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Mid‐life adiposity factors relate to blood–brain barrier integrity in late life
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Abstract. Gustafson DR, Karlsson C, Skoog I, Rosengren L, Lissner L, Blennow K (Gothenburg University, Gothenburg, Sweden; and Medical College of Wisconsin, Milwaukee, WI, USA). Mid‐life adiposity factors relate to blood–brain barrier integrity in late life. J Intern Med 2007; 262: 643–650. Objective. We explored the relationship between adiposity factors measured during mid‐life and blood–brain barrier (BBB) integrity measured via the cerebrospinal fluid/serum (CSF/S) albumin ratio in late life. Adiposity factors included body mass index and blood levels of sex hormone binding globulin (SHBG) and leptin. Design. Retrospective analyses over 24 years within a longitudinal study. Setting. Population‐based sample. Subjects. Eighty‐one women. Main outcome measures. CSF/S albumin ratio. Results. The CSF/S albumin ratio measured at age 70–84 years was higher amongst women who were overweight or obese (6.50 ± 2.79 vs. 5.23 ± 1.61, age‐adjusted P = 0.012), and was inversely correlated with SHBG (age‐adjusted r = −0.321, P < 0.005) at age 46–60 years. In stepwise regression models, SHBG predicted the CSF/S albumin ratio (beta = −0.017, R2 = 0.107, P = 0.007). The best model (R2 = 0.187) predicting CSF/S albumin ratio included SHBG, age group (age 46 years versus >46), overweight or obesity, and an age group by SHBG interaction. Conclusions. Lower levels of SHBG in mid‐life were related to worse BBB integrity in women after 24 years in late life, even considering other adiposity factors. SHBG may be important for understanding sex hormone‐mediated mechanisms in brain health or as an independent marker of adipose tissue, the largest endocrine organ.
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“Body mass index measured in midlife is more strongly associated with VCI, whereas body weight measured later in life has an inverse association with cognitive impairment, where obesity is associated with a lower risk of dementia.320”
From Vascular Contributions to Cognitive Impairment and Dementia: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association (2011) · cites this paper as [320]
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Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Diagnostic and Statistical Manual of Mental Disorders
&NA; (1988) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-198802020-00022 · Cited by 12,603
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults
Calle, E. E., Rodriguez, C., Walker-Thurmond, K., & Thun, M. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021423 · Cited by 7,696
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., et al. (1995) · Nature Medicine · doi:10.1038/nm1195-1155 · Cited by 3,725
Blennow, K., de Leon, M. J., & Zetterberg, H. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69113-7 · Cited by 3,134
Self-citationDing, E. L., Song, Y., Malik, V. S., & Liu, S. (2006) · JAMA · doi:10.1001/jama.295.11.1288 · Cited by 1,354
A COMPREHENSIVE PSYCHOPATHOLOGICAL RATING SCALE
Åsberg, M., Montgomery, S., Perris, C., Schalling, D., & Sedvall, G. (1978) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1978.tb02357.x · Cited by 1,327
Obesity and Vascular Risk Factors at Midlife and the Risk of Dementia and Alzheimer Disease
Kivipelto, M., Ngandu, T., Fratiglioni, L., Viitanen, M., Kåreholt, I., Winblad, B., Helkala, E.-L., Tuomilehto, J., Soininen, H., & Nissinen, A. (2005) · Archives of Neurology · doi:10.1001/archneur.62.10.1556 · Cited by 1,291
Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study
Whitmer, R. A., Gunderson, E. P., Barrett-Connor, E., Quesenberry, C. P., & Yaffe, K. (2005) · BMJ · doi:10.1136/bmj.38446.466238.e0 · Cited by 1,090
An 18-Year Follow-up of Overweight and Risk of Alzheimer Disease
Gustafson, D., Rothenberg, E., Blennow, K., Steen, B., & Skoog, I. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.13.1524 · Cited by 811
