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Mid‐life adiposity factors relate to blood–brain barrier integrity in late life
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Abstract. Gustafson DR, Karlsson C, Skoog I, Rosengren L, Lissner L, Blennow K (Gothenburg University, Gothenburg, Sweden; and Medical College of Wisconsin, Milwaukee, WI, USA). Mid‐life adiposity factors relate to blood–brain barrier integrity in late life. J Intern Med 2007; 262: 643–650. Objective. We explored the relationship between adiposity factors measured during mid‐life and blood–brain barrier (BBB) integrity measured via the cerebrospinal fluid/serum (CSF/S) albumin ratio in late life. Adiposity factors included body mass index and blood levels of sex hormone binding globulin (SHBG) and leptin. Design. Retrospective analyses over 24 years within a longitudinal study. Setting. Population‐based sample. Subjects. Eighty‐one women. Main outcome measures. CSF/S albumin ratio. Results. The CSF/S albumin ratio measured at age 70–84 years was higher amongst women who were overweight or obese (6.50 ± 2.79 vs. 5.23 ± 1.61, age‐adjusted P = 0.012), and was inversely correlated with SHBG (age‐adjusted r = −0.321, P < 0.005) at age 46–60 years. In stepwise regression models, SHBG predicted the CSF/S albumin ratio (beta = −0.017, R2 = 0.107, P = 0.007). The best model (R2 = 0.187) predicting CSF/S albumin ratio included SHBG, age group (age 46 years versus >46), overweight or obesity, and an age group by SHBG interaction. Conclusions. Lower levels of SHBG in mid‐life were related to worse BBB integrity in women after 24 years in late life, even considering other adiposity factors. SHBG may be important for understanding sex hormone‐mediated mechanisms in brain health or as an independent marker of adipose tissue, the largest endocrine organ.
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“Body mass index measured in midlife is more strongly associated with VCI, whereas body weight measured later in life has an inverse association with cognitive impairment, where obesity is associated with a lower risk of dementia.320”
From Vascular Contributions to Cognitive Impairment and Dementia: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association (2011) · cites this paper as [320]
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Metadata
- Authors
- Gustafson, D. R., Karlsson, C., Skoog, I., Rosengren, L., Lissner, L., & Blennow, K.
- Affiliations
- Medical College of Wisconsin (US)
- University of Gothenburg (SE)
- Corresponding author
- Gustafson, D. R.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2007-11-15
- Volume
- 262
- Issue
- 6
- Pages
- 643-650
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W1563616747
- Cited by
- 107
- References
- 48
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 5 · 2022: 7 · 2021: 12 · 2020: 8 · 2019: 13 · 2018: 4 · 2017: 8 · 2016: 6 · 2015: 7 · 2014: 6 · 2013: 3 · 2012: 3
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alzheimer's Association (ZEN‐01‐3151, IIRG‐00‐2159)
- Forskningsrådet för Arbetsliv och Socialvetenskap (ZEN-01-3151, IIRG-00-2159)
- Vetenskapsrådet (11267)
- Swedish Brain Power (11267)
- National Institutes of Health (1r03ag026098-01a1)
- National Institute on Aging (1R03AG026098)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- blood-brain barrier integrity, CSF/serum albumin ratio, sex hormone-binding globulin, leptin, body mass index, obesity, overweight, women, aging, sex hormones, brain health
- MeSH terms
- Aged, Aged, 80 and over, Albumins, Blood-Brain Barrier, Female, Humans, Middle Aged, Obesity, Retrospective Studies, Serum Albumin, Sex Hormone-Binding Globulin, Biomarkers, Linear Models, Leptin, Overweight
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