Serum TSH Level in Healthy Koreans and the Association of TSH with Serum Lipid Concentration and Metabolic Syndrome
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BACKGROUND/AIMS: The proper treatment of subclinical hypothyroidism and the normal range of serum thyroid stimulating hormone (TSH) concentration are intensely debated. However, few reports have investigated TSH concentrations in Asian ethnic groups. Therefore, the present study was designed to define the TSH reference range in a Korean population and to investigate the metabolic significance of TSH concentration. METHODS: We enrolled patients who underwent medical examination at the CHA Bundang Medical Center. Anthropometric data were evaluated, and serum TSH, free T4, and lipid profiles were assayed. RESULTS: A total of 7,270 subjects were included. Mean TSH concentration of the study population was 1.82 ± 0.95 mU/L, and we observed a sex-related difference in TSH concentration (male, 1.67 ± 0.87 mU/L; female, 2.02 ± 1.01 mU/L; p < 0.01). When the 2.5 and 97.5 percentiles were calculated, 95% TSH reference limits were 0.52-4.29 mU/L. TSH concentration was higher in elderly subjects, during winter, in postmenopausal women, and in obese males. Moreover, TSH showed significantly positive correlations with serum total cholesterol, triglyceride, and low density lipoprotein cholesterol regardless of sex, age, season, obesity, or menopausal status (all p < 0.01). Finally, TSH concentration was positively related to the prevalence of metabolic syndrome. CONCLUSIONS: We demonstrated the association between TSH concentration within the normal reference range and serum lipid levels. TSH concentration varies according to sex, age, season, and body mass index (only in males). Moreover, high normal TSH levels were significantly associated with an increased prevalence of metabolic syndrome, which may be of importance when evaluating subjects with high normal TSH concentration.
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Higher levels of TSH were associated with worsening of both blood pressure and lipid levels, although these effects were modest.
“In particular higher levels of TSH were associated with worsening of both blood pressure [58–60] and lipid levels [61, 62] although these effects were modest.”
From Age-related variation in thyroid function – a narrative review highlighting important implications for research and clinical practice (2023) · cites this paper as [62]
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Cites
Alberti, K. G. M. M., Zimmet, P., & Shaw, J. (2006) · Diabetic Medicine · doi:10.1111/j.1464-5491.2006.01858.x · Cited by 6,597 · see citing works
Hollowell, J. G., Staehling, N. W., Flanders, W. D., Hannon, W. H., Gunter, E. W., Spencer, C. A., & Braverman, L. E. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.2.489 · Cited by 4,279 · see citing works
Williams Textbook of Endocrinology
Melmed, S., & Polonsky, K. С. (2016) · Elsevier eBooks · doi:10.1016/c2013-0-15980-6 · Cited by 3,716 · see citing works
The Colorado Thyroid Disease Prevalence Study
Canaris, G. J., Manowitz, N. R., Mayor, G., & Ridgway, E. C. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.4.526 · Cited by 2,824 · see citing works
Thyroid hormone and the cardiovascular system.
Klein, I., & Ojamaa, K. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102153440707 · Cited by 2,300 · see citing works
Subclinical Thyroid Disease: Scientific Review and Guidelines for Diagnosis and Management
Surks, M. I., Ortiz, E., Daniels, G. H., Sawin, C. T., Col, N. F., Cobin, R. H., Franklyn, J. A., Hershman, J. M., Burman, K. D., Denke, M. A., et al. (2004) · JAMA · doi:10.1001/jama.291.2.228 · Cited by 1,800 · see citing works
Laboratory Support for the Diagnosis and Monitoring of Thyroid Disease
(2003) · Thyroid · doi:10.1089/105072503321086962 · Cited by 1,212 · see citing works
Use of Transesophageal Echocardiography to Guide Cardioversion in Patients with Atrial Fibrillation
Klein, A. L., Grimm, R. A., Murray, R. D., Apperson-Hansen, C., ASINGER, R. W., Black, I. W., Davidoff, R., Erbel, R., Halperin, J. L., Orsinelli, D. A., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105103441901 · Cited by 952 · see citing works
