Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep
Abstract
Plastic changes occurring during wakefulness aid in the acquisition and consolidation of memories. For some memories, further consolidation requires sleep, but whether plastic processes during wakefulness and sleep differ is unclear. We show that, in rat cortex and hippocampus, GluR1-containing AMPA receptor (AMPAR) levels are high during wakefulness and low during sleep, and changes in the phosphorylation states of AMPARs, CamKII and GSK3beta are consistent with synaptic potentiation during wakefulness and depression during sleep. Furthermore, slope and amplitude of cortical evoked responses increase after wakefulness, decrease after sleep and correlate with changes in slow-wave activity, a marker of sleep pressure. Changes in molecular and electrophysiological indicators of synaptic strength are largely independent of the time of day. Finally, cortical long-term potentiation can be easily induced after sleep, but not after wakefulness. Thus, wakefulness appears to be associated with net synaptic potentiation, whereas sleep may favor global synaptic depression, thereby preserving an overall balance of synaptic strength.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Levels of postsynaptic glutamatergic AMPA receptors containing the glutamate receptor (GluR1)-1 subunit reliably indicate synaptic plasticity and were revealed to be high during wakefulness and distinctly lower (by 40%) during sleep.
“Levels of postsynaptic glutamatergic AMPA receptors containing the glutamate receptor (GluR1)-1 subunit reliably indicate synaptic plasticity and were revealed to be high during wakefulness and distinctly lower (by 40%) during sleep (1264).”
From About Sleep's Role in Memory (2013) · cites this paper as [1264]
In rats, slope and amplitude of the electrically evoked cortical potential increased during sustained wakefulness and decreased after sleep, and these changes correlated with SWA.
“Indeed, in rats, slope and amplitude of the electrically evoked cortical potential as indicators of synaptic strength progressively increased during sustained wakefulness and decreased after sleep, and these changes were correlated with SWA (1264).”
From About Sleep's Role in Memory (2013) · cites this paper as [1264]
Prolonged waking decreases the ability to induce further long-term potentiation in various models, which in turn should inhibit learning.
“Prolonged waking decreases the ability to induce further LTP in various models, which in turn should inhibit learning (Vyazovskiy et al., 2008);”
From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Vyazovskiy et al., 2008
Cites
Bliss, T. V. P., & Gardner-Medwin, A. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010274 · Cited by 7,460 · see citing works
Principles and Practice of Sleep Medicine
Kryger, M. H., Roth, T. G., & Dement, W. C. (2011) · Elsevier eBooks · doi:10.1016/c2009-0-59875-3 · Cited by 5,118 · see citing works
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968 · see citing works
An Energy Budget for Signaling in the Grey Matter of the Brain
Attwell, D., & Laughlin, S. B. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200110000-00001 · Cited by 3,543 · see citing works
Sleep function and synaptic homeostasis
Tononi, G., & Cirelli, C. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.05.002 · Cited by 2,151 · see citing works
Learning induces long-term potentiation in the hippocampus
Whitlock, J. R., Heynen, A. J., Shuler, M. G., & Bear, M. F. (2006) · Science · doi:10.1126/science.1128134 · Cited by 1,913 · see citing works
The molecular basis of CaMKII function in synaptic and behavioural memory
Lisman, J., Schulman, H., & Cline, H. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn753 · Cited by 1,860 · see citing works
Huber, R., Felice Ghilardi, M., Massimini, M., & Tononi, G. (2004) · Nature · doi:10.1038/nature02663 · Cited by 1,854 · see citing works
Self-citationSleep Homeostasis and Models of Sleep Regulation
Borb, A. A., & Achermann, P. (1999) · Journal of Biological Rhythms · doi:10.1177/074873099129000894 · Cited by 1,503 · see citing works
Grouping of brain rhythms in corticothalamic systems
Steriade, M. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.10.029 · Cited by 1,296 · see citing works
Brainstem Control of Wakefulness and Sleep
Steriade, M., & McCarley, R. W. (1990) · doi:10.1007/978-1-4757-4669-3 · Cited by 1,188 · see citing works
Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity
Lee, H.-K., Barbarosie, M., Kameyama, K., Bear, M. F., & Huganir, R. L. (2000) · Nature · doi:10.1038/35016089 · Cited by 1,116 · see citing works
Receptor trafficking and synaptic plasticity
Collingridge, G. L., Isaac, J. T. R., & Wang, Y. T. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1556 · Cited by 1,046 · see citing works
Learning-Induced LTP in Neocortex
Rioult-Pedotti, M.-S., Friedman, D. J., & Donoghue, J. P. (2000) · Science · doi:10.1126/science.290.5491.533 · Cited by 1,014 · see citing works
Rall, W. (1967) · Journal of Neurophysiology · doi:10.1152/jn.1967.30.5.1138 · Cited by 996 · see citing works
Postsynaptic receptor trafficking underlying a form of associative learning
Rumpel, S., LeDoux, J., Zador, A., & Malinow, R. (2005) · Science · doi:10.1126/science.1103944 · Cited by 775 · see citing works
LTP Inhibits LTD in the Hippocampus via Regulation of GSK3β
Peineau, S., Taghibiglou, C., Bradley, C. A., Wong, T. P., Liu, L., Lu, J., Lo, E., Wu, D., Saule, E., Bouschet, T., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.029 · Cited by 690 · see citing works
Arm immobilization causes cortical plastic changes and locally decreases sleep slow wave activity
Huber, R., Ghilardi, M. F., Massimini, M., Ferrarelli, F., Riedner, B. A., Peterson, M. J., & Tononi, G. (2006) · Nature Neuroscience · doi:10.1038/nn1758 · Cited by 579 · see citing works
Born, J., Rasch, B., & Gais, S. (2006) · The Neuroscientist · doi:10.1177/1073858406292647 · Cited by 557 · see citing works
Plant, K., Pelkey, K. A., Bortolotto, Z. A., Morita, D., Terashima, A., McBain, C. J., Collingridge, G. L., & Isaac, J. T. R. (2006) · Nature Neuroscience · doi:10.1038/nn1678 · Cited by 542 · see citing works
Isomura, Y., Sirota, A., Özen, S., Montgomery, S., Mizuseki, K., Henze, D. A., & Buzsáki, G. (2006) · Neuron · doi:10.1016/j.neuron.2006.10.023 · Cited by 500 · see citing works
Emotion Enhances Learning via Norepinephrine Regulation of AMPA-Receptor Trafficking
Hu, H., Real, E., Takamiya, K., Kang, M.-G., Ledoux, J., Huganir, R. L., & Malinow, R. (2007) · Cell · doi:10.1016/j.cell.2007.09.017 · Cited by 496 · see citing works
Kim, M. J., Dunah, A. W., Wang, Y. T., & Sheng, M. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.031 · Cited by 494 · see citing works
Why do we sleep?11Published on the World Wide Web on 7 November 2000.