Self-citationAdiponectin acts in the brain to decrease body weight
Qi, Y., Takahashi, N., Hileman, S. M., Patel, H. R., Berg, A. H., Pajvani, U. B., Scherer, P. E., & Ahima, R. S. (2004) · Nature Medicine · doi:10.1038/nm1029 · Cited by 809
A Population-Based Study of Dementia in 85-Year-Olds
Skoog, I. G., Nilsson, L., Palmertz, B., Andreasson, L., & Svanborg, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199301213280301 · Cited by 692
Self-citationBlood-brain barrier transport of cytokines: a mechanism for neuropathology
Banks, W. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053381684 · Cited by 534
A 24-year follow-up of body mass index and cerebral atrophy
Gustafson, D., Lissner, L., Bengtsson, C., Björkelund, C., & Skoog, I. G. (2004) · Neurology · doi:10.1212/01.wnl.0000141850.47773.5f · Cited by 342
Self-citationLink, H., & Tibbling, G. (1977) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365517709091498 · Cited by 332
THE STUDY OF WOMEN IN GOTHENBURG 1968–1969 —A POPULATION STUDY
Bengtsson, C., Blohmé, G., Hallberg, L., Hällström, T., Isaksson, B., Korsan-Bengtsen, K., Rybo, G., Tibblin, E., Tibblin, G., & Westerberg, H. (1973) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1973.tb10583.x · Cited by 318
Link, H., & Tibbling, G. (1977) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365517709091498 · Cited by 306
Lathe, R. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1690205 · Cited by 278
Lindstedt, G., Lundberg, P.-A., Lapidus, L., Lundgren, H., Bengtsson, C., & Björntorp, P. (1991) · Diabetes · doi:10.2337/diab.40.1.123 · Cited by 252
A population study on blood-brain barrier function in 85-year-olds
Skoog, I. G., Wallin, A., Fredman, P., Hesse, C., Aevarsson, Ó., Karlsson, I., Gottfries, C. G., & Blennow, K. (1998) · Neurology · doi:10.1212/wnl.50.4.966 · Cited by 238
Self-citationAdiposity indices and dementia
Gustafson, D. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70526-9 · Cited by 237
Self-citationBody Mass Index, Other Cardiovascular Risk Factors, and Hospitalization for Dementia
Rosengren, A. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.3.321 · Cited by 207
Blood-brain barrier disturbance in patients with Alzheimer's disease is related to vascular factors
Blennow, K., Wallin, A., Fredman, P., Karlsson, I., Gottfries, C. G., & Svennerholm, L. T. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1990.tb01563.x · Cited by 184
Self-citationMemory inhibition and energy regulation
Davidson, T. L., Kanoski, S. E., Walls, E. K., & Jarrard, L. E. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.09.004 · Cited by 183
Body weight is regulated by the brain: a link between feeding and emotion
Kishi, T., & Elmquist, J. K. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001638 · Cited by 183
Reduced testosterone and adrenal C19 steroid levels in obese men
Tchernof, A., Després, J.-P., Bélanger, A., Dupont, A., Prud'homme, D., Moorjani, S., Lupien, P. J., & Labrie, F. (1995) · Metabolism · doi:10.1016/0026-0495(95)90060-8 · Cited by 175
Grishkovskaya, I., Avvakumov, G. V., Sklenar, G., Dales, D. W., Hammond, G. L., & Muller, Y. A. (2000) · The EMBO Journal · doi:10.1093/emboj/19.4.504 · Cited by 170
Leptin: a potential cognitive enhancer?
Harvey, J., Shanley, L. J., O'Malley, D., & Irving, A. J. (2005) · Biochemical Society Transactions · doi:10.1042/bst0331029 · Cited by 162
Kalish, G., Barrett-Connor, E. L., Laughlin, G. A., & Gulanski, B. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021375 · Cited by 155
The epidemiologic study of dementia: a life-long quest?
Launer, L. J. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.03.016 · Cited by 142
Bengtsson, C., Ahlqwist, M., Andersson, K., Björkelund, C., Lissner, L., & Söderström, M. (1997) · Scandinavian Journal of Primary Health Care · doi:10.3109/02813439709035031 · Cited by 139
Self-citationEstradiol causes the rapid accumulation of cAMP in human prostate.