Duntas, L. H. (2002) · Thyroid · doi:10.1089/10507250252949405 · Cited by 725 · see citing works
Hypothyroidism and Atherosclerosis
Cappola, A. R., & Ladenson, P. W. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030398 · Cited by 640 · see citing works
Subclinical thyroid dysfunction as a risk factor for cardiovascular disease
Walsh, J. P., Bremner, A. P., Bulsara, M. K., O’Leary, P., Leedman, P. J., Feddema, P., & Michelangeli, V. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.21.2467 · Cited by 536 · see citing works
The Evidence for a Narrower Thyrotropin Reference Range Is Compelling
Wartofsky, L., & Dickey, R. A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0455 · Cited by 424 · see citing works
Subclinical Hypothyroidism Is Mild Thyroid Failure and Should be Treated
McDermott, M. T., & Ridgway, E. C. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.10.7959 · Cited by 398 · see citing works
Williams Textbook of Endocrinology
Niculescu, D. (2008) · Acta Endocrinologica (Bucharest) · doi:10.4183/aeb.2008.127 · Cited by 373 · see citing works
Caraccio, N., Ferrannini, E., & Monzani, F. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.4.8378 · Cited by 294 · see citing works
The Thyrotropin Reference Range Should Remain Unchanged
Surks, M. I., Goswami, G., & Daniels, G. H. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0170 · Cited by 287 · see citing works
Jorde, R., Waterloo, K. K., Storhaug, H. M., Nyrnes, A., Sundsfjord, J., & Jenssen, T. G. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1775 · Cited by 242 · see citing works
Spencer, C. A., Hollowell, J. G., Kazarosyan, M., & Braverman, L. E. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0287 · Cited by 227 · see citing works
IQBAL, A., JORDE, R., & FIGENSCHAU, Y. (2006) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01652.x · Cited by 174 · see citing works
Michalopoulou, G., Alevizaki, M., Piperingos, G. D., Mitsibounas, D. N., Mantzos, E., Adamopoulos, P., & Koutras, D. A. (1998) · European Journal of Endocrinology · doi:10.1530/eje.0.1380141 · Cited by 156 · see citing works
Kim, S., Kim, S., Park, K., Park, S., & Cho, Y. (2009) · Endocrine Journal · doi:10.1507/endocrj.k09e-049 · Cited by 76 · see citing works
Self-citationPersani, L., Terzolo, M., Asteria, C., Orlandi, F., Angeli, A., & Beck‐Peccoz, P. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.9.7673415 · Cited by 69 · see citing works
Thyroid function and postmenopause
Schindler, A. E. (2003) · Gynecological Endocrinology · doi:10.1080/gye.17.1.79.85 · Cited by 66 · see citing works
Effects of Subclinical Hypothyroidism and Its Treatment on Serum Lipids
Ineck, B. A., & Ng, T. M. H. (2003) · Annals of Pharmacotherapy · doi:10.1345/aph.1c376 · Cited by 65 · see citing works
Biochemical testing of thyroid function.
Klee, G., & Hay, I. D. (1997) · Endocrinology and metabolism clinics of North America (Print) · doi:10.1016/s0889-8529(05)70281-4 · Cited by 65 · see citing works
Optimal Thyrotropin Level: Normal Ranges and Reference Intervals Are Not Equivalent
Dickey, R. A., Wartofsky, L., & Feld, S. (2005) · Thyroid · doi:10.1089/thy.2005.15.1035 · Cited by 56 · see citing works
Serum TSH variability in normal individuals: the influence of time of sample collection.
Scobbo, R. R., VonDohlen, T. W., Hassan, M., & Islam, S. (2004) · PubMed · Cited by 45 · see citing works
Subclinical thyroid disease: consensus or conundrum?
Cooper, D. S. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02031.x · Cited by 37 · see citing works
Adverse effects of subclinical hyperthyroidism
Fatourechi, V. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06036-6 · Cited by 31 · see citing works
Reference Interval of Serum Thyroid Hormones in Healthy Korean Adults
Jang, Y., Kim, C., Hwang, T., Kim, K.-D., & Lee, C.-H. (2008) · Journal of Preventive Medicine and Public Health · doi:10.3961/jpmph.2008.41.2.128 · Cited by 17 · see citing works
Prevalence of abnormal thyroid function test and significance of TSH in health examination.
