Cited by 107Barrier Structure and Function StudiesAdipokines, Inflammation, and Metabolic DiseasesMenopause: Health Impacts and Treatments

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Mid‐life adiposity factors relate to blood–brain barrier integrity in late life

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Gustafson, D. R., Karlsson, C., Skoog, I., Rosengren, L., Lissner, L., Blennow, K.·2007·Journal of Internal Medicine

DOI 10.1111/j.1365-2796.2007.01869.x

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Abstract. Gustafson DR, Karlsson C, Skoog I, Rosengren L, Lissner L, Blennow K (Gothenburg University, Gothenburg, Sweden; and Medical College of Wisconsin, Milwaukee, WI, USA). Mid‐life adiposity factors relate to blood–brain barrier integrity in late life. J Intern Med 2007; 262: 643–650. Objective. We explored the relationship between adiposity factors measured during mid‐life and blood–brain barrier (BBB) integrity measured via the cerebrospinal fluid/serum (CSF/S) albumin ratio in late life. Adiposity factors included body mass index and blood levels of sex hormone binding globulin (SHBG) and leptin. Design. Retrospective analyses over 24 years within a longitudinal study. Setting. Population‐based sample. Subjects. Eighty‐one women. Main outcome measures. CSF/S albumin ratio. Results. The CSF/S albumin ratio measured at age 70–84 years was higher amongst women who were overweight or obese (6.50 ± 2.79 vs. 5.23 ± 1.61, age‐adjusted P = 0.012), and was inversely correlated with SHBG (age‐adjusted r = −0.321, P < 0.005) at age 46–60 years. In stepwise regression models, SHBG predicted the CSF/S albumin ratio (beta = −0.017, R2 = 0.107, P = 0.007). The best model (R2 = 0.187) predicting CSF/S albumin ratio included SHBG, age group (age 46 years versus >46), overweight or obesity, and an age group by SHBG interaction. Conclusions. Lower levels of SHBG in mid‐life were related to worse BBB integrity in women after 24 years in late life, even considering other adiposity factors. SHBG may be important for understanding sex hormone‐mediated mechanisms in brain health or as an independent marker of adipose tissue, the largest endocrine organ.

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“Mini-mental state”
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Diagnostic and Statistical Manual of Mental Disorders
&NA; (1988) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-198802020-00022 · Cited by 12,603
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults
Calle, E. E., Rodriguez, C., Walker-Thurmond, K., & Thun, M. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021423 · Cited by 7,696
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., et al. (1995) · Nature Medicine · doi:10.1038/nm1195-1155 · Cited by 3,725
Alzheimer’s disease
Blennow, K., de Leon, M. J., & Zetterberg, H. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69113-7 · Cited by 3,134
Self-citation
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Ding, E. L., Song, Y., Malik, V. S., & Liu, S. (2006) · JAMA · doi:10.1001/jama.295.11.1288 · Cited by 1,354
A COMPREHENSIVE PSYCHOPATHOLOGICAL RATING SCALE
Åsberg, M., Montgomery, S., Perris, C., Schalling, D., & Sedvall, G. (1978) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1978.tb02357.x · Cited by 1,327
Obesity and Vascular Risk Factors at Midlife and the Risk of Dementia and Alzheimer Disease
Kivipelto, M., Ngandu, T., Fratiglioni, L., Viitanen, M., Kåreholt, I., Winblad, B., Helkala, E.-L., Tuomilehto, J., Soininen, H., & Nissinen, A. (2005) · Archives of Neurology · doi:10.1001/archneur.62.10.1556 · Cited by 1,291

Show all 48 references

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Leo, E. E. M., Rojas-Herrera, R. A., & Campos, M. R. S. (2020) · Food Reviews International · doi:10.1080/87559129.2020.1762639 · Cited by 2
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Dominguez, L. J., & Barbagallo, M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815238-6.00015-8 · Cited by 2
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Wang, Y., Liu, J., Rong, Z., Dang, L., Ling, G., Shan, W., Shang, S., Wang, J., Jingyi, W., Qu, Q., et al. (2025) · Aging Clinical and Experimental Research · doi:10.1007/s40520-025-03143-z · Cited by 1
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Liang, P., Yang, L., Chen, Y., Cheng, Z., Gao, Y., Sui, C., Zhang, X., Wang, N., Wang, Y., Liang, C., et al. (2025) · Brain and Behavior · doi:10.1002/brb3.70862 · Cited by 1
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Brain function and glucocorticoids in obesity and type 2 diabetes including effects of lifestyle interventions
Stomby, A. (2015) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 1

Authors: Gustafson, D. R., Karlsson, C., Skoog, I., Rosengren, L., Lissner, L., & Blennow, K.
Affiliations: Medical College of Wisconsin (US)
University of Gothenburg (SE)
Corresponding author: Gustafson, D. R.
ORCID: Gustafson, D. R.
Karlsson, C.
Skoog, I.
Rosengren, L.
Lissner, L.
Blennow, K.
Venue: Journal of Internal Medicine
Publisher: Wiley
Published: 2007-11-15
Volume: 262
Issue: 6
Pages: 643-650
ISSN: 0954-6820 (ISSN-L)
1365-2796
DOI: 10.1111/j.1365-2796.2007.01869.x
OpenAlex: W1563616747
Cited by: 107
References: 48
Citations by year: 2026: 3 · 2025: 5 · 2024: 7 · 2023: 5 · 2022: 7 · 2021: 12 · 2020: 8 · 2019: 13 · 2018: 4 · 2017: 8 · 2016: 6 · 2015: 7 · 2014: 6 · 2013: 3 · 2012: 3
FWCI: 1.49
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Alzheimer's Association (ZEN‐01‐3151, IIRG‐00‐2159)
Forskningsrådet för Arbetsliv och Socialvetenskap (ZEN-01-3151, IIRG-00-2159)
Vetenskapsrådet (11267)
Swedish Brain Power (11267)
National Institutes of Health (1r03ag026098-01a1)
National Institute on Aging (1R03AG026098)
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords: blood-brain barrier integrity, CSF/serum albumin ratio, sex hormone-binding globulin, leptin, body mass index, obesity, overweight, women, aging, sex hormones, brain health
MeSH terms: Aged, Aged, 80 and over, Albumins, Blood-Brain Barrier, Female, Humans, Middle Aged, Obesity, Retrospective Studies, Serum Albumin, Sex Hormone-Binding Globulin, Biomarkers, Linear Models, Leptin, Overweight

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Mid‐life adiposity factors relate to blood–brain barrier integrity in late life

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