Serum lipid levels in relation to serum thyroid-stimulating hormone and the effect of thyroxine treatment on serum lipid levels in subjects with subclinical hypothyroidism: the Tromsø Study
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OBJECTIVE: To evaluate the relation between serum thyroid-stimulating hormone (TSH) and lipids. DESIGN: Cross-sectional epidemiological study, nested case-control study, and a placebo-controlled double-blind intervention study. METHODS: In the 5th Tromsø study serum TSH, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured. Subjects with subclinical hypothyroidism (SHT) and a matching control group were re-examined and apolipoprotein A1 (Apo A1) and apolipoprotein B (Apo B) were also measured. Subjects with SHT were included in an intervention study with thyroxine supplementation for 1 year. RESULTS: A total of 5143 subjects from the 5th Tromsø study were included. A significant and positive correlation between serum TSH levels and serum TC and LDL-C levels were found in both genders. However, in the females this did not reach statistical significance after adjusting for age and BMI. The serum LDL-C were significantly higher and the Apo A1 levels significantly lower in 84 SHT subjects compared with 145 controls, and in the SHT females the TC levels were also significantly elevated. In the intervention study (32 subjects given thyroxine and 32 subjects given placebo), we observed a significant reduction in the Apo B levels after thyroxine medication. In those that at the end of the study had serum TSH levels in the range 0.2-2.0 mIU L(-1), the serum TC and LDL-C levels were also significantly reduced. CONCLUSIONS: There is a positive association between serum TSH levels and TC and LDL-C levels. These lipid levels are reduced with thyroxine treatment in subjects with SHT.
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Two subsequent trials suggested that levothyroxine in subclinical hypothyroidism reduced low-density lipoprotein cholesterol by approximately 0.3 mmol/l (11.6 mg/dl).
“Two subsequent trials suggested that the reduction of LDL-C was approximately 0.3 mmol/l (11.6 mg/dl) (16,41).”
From Thyroid Hormones and Cardiovascular Function and Diseases (2018) · cites this paper as [41]
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Cites
The Colorado Thyroid Disease Prevalence Study
Canaris, G. J., Manowitz, N. R., Mayor, G., & Ridgway, E. C. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.4.526 · Cited by 2,824 · see citing works
Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study.
Kannel, W., Castelli, W., Gordon, T., & McNamara, P. M. (2020) · Annals of Internal Medicine · doi:10.7326/0003-4819-74-1-1 · Cited by 2,160 · see citing works
Nilssen, O., Førde, O. H., & Brenn, T. (1990) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115661 · Cited by 816 · see citing works
Knudsen, N., Laurberg, P., Rasmussen, L. B., Bülow, I., Perrild, H., Ovesen, L., & Jørgensen, T. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2225 · Cited by 753 · see citing works
Bjøro, T., Holmen, J., Krüger, Ø., Midthjell, K., Hunstad, K., Schreiner, T., Sandnes, L., & Brochmann, H. (2000) · European Journal of Endocrinology · doi:10.1530/eje.0.1430639 · Cited by 463 · see citing works
L-Thyroxine Therapy in Subclinical Hypothyroidism: A Double-Blind, Placebo-Controlled Trial
COOPER, D. S., HALPERN, R., WOOD, L. C., LEVIN, A. A., & RIDGWAY, E. C. (1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-101-1-18 · Cited by 423 · see citing works
Danese, M. D., Ladenson, P. W., Meinert, C. L., & Powe, N. R. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.9.2993 · Cited by 423 · see citing works
Monzani, F., Caraccio, N., Kozàkowà, M., Dardano, A., Vittone, F., Virdis, A., Taddei, S., Palombo, C., & Ferrannini, E. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031669 · Cited by 399 · see citing works
Subclinical Hypothyroidism Is Mild Thyroid Failure and Should be Treated
McDermott, M. T., & Ridgway, E. C. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.10.7959 · Cited by 398 · see citing works
Meier, C., Staub, J.-J., Roth, C.-B., Guglielmetti, M., Kunz, M., Miserez, A. R., Drewe, J., Huber, P., Herzog, R. F. K., & Müller-Stich, B. P. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.10.7973 · Cited by 397 · see citing works
Walldius, G., & Jungner, I. (2004) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2003.01276.x · Cited by 395 · see citing works
Zulewski, H., Müller, B., Exer, P., Miserez, A. R., & Staub, J.-J. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.3.3810 · Cited by 389 · see citing works
Risk for Ischemic Heart Disease and All-Cause Mortality in Subclinical Hypothyroidism
Imaizumi, M., Akahoshi, M., Ichimaru, S., Nakashima, E., Hida, A., Soda, M., Usa, T., Ashizawa, K., Yokoyama, N., Maeda, R., et al. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031089 · Cited by 373 · see citing works
Danese, M. D., Ladenson, P. W., Meinert, C. L., et al. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6841 · Cited by 308 · see citing works
Caraccio, N., Ferrannini, E., & Monzani, F. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.4.8378 · Cited by 294 · see citing works
A 6-month randomized trial of thyroxine treatment in women with mild subclinical hypothyroidism
Kong, W. M., Sheikh, M. H., Lumb, P. J., Freedman, D. B., Crook, M. A., Doré, C. J., & Finer, N. (2002) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01022-7 · Cited by 223 · see citing works
Tunbridge, W. M. G., Evered, D. C., Hall, R., Appleton, D. R., BREWIS, M., CLARK, F., Evans, J. G., Young, E. T., Bird, T., & Smith, P. (1977) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1977.tb01341.x · Cited by 177 · see citing works
Tanis, B. C., Westendorp, R. G. J., & Smelt, A. H. M. (1996) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1996.739560.x · Cited by 177 · see citing works
Serum Calcium and Cardiovascular Risk Factors and Diseases
Jorde, R., Sundsfjord, J., Fitzgerald, P., & Bønaa, K. H. (1999) · Hypertension · doi:10.1161/01.hyp.34.3.484 · Cited by 141 · see citing works
Self-citationLipid profile in subclinical hypothyroidism: is L-thyroxine substitution beneficial?