Sw, J., Sy, C., & Cho, J. J. (1993) · Gajeong yihag hoeji · Cited by 4 · see citing works
Flagged first, then by citations
1 of the 32 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Thyroid dysfunction and diabetes mellitus: two closely associated disorders
Biondi, B., Kahaly, G. J., & Robertson, R. P. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00163 · Cited by 598 · see citing works
A Review of the Clinical Consequences of Variation in Thyroid Function Within the Reference Range
Taylor, P. N., Razvi, S., Pearce, S. H., & Dayan, C. M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1315 · Cited by 274 · see citing works
Thyroid Hormones and the Metabolic Syndrome
Iwen, K. A., Schröder, E., & Brabant, G. E. (2013) · European Thyroid Journal · doi:10.1159/000351249 · Cited by 253 · see citing works
The role of thyroid hormone in metabolism and metabolic syndrome
Teixeira, P. D. F. D. S., dos Santos, P. B., & Pazos-Moura, C. C. (2020) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018820917869 · Cited by 248 · see citing works
Subclinical hypothyroidism, lipid metabolism and cardiovascular disease
Delitala, A., Fanciulli, G., Maioli, M., & Delitala, G. (2016) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2016.12.015 · Cited by 165 · see citing works
Thyroid Function in Human Obesity: Underlying Mechanisms
Fontenelle, L. F., Feitosa, M. F., Severo, J. S., Freitas, T., Morais, J. B. S., Torres‐Leal, F. L., Henriques, G. S., & Marreiro, D. D. N. (2016) · Hormone and Metabolic Research · doi:10.1055/s-0042-121421 · Cited by 138 · see citing works
Serum Free Thyroxine Concentration is Associated with Metabolic Syndrome in Euthyroid Subjects
Mehran, L., Amouzegar, A., Tohidi, M., Moayedi, M., & Azizi, F. (2014) · Thyroid · doi:10.1089/thy.2014.0103 · Cited by 117 · see citing works
Thyroid Function and Metabolic Syndrome: A Population-Based Thyroid Study
Mehran, L., Amouzegar, A., Rahimabad, P. K., Tohidi, M., Tahmasebinejad, Z., & Azizi, F. (2017) · Hormone and Metabolic Research · doi:10.1055/s-0042-117279 · Cited by 93 · see citing works
Jiaji, H., Lai, Y., Yang, J., Yao, Y., Li, Y., Teng, W., & Shan, Z. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.661160 · Cited by 80 · see citing works
Åsvold, B. O., Bjøro, T., & VATTEN, L. J. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0087 · Cited by 79 · see citing works
Taylor, P. N., Lansdown, A., Witczak, J., Khan, R., Rees, A., Dayan, C. M., & Okosieme, O. (2023) · Thyroid Research · doi:10.1186/s13044-023-00149-5 · Cited by 72 · see citing works
“In particular higher levels of TSH were associated with worsening of both blood pressure [58–60] and lipid levels [61, 62] although these effects were modest.”
BackgroundChang, Y., Hua, S., Chang, C., Kao, W.-Y., Lee, H.-L., Chuang, L., Huang, Y., & Lai, M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8060817 · Cited by 67 · see citing works
Low–normal thyroid function and the pathogenesis of common cardio‐metabolic disorders
van Tienhoven‐Wind, L. J. N., & Dullaart, R. P. F. (2015) · European Journal of Clinical Investigation · doi:10.1111/eci.12423 · Cited by 64 · see citing works
Thyroid disease and the metabolic syndrome
Mehran, L., Amouzegar, A., & Azizi, F. (2019) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000500 · Cited by 63 · see citing works
Subclinical Hypothyroidism and Cardiovascular Disease
Suh, S., & Kim, D. K. (2015) · Endocrinology and Metabolism · doi:10.3803/enm.2015.30.3.246 · Cited by 58 · see citing works
Jin, H. Y. (2018) · Journal of Paediatrics and Child Health · doi:10.1111/jpc.13926 · Cited by 54 · see citing works
Amouzegar, A., Delshad, H., Mehran, L., Tohidi, M., M.Khafaji, F., & Azizi, F. (2013) · PubMed · doi:10.3275/9033 · Cited by 53 · see citing works
Low-Normal Thyroid Function and Novel Cardiometabolic Biomarkers
van Tienhoven‐Wind, L. J. N., & Dullaart, R. P. F. (2015) · Nutrients · doi:10.3390/nu7021352 · Cited by 53 · see citing works
