CoChat
Sign Up
Cited by 165

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Interleukin-1 type 1 receptor/Toll-like receptor signalling in epilepsy: the importance of IL-1beta and high-mobility group box 1: Symposium: Danger signals and cytokines in epilepsy

Maroso, M., Balosso, S., Ravizza, T., Liu, J., Bianchi, M. E., Vezzani, A.·2011·Journal of Internal Medicine
DOI 10.1111/j.1365-2796.2011.02431.x
Open this paper in CoChat — free account

Abstract

Inflammatory processes in brain tissue have been described in human epilepsy of various aetiologies and in experimental models of seizures. This, together with the anticonvulsant properties of anti-inflammatory therapies both in clinical and in experimental settings, highlights the important role of brain inflammation in the aetiopathogenesis of seizures. Preclinical investigations in experimental models using pharmacological and genetic tools have identified a significant contribution of interleukin-1 (IL-1) type 1 receptor/Toll-like receptor (IL-1R/TLR) signalling to seizure activity. This signalling can be activated by ligands associated with infections (pathogen-associated molecular patterns) or by endogenous molecules, such as proinflammatory cytokines (e.g. IL-1beta) or danger signals [damage-associated molecular patterns, e.g. high-mobility group box 1 (HMGB1)]. IL-1beta and HMGB1 are synthesized and released by astrocytes and microglia in the rodent brain during seizures. Notably, a rapid release of HMGB1 from neurons appears to be triggered by proconvulsant drugs even before seizure occurrence and is involved in their precipitation of seizures. The activation of IL-1R/TLR signalling mediates rapid post-translational changes in N-methyl-d-aspartate-gated ion channels in neurons. A long-term decrease in seizure threshold has also been observed, possibly mediated by transcriptional activation of genes contributing to molecular and cellular plasticity. This emerging evid…

