Cited by 194Smoking Behavior and CessationPneumonia and Respiratory InfectionsChronic Obstructive Pulmonary Disease (COPD) Research

Smoking and the outcome of infection: Review: Smoking and infection

Huttunen, R., Heikkinen, T., Syrjänen, J.·2011·Journal of Internal Medicine

Abstract

Abstract. Huttunen R, Heikkinen T, Syrjänen J. (Department of Internal Medicine, Tampere University Hospital, Tampere; Department of Pediatrics, Turku University Hospital, Turku; Finland) Smoking and the Outcome of Infection (Review). J Intern Med 2010; 269: 258–269. Smoking has substantial local and systemic adverse effects on the immune system, respiratory tract and skin and soft tissues. Smokers are at increased risk of invasive pneumococcal disease, pneumonia, periodontitis, surgical infections, tuberculosis, influenza and meningococcal disease. The results of several studies indicate that smokers with periodontitis or tuberculosis suffer more severe disease. Data on the impact of smoking on sepsis and pneumonia are controversial and limited, and systematic data regarding the outcome of the majority of infections in smokers are scarce. Abundant data indicate that children exposed to environmental tobacco smoke (ETS) suffer from more severe infections. However, information regarding the effects of ETS on the outcome of infections in adults is limited. Various aspects of the relation between smoking and the outcome of bacterial infection (e.g. potential dose-dependent effects and the interactions between smoking and other environmental factors that may affect the course of infectious diseases) remain to be established.

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Crossref · 10.1111/j.1365-2796.2010.02332.x

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Authors
Huttunen, R., Heikkinen, T., & Syrjänen, J.
Affiliations
  • Tampere University (FI)
  • Turku University Hospital (FI)
Corresponding author
Huttunen, R.
Venue
Journal of Internal Medicine
Publisher
Wiley
Published
2010-12-22
Volume
269
Issue
3
Pages
258-269
ISSN
0954-6820 (ISSN-L)
OpenAlex
W1524886294
Cited by
194
References
144
Citations by year
2026: 5 · 2025: 10 · 2024: 26 · 2023: 9 · 2022: 19 · 2021: 16 · 2020: 13 · 2019: 12 · 2018: 6 · 2017: 7 · 2016: 9 · 2015: 13 · 2014: 12 · 2013: 18 · 2012: 15
FWCI
1.15
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Keywords
smoking, infection outcomes, immune system, respiratory tract, skin and soft tissue infections, invasive pneumococcal disease, pneumonia, periodontitis, surgical site infection, tuberculosis, influenza, meningococcal disease, sepsis, environmental tobacco smoke, children, dose-dependent effects, bacterial infection
MeSH terms
Adult, Child, Disease Susceptibility, Humans, Infections, Prognosis, Respiratory Tract Infections, Risk Factors, Smoking, Tobacco Smoke Pollution

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