Yang, L., Lv, X., Yue, F., Wei, D., Liu, W., & Zhang, T. (2016) · Endocrine Research · doi:10.3109/07435800.2015.1108332 · Cited by 49 · see citing works
Palacios, S. S., Brugos‐Larumbe, A., Guillén‐Grima, F., & Galofré, J. C. (2013) · Clinical Endocrinology · doi:10.1111/cen.12216 · Cited by 45 · see citing works
Subclinical hypothyroidism and vascular risk: An update
Lioudaki, E., Mavroeidi, N., Mikhailidis, D. P., & Ganotakis, E. S. (2013) · HORMONES · doi:10.14310/horm.2002.1437 · Cited by 45 · see citing works
Kim, S., Kwon, Y. S., Kim, J. Y., Hong, K. H., & Park, Y. K. (2019) · Nutrients · doi:10.3390/nu11112757 · Cited by 45 · see citing works
Self-citationBenseñor, I. M., Goulart, A. C., Molina, M. D. C. B., de Miranda, É. J. P., Santos, I. S., & Lotufo, P. A. (2015) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2015.0045 · Cited by 37 · see citing works
Laclaustra, M., Hurtado-Roca, Y., Sendin, M., Leon, M., Ledesma, M., Andres, E. M., Fernández‐Ortíz, A., Güallar, E., Ordovás, J. M., & Casasnovas, J. A. (2015) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2015.09.007 · Cited by 35 · see citing works
Kim, H. J., Bae, J. C., Park, H. K., Byun, D. W., Suh, K., Yoo, M. H., Kim, J. H., Min, Y., Kim, S. W., & Chung, J. H. (2016) · Endocrinology and Metabolism · doi:10.3803/enm.2016.31.2.311 · Cited by 35 · see citing works
Self-citationDelitala, A., Scuteri, A., Fiorillo, E., Lakatta, E. G., Schlessinger, D., & Cucca, F. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8060764 · Cited by 35 · see citing works
Sex-Specific Associations Between Thyrotropin and Serum Lipid Profiles
Meisinger, C., Ittermann, T., Tiller, D., Agger, C., Nauck, M. A., Schipf, S., Wallaschofski, H., Jørgensen, T., Linneberg, A. R., Thiery, J., et al. (2013) · Thyroid · doi:10.1089/thy.2013.0259 · Cited by 28 · see citing works
Metabolic characteristics in obese patients complicated by mild thyroid hormone deficiency
Wang, X., Liu, H., Chen, J., Huang, Y., Li, L., Rampersad, S., & Qu, S. (2016) · Hormone and Metabolic Research · doi:10.1055/s-0042-105150 · Cited by 26 · see citing works
Aydogdu, A., Karakaş, E. Y., Erkuş, E., Altıparmak, İ. H., Şavik, E., Ulaş, T., & Sabuncu, T. (2017) · Archives of Medical Science · doi:10.5114/aoms.2017.65479 · Cited by 26 · see citing works
Ray, L., James, S., Ravichandran, K., & Nanda, S. K. (2016) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.190550 · Cited by 28 · see citing works
Kim, J. M., Kim, B. H., Lee, H., Kim, E. H., Kim, M., Kim, J. H., Jeon, Y. K., Kim, S. S., Kim, I. J., & Kim, Y. K. (2019) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2018.0130 · Cited by 23 · see citing works
Self-citationNiedoczynność tarczycy u pacjentów z zespołem metabolicznym
Gierach, M., & Junik, R. (2015) · Endokrynologia Polska · doi:10.5603/ep.2015.0036 · Cited by 21 · see citing works
Correlation Between Serum TSH Levels Within Normal Range and Serum Lipid Profile
Luxia, L., Jingfang, L., Fu, S., Xulei, T., Ma, L., Weiming, S., Niu, Y., Jing, G., Niu, Q., Li, Y., et al. (2020) · Hormone and Metabolic Research · doi:10.1055/a-1191-7953 · Cited by 20 · see citing works
Gu, Y., Wang, Y., Zhang, Q., Liu, L., Meng, G., Yao, Z., Wu, H., Xia, Y., Bao, X., Shi, H., et al. (2018) · Clinical Endocrinology · doi:10.1111/cen.13576 · Cited by 19 · see citing works
Shen, X., Yang, L., Liu, Y., Zhang, X.-H., Cai, P., Huang, J., & Jiang, L. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1153462 · Cited by 18 · see citing works
Kalinowska, S., Trześniowska-Drukała, B., Safranow, K., Pełka-Wysiecka, J., Kłoda, K., Misiak, B., & Samochowiec, J. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.02.029 · Cited by 17 · see citing works
Correlation between Subclinical Hypothyroidism and Metabolic Syndrome: A Retrospective Study
Alsulami, S., Baig, M., Albeladi, A., Alyoubi, S., Alsubaie, S. A., Albeladi, S. A., Ghamri, K. A., Alraiqi, A., Alyoubi, S., & Almutairi, W. A. (2023) · Saudi Journal of Medicine and Medical Sciences · doi:10.4103/sjmms.sjmms_225_22 · Cited by 17 · see citing works