Overview

Integrity signals

Registry

Crossref · 10.1111/j.1365-2796.2011.02431.x

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 4 references

Research works printed but not linked: 48

  1. Pitkanen, 2002, Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy, Lancet Neurol, 1, 173, 10.1016/S1474-4422(02)00073-X · DOI
  2. Perucca, 2007, Development of new antiepileptic drugs: challenges, incentives, and recent advances, Lancet Neurol, 6, 793, 10.1016/S1474-4422(07)70215-6 · DOI
  3. Pitkanen, 2010, Therapeutic approaches to epileptogenesis - hope on the horizon, Epilepsia, 51, 2, 10.1111/j.1528-1167.2010.02602.x · DOI
  4. Vezzani, 2011, The role of inflammation in epilepsy, Nat Rev Neurol, 7, 31, 10.1038/nrneurol.2010.178 · DOI · Paper page
  5. Iyer, 2010, Evaluation of the innate and adaptive immunity in type I and type II focal cortical dysplasias, Epilepsia, 51, 1763, 10.1111/j.1528-1167.2010.02547.x · DOI
  6. Ravizza, 2010, Epilepsy Mechanisms, Models, and Translational Perspectives, 45, 10.1201/EBK1420085594-c4 · DOI
  7. Riazi, 2010, Contributions of peripheral inflammation to seizure susceptibility: cytokines and brain excitability, Epilepsy Res, 89, 34, 10.1016/j.eplepsyres.2009.09.004 · DOI
  8. Singh, 2008, Central nervous system infections and epilepsy, Epilepsia, 49, 1, 10.1111/j.1528-1167.2008.01748.x · DOI
  9. Bartfai, 2007, Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma, Ann N Y Acad Sci, 1113, 173, 10.1196/annals.1391.022 · DOI
  10. Ravizza, 2008, Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy, Neurobiol Dis, 29, 142, 10.1016/j.nbd.2007.08.012 · DOI
  11. Marcon, 2009, Age-dependent vascular changes induced by status epilepticus in rat forebrain: implications for epileptogenesis, Neurobiol Dis, 34, 121, 10.1016/j.nbd.2008.12.018 · DOI
  12. Shlosberg, 2010, Blood-brain barrier breakdown as a therapeutic target in traumatic brain injury, Nat Rev Neurol, 6, 393, 10.1038/nrneurol.2010.74 · DOI · Paper page
  13. Oby, 2006, The blood-brain barrier and epilepsy, Epilepsia, 47, 1761, 10.1111/j.1528-1167.2006.00817.x · DOI
  14. Ravizza, 2006, Status epilepticus induces time-dependent neuronal and astrocytic expression of interleukin-1 receptor type I in the rat limbic system, Neuroscience, 137, 301, 10.1016/j.neuroscience.2005.07.063 · DOI
  15. Ravizza, 2006, The IL-1beta system in epilepsy-associated malformations of cortical development, Neurobiol Dis, 24, 128, 10.1016/j.nbd.2006.06.003 · DOI · Paper page
  16. Boer, 2008, Inflammatory processes in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex, Epilepsy Res, 78, 7, 10.1016/j.eplepsyres.2007.10.002 · DOI
  17. Maroso, 2010, Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures, Nat Med, 16, 413, 10.1038/nm.2127 · DOI · Paper page
  18. Zurolo, 2011, Activation of TLR, RAGE and HMGB1 signaling in malformation of cortical development, Brain, 134, 1015, 10.1093/brain/awr032 · DOI · Paper page
  19. Vezzani, 1999, Interleukin-1beta immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: functional evidence for enhancement of electrographic seizures, J Neurosci, 19, 5054, 10.1523/JNEUROSCI.19-12-05054.1999 · DOI
  20. Vezzani, 2000, Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice, Proc Natl Acad Sci U S A, 97, 11534, 10.1073/pnas.190206797 · DOI
  21. Marchi, 2009, Antagonism of peripheral inflammation reduces the severity of status epilepticus, Neurobiol Dis, 33, 171, 10.1016/j.nbd.2008.10.002 · DOI
  22. Auvin, 2010, Inflammation enhances epileptogenesis in the developing rat brain, Neurobiol Dis, 40, 303, 10.1016/j.nbd.2010.06.004 · DOI
  23. Ravizza, 2006, Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategy, Epilepsia, 47, 1160, 10.1111/j.1528-1167.2006.00590.x · DOI
  24. Maroso, 2011, ICE/Caspase 1 inhibition reduces acute seizures and drug resistant chronic epileptic activity in mice, Neurotherapeutics, 8, 304, 10.1007/s13311-011-0039-z · DOI
  25. Henshall, 2000, Alterations in bcl-2 and caspase gene family protein expression in human temporal lobe epilepsy, Neurology, 55, 250, 10.1212/WNL.55.2.250 · DOI
  26. Ravizza, 2008, Interleukin Converting Enzyme inhibition impairs kindling epileptogenesis in rats by blocking astrocytic IL-1beta production, Neurobiol Dis, 31, 327, 10.1016/j.nbd.2008.05.007 · DOI