Nakhla, A. M., Khan, M., Romas, N. P., & Rosner, W. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.12.5402 · Cited by 131
Lapidus, L., Lindstedt, G., Lundberg, P. A., Bengtsson, C., & Gredmark, T. (1986) · Clinical Chemistry · doi:10.1093/clinchem/32.1.146 · Cited by 130
Body mass index and white matter lesions in elderly women. An 18-year longitudinal study
Gustafson, D., Steen, B., & Skoog, I. G. (2004) · International Psychogeriatrics · doi:10.1017/s1041610204000353 · Cited by 117
Self-citationBanks, W. A. (2003) · Current Pharmaceutical Design · doi:10.2174/1381612033455350 · Cited by 101
Heiss, C. J., Sanborn, C. F., Nichols, D., Bonnick, S. L., & Alford, B. B. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.5.7745005 · Cited by 94
Wallin, A., Sjögren, M. J. C., Edman, Å., Blennow, K., & Regland, B. (2000) · European Neurology · doi:10.1159/000008242 · Cited by 94
Self-citationThe Population Study of Women in Gothenburg 1980–81—the Third Phase of a Longitudinal Study
Bengtsson, C., Gredmark, T., Hallberg, L., Hällstrüm, T., Isaksson, B., Lapidus, L., Lindquist, O., Lindstedt, S., Lurie, M., Nystrüm, E., et al. (1989) · Scandinavian Journal of Social Medicine · doi:10.1177/140349488901700203 · Cited by 89
Lissner, L., Karlsson, C., Lindroos, A. K., Sjöström, L., Carlsson, B., Carlsson, L. M. S., & Bengtsson, C. (1999) · Obesity Research · doi:10.1002/j.1550-8528.1999.tb00696.x · Cited by 84
Self-citationProtein Analyses in Cerebrospinal Fluid
Blennow, K., Fredman, P., Wallin, A., Gottfries, C., Långström, G., & Svennerholm, L. T. (2008) · European Neurology · doi:10.1159/000116918 · Cited by 81
Self-citationGrishkovskaya, I., Avvakumov, G. V., Hammond, G. L., Catalano, M. G., & Muller, Y. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203999200 · Cited by 73
Palsson, S. P., Larsson, L., Tengelin, E. G., Wærn, M., Samuelsson, S., Hällström, T., & Skoog, I. G. (2001) · Psychological Medicine · doi:10.1017/s0033291799003050 · Cited by 46
Self-citationThe Blood-Brain Barrier and Blood-Cerebral Spinal Fluid Barrier
Moody, D. M. (2006) · Seminars in Cardiothoracic and Vascular Anesthesia · doi:10.1177/1089253206288992 · Cited by 41
Identification of Sex Hormone-Binding Globulin in the Human Hypothalamus
Herbert, Z., Göthe, S. M., Caldwell, J. D., Bernstein, H., Melle, C., von Eggeling, F., Lewis, J. G., & Jirikowski, G. F. (2005) · Neuroendocrinology · doi:10.1159/000088170 · Cited by 31
Anthropometric data in middle-aged women. The population study of women in Göteborg 1968-1969.
Bengtsson, C., Hallberg, L., Noppa, H., & Tibblin, E. (1979) · PubMed · Cited by 15
Fortunati, N., Comba, A., Becchis, M., Catalano, M. G., Fazzari, A., Fissore, F., & Frairia, R. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb16262.x · Cited by 6
Research works printed but not linked: 2
- 10.1210/jc.80.5.1591 · DOI
- 10.1042/BST20051029 · DOI · Paper page
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Western diet consumption and cognitive impairment: Links to hippocampal dysfunction and obesity
Kanoski, S. E., & Davidson, T. L. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.12.003 · Cited by 710
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Nguyen, J. C. D., Killcross, S., & Jenkins, T. A. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00375 · Cited by 440
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Metadata
- Authors
- Gustafson, D. R., Karlsson, C., Skoog, I., Rosengren, L., Lissner, L., & Blennow, K.
- Affiliations
- Medical College of Wisconsin (US)
- University of Gothenburg (SE)
- Corresponding author
- Gustafson, D. R.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2007-11-15
- Volume
- 262
- Issue
- 6
- Pages
- 643-650
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W1563616747
- Cited by
- 107
- References
- 48
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 5 · 2022: 7 · 2021: 12 · 2020: 8 · 2019: 13 · 2018: 4 · 2017: 8 · 2016: 6 · 2015: 7 · 2014: 6 · 2013: 3 · 2012: 3
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alzheimer's Association (ZEN‐01‐3151, IIRG‐00‐2159)
- Forskningsrådet för Arbetsliv och Socialvetenskap (ZEN-01-3151, IIRG-00-2159)
- Vetenskapsrådet (11267)
- Swedish Brain Power (11267)
- National Institutes of Health (1r03ag026098-01a1)
- National Institute on Aging (1R03AG026098)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- blood-brain barrier integrity, CSF/serum albumin ratio, sex hormone-binding globulin, leptin, body mass index, obesity, overweight, women, aging, sex hormones, brain health
- MeSH terms
- Aged, Aged, 80 and over, Albumins, Blood-Brain Barrier, Female, Humans, Middle Aged, Obesity, Retrospective Studies, Serum Albumin, Sex Hormone-Binding Globulin, Biomarkers, Linear Models, Leptin, Overweight
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