Benseñor, I. M. (2019) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20198417 · Cited by 19 · see citing works
BMI Modulates the Effect of Thyroid Hormone on Lipid Profile in Euthyroid Adults
Wang, Y., Yin, Q., Xu, M., Ni, Q., Wang, W., & Wang, Q. (2017) · International Journal of Endocrinology · doi:10.1155/2017/8591986 · Cited by 16 · see citing works
Choi, W., Park, J. Y., Hong, A. R., Yoon, J. H., Kim, H. K., & Kang, H. (2021) · PLoS ONE · doi:10.1371/journal.pone.0254630 · Cited by 15 · see citing works
Obstetric outcomes in thyroid cancer survivors: A retrospective cohort study
Liu, D., Wei, Y., Zhao, Y., Li, R., Yan, J., & Qiao, J. (2020) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.13571 · Cited by 15 · see citing works
Kim, K., Park, S.-H., Choi, J., & Hwang, I.-U. (2024) · Environmental Research · doi:10.1016/j.envres.2024.119018 · Cited by 14 · see citing works
Self-citationKim, H. J., Bae, J. C., Park, H. K., Byun, D. W., Suh, K., Yoo, M. H., Jee, J. H., Kim, J. H., Min, Y., Kim, S. W., et al. (2017) · European Journal of Endocrinology · doi:10.1530/eje-16-0734 · Cited by 14 · see citing works
Self-citationIs Subclinical Hypothyroidism in Patients with Polycystic Ovary Syndrome Associated with BMI?
Yasar, H. (2016) · Acta Endocrinologica (Bucharest) · doi:10.4183/aeb.2016.431 · Cited by 14 · see citing works
Thyroid dysfunctions and sonographic characteristics in northern Turkey: a population-based study
Kutlutürk, F., Yildirim, B., Öztürk, B., Özyurt, H., Bekar, U., Şahin, Ş., Aktürk, Y., Akbaş, A., Etikán, Í., & Çetin, İ. (2013) · Annals of Saudi Medicine · doi:10.5144/0256-4947.2013.253 · Cited by 13 · see citing works
The association between anxiety and depression with 25(OH)D and thyroid stimulating hormone levels
Erensoy, H. (2019) · Neurosciences · doi:10.17712/nsj.2019.4.20190028 · Cited by 13 · see citing works
Association of thyroid-stimulating hormone with lipid concentrations: an 11-year longitudinal study
Langén, V. L., Niiranen, T., Puukka, P. J., Sundvall, J., & Jula, A. (2016) · Clinical Endocrinology · doi:10.1111/cen.13151 · Cited by 13 · see citing works
Aldossari, K. K., Al-Ghamdi, S. H., Alzahrani, J. M., Jammah, A. A., Alanazi, B. G., Albriek, A. Z., & Alanazi, M. A. (2019) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.22983 · Cited by 12 · see citing works
Recent review on medical treatment of thyroid disease
Park, K. H., & Lee, E. J. (2012) · Journal of Korean Medical Association · doi:10.5124/jkma.2012.55.12.1207 · Cited by 10 · see citing works
Self-citationZhang, T., Xia, Y., Han, T.-L., Zhang, H., & Baker, P. N. (2020) · Scientific Reports · doi:10.1038/s41598-020-63513-7 · Cited by 10 · see citing works
Choi, J. Y., Huh, D., & Moon, K. W. (2020) · PLoS ONE · doi:10.1371/journal.pone.0244821 · Cited by 10 · see citing works
Zhang, C., Wang, H., Li, Y., Wang, X., Han, Y., Gao, X., Lai, Y., Wang, C., Teng, W., & Shan, Z. (2024) · Endocrine · doi:10.1007/s12020-024-03858-5 · Cited by 9 · see citing works
Yang, S.-S., Tang, L., Li, R.-G., Ge, G., Qu, X., Ma, J.-W., Qiao, Z., Zhang, L., Liu, H., Hou, Y., et al. (2014) · PubMed · Cited by 9 · see citing works
An, Y. M., Moon, S. J., Kim, S. K., Suh, Y. J., & Lee, J. E. (2018) · Annals of Pediatric Endocrinology & Metabolism · doi:10.6065/apem.2018.23.3.141 · Cited by 9 · see citing works
Self-citationMa, S., Shao, S., Yang, C., Yao, Z., Gao, L., & Chen, W. (2020) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01210-y · Cited by 9 · see citing works
Tang, K., Zhang, Q., Peng, N., Zhang, M., Xu, S., Li, H., Hu, Y., Xue, C., Shi, L., & the REACTION Study Group (2020) · Journal of International Medical Research · doi:10.1177/0300060520966878 · Cited by 8 · see citing works
Thyroid hormone levels are associated with metabolic components: a cross-sectional study
