will not be diagnosed with AD, hence limiting the clinical utility of cognitive markers for early identification of cases. Future research should consider combining cognitive indicators with other types of markers (i.e. social, somatic, genetic, brain‐based) in order to increase prediction accuracy.
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Cited by
Tabert, M. H., Manly, J. J., Liu, X., Pelton, G. H., Rosenblum, S., Jacobs, M., Zamora, D., Goodkind, M., Bell, K., Stern, Y., et al. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.916 · Cited by 600
Episodic memory in normal aging and Alzheimer disease: Insights from imaging and behavioral studies
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Serum Brain-Derived Neurotrophic Factor and the Risk for Dementia: The Framingham Heart Study
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The amyloid cascade hypothesis: an updated critical review
Kepp, K. P., Robakis, N. K., Høilund-Carlsen, P. F., Sensi, S. L., & Vissel, B. (2023) · Brain · doi:10.1093/brain/awad159 · Cited by 284
Metadata
- Authors
- Bäckman, L., Jones, S., Berger, A. ‐., Laukka, E. J., & Small, B. J.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2004-08-20
- Volume
- 256
- Issue
- 3
- Pages
- 195-204
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W2008699078
- Cited by
- 291
- References
- 103
- FWCI
- 7.91
- Type
- journal article
- Language
- en
- Open access
- closed
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