Efstathiadou, Z. A., Bitsis, S., Milionis, H. J., Kukuvitis, A., Bairaktari, E. T., Elisaf, M., & Tsatsoulis, A. A. (2001) · European Journal of Endocrinology · doi:10.1530/eje.0.1450705 · Cited by 136 · see citing works
Bindels, A. J. G. H., Westendorp, R. G. J., Frölich, M., Seidell, J. C., Blokstra, A., & Smelt, A. H. M. (1999) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1999.00638.x · Cited by 99 · see citing works
Gullu, S., Sav, H., & Kamel, N. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01857 · Cited by 96 · see citing works
Prevalence and relevance of thyroid dysfunction in 1922 cholesterol screening participants
Pirich, C., Müllner, M., & Sinzinger, H. F. (2000) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(99)00187-0 · Cited by 90 · see citing works
Lee, W., Suh, J.-Y., Rhee, E., Park, J., Sung, K., & Kim, S.-W. (2004) · Archives of Medical Research · doi:10.1016/j.arcmed.2004.08.003 · Cited by 78 · see citing works
Lipoprotein(a) Concentration in Subclinical Hypothyroidism Before and After Levo-Thyroxine Therapy.
Yıldırımkaya, M., Özata, M., YILMAZ, K., Kılınç, C., Gündoğan, M. A., & Kutluay, T. (1996) · Endocrine Journal · doi:10.1507/endocrj.43.731 · Cited by 75 · see citing works
Effects of Subclinical Hypothyroidism and Its Treatment on Serum Lipids
Ineck, B. A., & Ng, T. M. H. (2003) · Annals of Pharmacotherapy · doi:10.1345/aph.1c376 · Cited by 65 · see citing works
Jorde, R., Bønaa, K. H., & Sundsfjord, J. (1999) · European Journal of Endocrinology · doi:10.1530/eje.0.1410350 · Cited by 59 · see citing works
Self-citationSerum parathyroid hormone (PTH) levels in smokers and non-smokers. The fifth Tromsø study
Jorde, R., Saleh, F., Figenschau, Y., Kamycheva, E., Haug, E., & Sundsfjord, J. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01816 · Cited by 58 · see citing works
Self-citationLipoprotein (a) levels, apolipoprotein (a) phenotypes and thyroid autoimmunity
Bairaktari, E. T., Tselepis, A. D., Millionis, H., & Elisaf, M. (1999) · European Journal of Endocrinology · doi:10.1530/eje.0.1400474 · Cited by 7 · see citing works
The importance of using strict inclusion criteria in subclinical hypothyroid studies
Biondi, B., Palmieri, E. A., Lombardi, G., & Fazio, S. (2003) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01260-3 · Cited by 5 · see citing works
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- e-mail: amjid.iqbal@unn.no). Ó 2006 Blackwell Publishing Ltd Journal of Internal Medicine 260: 53-61
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Garber, J. R., Cobin, R. H., Gharib, H., Hennessey, J. V., Klein, I., Mechanick, J. I., Pessah-Pollack, R., Singer, P. A., & Woeber, K. A. (2012) · Endocrine Practice · doi:10.4158/ep12280.gl · Cited by 1,567 · see citing works
The Clinical Significance of Subclinical Thyroid Dysfunction
Biondi, B., & Cooper, D. S. (2008) · Endocrine Reviews · doi:10.1210/er.2006-0043 · Cited by 1,418 · see citing works
Garber, J. R., Cobin, R. H., Gharib, H., Hennessey, J. V., Klein, I., Mechanick, J. I., Pessah-Pollack, R., Singer, P. A., & Woeber for the American Association, K. A. (2012) · Thyroid · doi:10.1089/thy.2012.0205 · Cited by 1,053 · see citing works
Thyroid hormones and cardiovascular disease
Jabbar, A., Pingitore, A., Pearce, S. H. S., Zaman, A., Iervasi, G., & Razvi, S. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.174 · Cited by 729 · see citing works
Thyroid Hormones and Cardiovascular Function and Diseases
