The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
The Neuroendocrinology of Stress: A Never Ending Story
Abstract
Evolutionary success depends on our ability to adapt to changing circumstances. The neuroendocrine response to stress is an excellent example of a plastic system that responds to threats to homeostasis and alters its output to meet current and expected future demands. At the level of the hypothalamus, the corticotroph secretagogues corticotrophin‐releasing hormone (CRH) and arginine vasopressin (AVP) respond rapidly to an acute stressor but, following chronic stress, they adapt with a reduction of CRH but a major increase in AVP. The release of CRH and AVP activates pro‐opiomelanocortin in anterior pituitary corticotroph cells and the release of adrenocorticotrophic hormone into peripheral blood from where it targets receptors in the adrenal cortex to release glucocorticoid hormones. These hormones (i.e. corticosterone in the rat and cortisol in man) are released in a pulsatile ultradian pattern which defines the normal circadian rhythm. The frequency of the pulses is increased under states of chronic stress, and in rats with genetically determined hyper‐responsiveness of the hypothalamic‐pituitary‐adrenal axis. Interestingly, neonatal influences can also programme alterations in ultradian rhythmicity, implicating epigenetic factors in its regulation. At the level of tissue receptors, the alteration in pattern of glucocorticoid ultradian rhythm has differential effects on mineralocorticoid receptor and glucocorticoid receptor (GR) binding to DNA and offers a mechanism for tissue specific responses to altered glucocorticoid dynamics. The effects of neonatal experience are not only seen at the level of CRH and GR regulation, but also are evident in behavioural responses to stress and in the responsiveness of brain stem serotonergic pathways, as measured by tryptophan hydroxylase mRNA in the brain stem.
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Garber, C. E., Blissmer, B., Deschenes, M. R., Franklin, B. A., Lamonte, M. J., Lee, I.-M., Nieman, D. C., & Swain, D. P. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318213fefb · Cited by 9,319
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880
Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation
REUL, J. M. H. M., & KLOET, E. R. D. (1985) · Endocrinology · doi:10.1210/endo-117-6-2505 · Cited by 2,580
An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus
Pereira, A. C., Huddleston, D. E., Brickman, A. M., Sosunov, A. A., Hen, R., McKhann, G. M., Sloan, R., Gage, F. H., Brown, T. R., & Small, S. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611721104 · Cited by 1,353
Exercise and Pharmacotherapy in the Treatment of Major Depressive Disorder
Blumenthal, J. A., Babyak, M. A., Doraiswamy, P. M., Watkins, L., Hoffman, B. M., Barbour, K. A., Herman, S., Craighead, W. E., Brosse, A. L., Waugh, R., et al. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318148c19a · Cited by 1,019
Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence
Hamer, M., & Chida, Y. (2009) · Psychological Medicine · doi:10.1017/s0033291708003681 · Cited by 988
Cognitive stimulation to improve cognitive functioning in people with dementia
Woods, B., Aguirre, E., Spector, A. E., & Orrell, M. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005562.pub2 · Cited by 855
The effect of acute aerobic exercise on positive activated affect: A meta-analysis
Reed, J., & Ones, D. S. (2006) · Psychology of Sport and Exercise · doi:10.1016/j.psychsport.2005.11.003 · Cited by 622
Pleasure and displeasure from the body: perspectives from exercise
Ekkekakis, P. (2003) · Cognition and Emotion · doi:10.1080/02699930302292 · Cited by 619
Bartlett, J. D., Close, G. L., MacLaren, D. P. M., Gregson, W., Drust, B., & Morton, J. P. (2011) · Journal of Sports Sciences · doi:10.1080/02640414.2010.545427 · Cited by 593
Research works printed but not linked: 18
- 10.1016/j.yfrne.2003.07.001 · DOI · Paper page
- 10.1073/pnas.86.23.9569 · DOI · Paper page
- 10.1113/jphysiol.1988.sp017261 · DOI
- 10.1038/328643a0 · DOI
- 10.1210/en.130.3.1394 · DOI
- 10.1111/j.1476-5381.1995.tb15089.x · DOI
- 10.1210/endo.138.10.5446 · DOI
- 10.1111/j.1469-7793.1998.605bk.x · DOI
- 10.1210/endo-123-1-396 · DOI
- 10.1677/joe.0.1110027 · DOI
- 10.1210/endo.139.2.5721 · DOI · Paper page
- 10.1046/j.1365-2826.2001.00715.x · DOI
- 10.1073/pnas.86.12.4771 · DOI · Paper page
- 10.1126/science.156.3772.258 · DOI · Paper page
- 10.1210/en.2004-1201 · DOI
- 10.1113/jphysiol.2004.078212 · DOI
- Gardner KL, 2006, Early Life Experience Programs Gene Expression in Serotonin Neurons
- John S, 2008, Molecular Cell, 611
Cited by
Items 301–306 of 306
Galvão, M. C., Chaves-Kirsten, G. P., Queiroz-Hazarbassanov, N., Carvalho, V. M., Bernardi, M. M., & Kirsten, T. B. (2015) · Life Sciences · doi:10.1016/j.lfs.2014.10.019 · Cited by 17
Mindfulness Induces Changes in Anterior Alpha Asymmetry in Healthy Older Adults
Isbel, B., Lagopoulos, J., Hermens, D. F., & Summers, M. J. (2019) · Mindfulness · doi:10.1007/s12671-019-01106-w · Cited by 15
Bian, X., Wang, Q., Wang, Y., & Lou, S. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1305208 · Cited by 15
Millon, E. M., Lehrer, P. M., & Shors, T. J. (2022) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-021-09530-2 · Cited by 11
Tharwat, D., Trousselard, M., Fromage, D., Belrose, C., Balès, M., Sutter-Dallay, A.-L., Ezto, M.-L., Hurstel, F., Harvey, T., Martin, S., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19031545 · Cited by 3
Kinsman, L. M., Norrie, H. J., Rachor, G. S., & Asmundson, G. J. G. (2024) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2024_500 · Cited by 2
Metadata
- Authors
- Lightman, S. L.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2008-06
- Volume
- 20
- Issue
- 6
- Pages
- 880-884
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W2159202946
- Cited by
- 3,566
- References
- 24
- FWCI
- 24.72
- Type
- journal article
- Language
- en
- Open access
- closed
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