  27. van de Veerdonk, 2011, Inflammasome activation and IL-1beta and IL-18 processing during infection, Trends Immunol, 32, 110, 10.1016/j.it.2011.01.003 · DOI
  28. Rodgers, 2009, The cortical innate immune response increases local neuronal excitability leading to seizures, Brain, 132, 2478, 10.1093/brain/awp177 · DOI
  29. Huttunen, 2004, Amphoterin as an extracellular regulator of cell motility: from discovery to disease, J Intern Med, 255, 351, 10.1111/j.1365-2796.2003.01301.x · DOI
  30. Pedrazzi, 2007, Selective proinflammatory activation of astrocytes by high-mobility group box 1 protein signaling, J Immunol, 179, 8525, 10.4049/jimmunol.179.12.8525 · DOI
  31. Sha, 2008, HMGB1 develops enhanced proinflammatory activity by binding to cytokines, J Immunol, 180, 2531, 10.4049/jimmunol.180.4.2531 · DOI
  32. Garcia-Arnandis, 2010, High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1beta in osteoarthritic synoviocytes, Arthritis Res Ther, 12, R165, 10.1186/ar3124 · DOI
  33. Wang, 2000, Interleukin-1beta inhibits gamma-aminobutyric acid type A (GABA(A)) receptor current in cultured hippocampal neurons, J Pharmacol Exp Ther, 292, 497, 10.1016/S0022-3565(24)35318-2 · DOI · Paper page
  34. Zeise, 1997, Interleukin-1beta does not increase synaptic inhibition in hippocampal CA3 pyramidal and dentate gyrus granule cells of the rat in vitro, Brain Res, 768, 341, 10.1016/S0006-8993(97)00787-7 · DOI
  35. Zhang, 2008, Inhibition of NMDA-induced outward currents by interleukin-1beta in hippocampal neurons, Biochem Biophys Res Commun, 372, 816, 10.1016/j.bbrc.2008.05.128 · DOI
  36. Viviani, 2003, Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases, J Neurosci, 23, 8692, 10.1523/JNEUROSCI.23-25-08692.2003 · DOI · Paper page
  37. Tabarean, 2006, Interleukin-1beta induces hyperpolarization and modulates synaptic inhibition in preoptic and anterior hypothalamic neurons, Neuroscience, 141, 1685, 10.1016/j.neuroscience.2006.05.007 · DOI
  38. Davis, 2006, IL-1beta induces a MyD88-dependent and ceramide-mediated activation of Src in anterior hypothalamic neurons, J Neurochem, 98, 1379, 10.1111/j.1471-4159.2006.03951.x · DOI
  39. Balosso, 2008, A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1beta, Brain, 131, 3256, 10.1093/brain/awn271 · DOI
  40. Meador, 2007, The basic science of memory as it applies to epilepsy, Epilepsia, 48, 23, 10.1111/j.1528-1167.2007.01396.x · DOI
  41. Vezzani, 2010, ICE/caspase 1 inhibitors and IL-1beta receptor antagonists as potential therapeutics in epilepsy, Curr Opin Investig Drugs, 11, 43
  42. Seiffert, 2004, Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex, J Neurosci, 24, 7829, 10.1523/JNEUROSCI.1751-04.2004 · DOI
  43. David, 2009, Astrocytic dysfunction in epileptogenesis: consequence of altered potassium and glutamate homeostasis?, J Neurosci, 29, 10588, 10.1523/JNEUROSCI.2323-09.2009 · DOI
  44. Eriksson, 2000, Increased expression of mRNA encoding interleukin-1beta and caspase-1, and the secreted isoform of interleukin-1 receptor antagonist in the rat brain following systemic kainic acid administration, J Neurosci Res, 60, 266, 10.1002/(SICI)1097-4547(20000415)60:2<266::AID-JNR16>3.0.CO;2-P · DOI
  45. De Simoni, 2000, Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus, Eur J Neurosci, 12, 2623, 10.1046/j.1460-9568.2000.00140.x · DOI
  46. Leon, 2008, Discovery and development of toll-like receptor 4 (TLR4) antagonists: a new paradigm for treating sepsis and other diseases, Pharm Res, 25, 1751, 10.1007/s11095-008-9571-x · DOI
  47. Vezzani, 2008, The role of cytokines in the pathophysiology of epilepsy, Brain Behav Immun, 22, 797, 10.1016/j.bbi.2008.03.009 · DOI
  48. Akin, 2011, IL-1β is induced in reactive astrocytes in the somatosensory cortex of rats with genetic absence epilepsy at the onset of spike-and-wave discharges, and contributes to their occurrence, Neurobiol Dis., 10.1016/j.nbd.2011.05.015 · DOI

Cited by

Sorted by citations

Metadata

Authors
Maroso, M., Balosso, S., Ravizza, T., Liu, J., Bianchi, M. E., & Vezzani, A.
Venue
Journal of Internal Medicine
Publisher
Wiley
Published
2011-09-19
Volume
270
Issue
4
Pages
319-326
ISSN
0954-6820
DOI
10.1111/j.1365-2796.2011.02431.x
Cited by
165
References
4
Language
en
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 1443 d)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review