Punda, A., Škrabić, V., Torlak, V., Gunjača, I., Perica, V. B., Perica, Kolčić, I., Polašek, O., Hayward, C., Zemunik, T., et al. (2020) · Croatian Medical Journal · doi:10.3325/cmj.2020.61.230 · Cited by 8 · see citing works
Kwon, B., Roh, J.-W., Lee, S.-H., Lim, S., Park, C., Kim, D., Jang, S.-W., Chang, K., Kim, H.-Y., & Ihm, S. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.09.200 · Cited by 8 · see citing works
Folate Receptor Alpha Autoantibodies Modulate Thyroid Function in Autism Spectrum Disorder
Frye, R. E., Sequeira, J. M., Quadros, E. V., & Rossignol, D. A. (2014) · North American Journal of Medicine and Science · doi:10.7156/najms.2014.0702053 · Cited by 8 · see citing works
The Association Between Normal Range TSH and Lipid Profile
Ahi, S., Amouzegar, A., Gharibzadeh, S., Kazempour‐Ardebili, S., Delshad, H., Tohidi, M., & Azizi, F. (2017) · Hormone and Metabolic Research · doi:10.1055/s-0043-110142 · Cited by 8 · see citing works
Lozanov, L. B., Gorcheva, D., Lozanov, B., Argirova, R., Koleva, V., Kostova, B., Borisov, R., & Nedeva, M. (2017) · Hormone and Metabolic Research · doi:10.1055/s-0043-115532 · Cited by 6 · see citing works
Nozarian, Z., Abdollahi, A., Mehrtash, V., & Bonaki, H. N. (2017) · Iranian journal of pathology · doi:10.30699/ijp.2017.24219 · Cited by 6 · see citing works
Choe, H. J., Choi, Y. M., Ha, Y., Kim, J., Kim, M., Cha, H. J., Lee, J., Kwak, M. K., & Hong, E. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf046 · Cited by 4 · see citing works
Self-citationSubclinical Hypothyroidism and the Alterations of Lipid Profile as a Cardiovascular Risk Factor
Maleki, N., Kazerouni, F., Hedayati, M., Rahimipour, A., & Parham, M. (2015) · Archives of Advances in Biosciences · doi:10.22037/jps.v6i4.10623 · Cited by 5 · see citing works
Взаємозв’язок між компонентами метаболічного синдрому у хворих на ожиріння
Баянова, Е. Г. (2017) · INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) · doi:10.22141/2224-0721.13.2.2017.100615 · Cited by 5 · see citing works
Congenital and acquired hypothyroidism: Temporal and spatial trends in France from 2014 to 2019
Chamot, S., Al‐Salameh, A., Balcaen, T., Petit, P., Bonneterre, V., Cancé, C., & Desailloud, R. (2024) · Annals of Epidemiology · doi:10.1016/j.annepidem.2024.07.091 · Cited by 4 · see citing works
Hypothyroidism and the Metabolic Syndrome
Kannan, L. (2017) · Endocrinology&Metabolism International Journal · doi:10.15406/emij.2017.05.00115 · Cited by 4 · see citing works
Different novel biomarkers involved in diagnosing hypothyroidism
Sharma, H., & Kakadiya, J. (2023) · The Egyptian Journal of Internal Medicine · doi:10.1186/s43162-023-00214-3 · Cited by 4 · see citing works
Zihni, İ., Soysal, V., Uslu, A., Zengel, B., Okut, G., Aykas, A., Duran, A., & Tatar, E. (2018) · Turkish Journal of Surgery · doi:10.5152/turkjsurg.2018.3746 · Cited by 4 · see citing works
Thyroid Metabolic Hormones and its Correlation with BMI and Lipid Profile in Healthy People
Natah, T. M., Wtwt, M. A.-A., Hadi, M. A., Farhood, H. F., Zaidan, H. K., & Al-Saadi, A. H. (2013) · Journals & Books Hosting (International Knowledge Sharing Platform) · Cited by 4 · see citing works
Pezeshki, B., Pourmontaseri, H., Homayounfar, R., Moghaddam, M. T., & Dehghan, A. (2023) · BMC Endocrine Disorders · doi:10.1186/s12902-023-01467-3 · Cited by 3 · see citing works
Liu, F., Feng, J., Hao, M., Wang, X., Pan, N., Zhang, G., Jiang, C., Shang, X., Ling, Y., Xiao, Z., et al. (2023) · Annals of Translational Medicine · doi:10.21037/atm-22-6374 · Cited by 3 · see citing works
Prevalence of metabolic syndrome in hypothyroid patients under Levothyroxine therapy
Takır, M., & Kızılgül, M. (2018) · Medeniyet Medical Journal · doi:10.5222/mmj.2018.02700 · Cited by 3 · see citing works
Chen, S., Yuan, J., Qiao, S., Tian, Y., Duan, F., Hu, F., Yang, W., Zhou, C., Yang, X., & Yang, Y. (2013) · Kardiologia Polska · doi:10.5603/kp.2013.0007 · Cited by 3 · see citing works
Quelle pertinence accorder au taux circulant de TSH ?
