Slow oscillations in human non-rapid eye movement sleep electroencephalogram: effects of increased sleep pressure
Open accessAbstract
Slow oscillations (< 1 Hz) in the non-rapid eye movement (NREM) sleep electroencephalogram (EEG) result from slow membrane potential fluctuations of cortical neurones, alternating between a depolarized up-state and a hyperpolarized down-state. They are thought to underlie the restorative function of sleep. We investigated the behaviour of slow oscillations in humans under increased sleep pressure to assess their contribution to sleep homeostasis. EEG recordings (C3A2) of baseline and recovery sleep after sleep deprivation (eight healthy males, mean age 23 years; 40 h of prolonged wakefulness) were analysed. Half-waves were defined as positive or negative deflections between consecutive zero crossings in the 0.5-2 Hz range of the band-pass filtered EEG. Increased sleep pressure resulted in a redistribution of half-waves between 0.5 and 2 Hz: the number of half-waves per minute was reduced below 0.9 Hz while it was increased above 1.2 Hz. EEG power was increased above 1 Hz. The increase in frequency was accompanied by increased slope of the half-waves and decreased number of multi-peak waves. In both baseline and recovery sleep, amplitude and slope were correlated highly over a broad frequency range and positive half-waves were characterized by a lower frequency than the negative ones, pointing to a longer duration of up- than down-states. We hypothesize that the higher frequency of slow oscillatory activity after prolonged wakefulness may relate to faster alternations between…
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The decrease in slope possibly reflects a decrease in the synchrony and speed of recruitment of neurons at the down-to-up state transition.
“possibly reflecting a decrease in the synchrony and speed of recruitment of neurons at the down-to-up state transition (87,360,994,1267).”
From About Sleep's Role in Memory (2013) · cites this paper as [87]
The slope of the slow waves decreases from early to late sleep.
“Independent of the decrease in amplitude, the slope of the slow waves also decreases from early to late sleep”
From About Sleep's Role in Memory (2013) · cites this paper as [87]
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“Independent of the decrease in amplitude, the slope of the slow waves also decreases from early to late sleep, possibly reflecting a decrease in the synchrony and speed of recruitment of neurons at the down-to-up state transition (87, 360, 994, 1267).”
BackgroundSleep homeostasis in the rat is preserved during chronic sleep restriction
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Ultra-Slow delta power in chronic fatigue syndrome
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- Authors
- BERSAGLIERE, A., & ACHERMANN, P.
- Affiliations
- University of Zurich (CH)
- Corresponding author
- ACHERMANN, PETER
- ORCID
- ACHERMANN, PETER
- Venue
- Journal of Sleep Research
- Publisher
- Wiley
- Published
- 2010-03
- Volume
- 19
- Issue
- 1p2
- Pages
- 228-237
- ISSN
- 0962-1105 (ISSN-L)
- 1365-2869
- OpenAlex
- W2002592783
- Cited by
- 102
- References
- 8
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 11 · 2023: 2 · 2022: 7 · 2021: 4 · 2020: 10 · 2019: 6 · 2018: 5 · 2017: 6 · 2016: 3 · 2015: 5 · 2014: 7 · 2013: 8 · 2012: 8
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Journal of Sleep Research (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- slow oscillations, NREM sleep, sleep pressure, sleep homeostasis, sleep deprivation, recovery sleep, slow-wave activity, EEG spectral power
- MeSH terms
- Electroencephalography, Homeostasis, Humans, Male, Sleep, Sleep Stages, Young Adult
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