Razvi, S., Jabbar, A., Pingitore, A., Danzi, S., Biondi, B., Klein, I., Peeters, R., Zaman, A., & Iervasi, G. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.02.045 · Cited by 515 · see citing works
Åsvold, B. O., Vatten, L. J., Nilsen, T. I. L., & Bjøro, T. (2007) · European Journal of Endocrinology · doi:10.1530/eje.1.02333 · Cited by 350 · see citing works
Razvi, S., Shakoor, A., Vanderpump, M., Weaver, J. U., & Pearce, S. H. S. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0167 · Cited by 330 · see citing works
Feller, M., Snel, M., Moutzouri, E., Bauer, D. C., de Montmollin, M., Aujesky, D., Ford, I., Gussekloo, J., Kearney, P. M., Mooijaart, S., et al. (2018) · JAMA · doi:10.1001/jama.2018.13770 · Cited by 266 · see citing works
Jorde, R., & Figenschau, Y. (2009) · European Journal of Nutrition · doi:10.1007/s00394-009-0020-3 · Cited by 244 · see citing works
Self-citationTseng, F.-Y., Lin, W.-Y., Lin, C.-C., Lee, L.-T., Li, T.-C., Sung, P.-K., & Huang, K.-C. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.03.047 · Cited by 212 · see citing works
Hypothyroidism in the elderly: diagnosis and management
Bensenor, I., Lotufo, P., & Diaz-Olmos (2012) · Clinical Interventions in Aging · doi:10.2147/cia.s23966 · Cited by 139 · see citing works
Heritability of serum TSH, free T4 and free T3 concentrations: a study of a large UK twin cohort
Panicker, V., Wilson, S. G., Spector, T. D., Brown, S. J., Falchi, M., Richards, J. B., Surdulescu, G. L., Lim, E. M., Fletcher, S. J., & Walsh, J. P. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.03079.x · Cited by 128 · see citing works
Lee, Y. K., Kim, J. E., Oh, H. J., Park, K. S., Kim, S. K., Park, S. W., Kim, M. J., & Cho, Y. W. (2011) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2011.26.4.432 · Cited by 100 · see citing works
Li, X., Wang, Y., Guan, Q., Zhao, J., & Gao, L. (2017) · Clinical Endocrinology · doi:10.1111/cen.13338 · Cited by 66 · see citing works
Interaction mechanisms between major depressive disorder and non-alcoholic fatty liver disease
Shao, Q., Wu, Y., Ji, J., Xu, T., Yu, Q., Ma, C., Liao, X., Cheng, F., & Wang, X. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.711835 · Cited by 32 · see citing works
Lombardi, C. P., Bocale, R., Barini, A., Barini, A., D’Amore, A., Boscherini, M., & Bellantone, R. (2017) · Endocrine · doi:10.1007/s12020-016-1003-9 · Cited by 23 · see citing works
- Authors
- IQBAL, A., JORDE, R., & FIGENSCHAU, Y.
- Affiliations
- University Hospital of North Norway (NO)
- UiT The Arctic University of Norway (NO)
- Corresponding author
- IQBAL, A.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2006-04-21
- Volume
- 260
- Issue
- 1
- Pages
- 53-61
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W2144225124
- Cited by
- 174
- References
- 30
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 3 · 2021: 7 · 2020: 6 · 2019: 9 · 2018: 8 · 2017: 10 · 2016: 16 · 2015: 9 · 2014: 16 · 2013: 12 · 2012: 19
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Universitetet i Tromsø
- EkstraStiftelsen Helse og Rehabilitering (Stiftelsen Dam)
- Norges Forskningsråd
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- subclinical hypothyroidism, thyroid-stimulating hormone, serum lipids, thyroxine therapy, total cholesterol, LDL cholesterol, apolipoprotein A-I, apolipoprotein B, triglycerides, HDL cholesterol, sex differences
- MeSH terms
- Adult, Aged, Aged, 80 and over, Apolipoproteins B, Cholesterol, Epidemiologic Methods, Female, Humans, Hypothyroidism, Lipids, Cholesterol, LDL, Male, Middle Aged, Sex Factors, Thyrotropin, Thyroxine
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