Donadio, S., Chikh, K., Iss, C., Kuczewski, E., Gauchez, A., Ronin, C., & Charrié, A. (2013) · Immuno-analyse & Biologie Spécialisée · doi:10.1016/j.immbio.2013.03.007 · Cited by 3 · see citing works
Lipid Profile Change after Thyroidectomy
Chu, C., Kim, S. Y., Lee, Y. S., & Chang, H. (2020) · Journal of Endocrine Surgery · doi:10.16956/jes.2020.20.3.41 · Cited by 2 · see citing works
Self-citationKim, S. S., Lew, D. H., Choi, J. Y., Lee, E., Kim, M. G., Kim, K. Y., Kim, S. K., Jung, J. H., Jung, J. H., & Hahm, J. R. (2014) · Kosin Medical Journal · doi:10.7180/kmj.2014.29.2.125 · Cited by 1 · see citing works
Self-citationBENEFICIAL EFFECTS OF LEVOTHYROXINE IN THE TREATMENT OF SUBCLINICAL HYPOTHYROIDISM
Mulić, M., Halo, O., Škrijelj, F., & Mulić, B. (2016) · SANAMED · doi:10.24125/sanamed.v11i3.130 · Cited by 1 · see citing works
Do TSH Levels in Euthyroid Patients have an Impact on the Prevalence of Metabolic Syndrome
Balkan, F., Usluogullari, A. C., & Üçler, R. (2015) · Endocrinology research and practice. · doi:10.4274/tjem.2610 · Cited by 1 · see citing works
Современные представления о синдроме эутиреоиднои патологии в клинической практике
Abramova, N., & Pashkovska, N. V. (2017) · Likarska sprava · doi:10.31640/ls-2017(1-2)04 · Cited by 1 · see citing works
Yang, M., Wei, Y., Wang, Y., Liu, J., & Wang, G. (2024) · HORMONES · doi:10.1007/s42000-024-00596-1 · Cited by 1 · see citing works
Dong, H., Hu, P., Wang, J., & Lu, N. (2025) · BMC Cardiovascular Disorders · doi:10.1186/s12872-025-05103-x · Cited by 1 · see citing works
"High normal" thyroid stimulating hormone: does it matter?
Chun, H., & Song, K. (2013) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2013.28.2.162 · Cited by 1 · see citing works
Glycaemic regulation and metabolic syndrome: A reference to thyroid function state
Pandit, A., & Pandey, A. K. (2016) · Scholars Journal of Applied Medical Sciences · doi:10.21276/sjams.2016.4.6.7
Correlation between Thyrotropin and Fasting Lipid Profile in Patients of Sub Clinical Hypothyroidism
Zubair, S. M., Ijaz, F., & Aftab, R. K. (2017) · Annals of King Edward Medical University · doi:10.21649/akemu.v23i2.1568
Faut-il faire un dosage systématique de la TSH à l’admission en court séjour gériatrique ?
Kobeh, D., Janin, H., Regueme, S. C., & Bourdel‐Marchasson, I. (2017) · NPG. Neurologie, psychiatrie, gériatrie/NPG · doi:10.1016/j.npg.2017.05.007
Kim, H. J., Park, H. K., Byun, D. W., Suh, K., Yoo, M. H., Kim, J. H., Min, Y., Kim, S. W., & Chung, J. H. (2015) · Endocrine Abstracts · doi:10.1530/endoabs.37.ep1034
Self-citationLoviselli, A., Sainas, G., Magnani, S., Secci, G., Pisanu, S., Deledda, A., Boi, A., Lai, D., & Velluzzi, F. (2018) · Journal of Endocrinology and Diabetes · doi:10.15226/2374-6890/5/2/001100
吴, 晓. (2018) · Advances in Clinical Medicine · doi:10.12677/acm.2018.87101
Babu, V. S., Ramaswamy, C., & Chakravarthy, V. K. (2018) · International Journal of Research in Medical Sciences · doi:10.18203/2320-6012.ijrms20185394
A Comparative Study of Thyroid Profile in Individuals with and Without Metabolic Syndrome
Deb, S. (2020) · Journal of Medical Science And clinical Research · doi:10.18535/jmscr/v8i3.04
Pekcan, M. K., Pekcan, G., & Özakşit, G. (2021) · Kocaeli Medical Journal · doi:10.5505/ktd.2021.00086
A CROSS -SECTIONAL STUDY OF METABOLIC SYNDROME IN HYPOTHYROID PATIENTS
Shukla, A. (2022) · INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH · doi:10.36106/ijsr/4506532
Kumar, S., Masood, T., Bhaskar, N., Shah, A. K., & Tangri, P. (2022) · International Journal of Health Sciences · doi:10.53730/ijhs.v6ns6.12603
Studying of Thyroid Dysfunction on Patients with Metabolic Syndrome
Saeed, M. A. (2023) · Journal of Prevention Diagnosis and Management of Human Diseases · doi:10.55529/jpdmhd.35.26.30
Síndrome metabólico e hipotiroidismo: un estudio transversal en una población ecuatoriana
Tene, D. M., Congacha, J. G. R., & Pedreáñez, A. B. (2024) · Revista Virtual de la Sociedad Paraguaya de Medicina Interna · doi:10.18004/rvspmi/2312-3893/2024.e11122406
Chang, J. Y., Kim, J. K., & Hong, S. H. (2024) · American journal of biochemistry & biotechnology/American journal of biochemistry and biotechnology · doi:10.3844/ajbbsp.2024.243.249
Self-citationThe effect of periodontal status on the TSH and FT4 levels
Üner, D. D., & İzol, B. S. (2024) · Journal of Oral Health and Oral Epidemiology · doi:10.34172/johoe.2202.1456
Mise en oeuvre de dosages pour le diagnostic précoce de l'hypothyroïdie
Iss, C. (2015) · theses.fr (ABES) · doi:10.70675/f9f2aeebza5a8z4cf3zb9afzd52e7504b286
- Authors
- Lee, Y. K., Kim, J. E., Oh, H. J., Park, K. S., Kim, S. K., Park, S. W., Kim, M. J., & Cho, Y. W.
- Affiliations
- CHA University (KR)
- Corresponding author
- Cho, Yong Wook
- Venue
- The Korean Journal of Internal Medicine
- Published
- 2011
- Volume
- 26
- Issue
- 4
- Pages
- 432
- ISSN
- 1226-3303 (ISSN-L)
- 2005-6648
- PMC
- PMC3245392
- OpenAlex
- W2158811811
- Cited by
- 100
- References
- 32
- Citations by year
- 2025: 2 · 2024: 7 · 2023: 7 · 2022: 2 · 2021: 3 · 2020: 10 · 2019: 11 · 2018: 8 · 2017: 12 · 2016: 10 · 2015: 10 · 2014: 5 · 2013: 12 · 2012: 1
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- The Korean Journal of Internal Medicine (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- thyroid-stimulating hormone, TSH reference range, serum lipids, metabolic syndrome, subclinical hypothyroidism, sex differences, seasonal variation, obesity, postmenopausal women, total cholesterol, triglycerides, LDL cholesterol, healthy adults
- MeSH terms
- Adult, Aged, Aged, 80 and over, Analysis of Variance, Cross-Sectional Studies, Ethnicity, Female, Humans, Korea, Lipids, Male, Menopause, Middle Aged, Thyroid Function Tests, Thyrotropin, Body Mass Index, Risk Assessment, Metabolic Syndrome, Young Adult
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