Sejnowski, T. J., & Destexhe, A. (2000) · Brain Research · doi:10.1016/s0006-8993(00)03007-9 · Cited by 489 · see citing works
Riedner, B. A., Vyazovskiy, V. V., Huber, R., Massimini, M., Esser, S., Murphy, M., & Tononi, G. (2007) · Sleep · doi:10.1093/sleep/30.12.1643 · Cited by 424 · see citing works
Expression Mechanisms Underlying NMDA Receptor‐Dependent Long‐Term Potentiation
Nicoll, R., & Malenka, R. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11320.x · Cited by 417 · see citing works
McDermott, C. M., LaHoste, G. J., Chen, C., Musto, A., Bazan, N. G., & Magee, J. C. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-29-09687.2003 · Cited by 407 · see citing works
Neuronal activity during the sleep-waking cycle
Steriade, M., & Hobson, J. A. (1976) · Progress in Neurobiology · doi:10.1016/0301-0082(76)90013-7 · Cited by 386 · see citing works
The sequential hypothesis of the function of sleep
Giuditta, A., Ambrosini, M. V., Montagnese, P., Mandile, P., Cotugno, M., Zucconi, G. G., & Vescia, S. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00012-i · Cited by 382 · see citing works
Cirelli, C., & Tononi, G. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09187.2000 · Cited by 369 · see citing works
Conservation of total synaptic weight through balanced synaptic depression and potentiation
Royer, S., & Paré, D. (2003) · Nature · doi:10.1038/nature01530 · Cited by 357 · see citing works
Hippocampal Sharp Wave-Ripples Linked to Slow Oscillations in Rat Slow-Wave Sleep
Mölle, M., Yeshenko, O., Marshall, L., Sara, S. J., & Born, J. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00014.2006 · Cited by 337 · see citing works
Esser, S. K., Hill, S. L., & Tononi, G. (2007) · Sleep · doi:10.1093/sleep/30.12.1617 · Cited by 315 · see citing works
Distinct roles for spontaneous and visual activity in remodeling of the retinogeniculate synapse
Hooks, B. M., & Chen, C. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.007 · Cited by 311 · see citing works
Molecular mechanism for loss of visual cortical responsiveness following brief monocular deprivation
Heynen, A. J., Yoon, B.-J., Liu, C.-H., Chung, H. J., Huganir, R. L., & Bear, M. F. (2003) · Nature Neuroscience · doi:10.1038/nn1100 · Cited by 305 · see citing works
Association Between Brain Temperature and Dentate Field Potentials in Exploring and Swimming Rats
Moser, E. I., Mathiesen, I., & Andersen, P. N. (1993) · Science · doi:10.1126/science.8446900 · Cited by 272 · see citing works
Heynen, A., Quinlan, E., Bae, D. C., & Bear, M. (2000) · Neuron · doi:10.1016/s0896-6273(00)00130-6 · Cited by 237 · see citing works
Vyazovskiy, V. V., Riedner, B. A., Cirelli, C., & Tononi, G. (2007) · SLEEP · doi:10.1093/sleep/30.12.1631 · Cited by 225 · see citing works
Long-Term Potentiation of Thalamocortical Transmission in the Adult Visual CortexIn Vivo
Heynen, A. J., & Bear, M. F. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-24-09801.2001 · Cited by 220 · see citing works
Brain Control of Wakefulness and Sleep
Steriade, M. 1.-2., & McCarley, R. W. (2005) · Springer eBooks · doi:10.1007/b102230 · Cited by 219 · see citing works
Pathway-Specific Trafficking of Native AMPARs by In Vivo Experience
Clem, R. L., & Barth, A. L. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.019 · Cited by 217 · see citing works
Cross-modal regulation of synaptic AMPA receptors in primary sensory cortices by visual experience
Goel, A., Jiang, B., Xu, L. W., Song, L., Kirkwood, A., & Lee, H.-K. (2006) · Nature Neuroscience · doi:10.1038/nn1725 · Cited by 210 · see citing works
Tartar, J. L., Ward, C. P., McKenna, J. T., Thakkar, M., Arrigoni, E., McCarley, R. W., Brown, R. E., & Strecker, R. E. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04808.x · Cited by 206 · see citing works
Insufficient Sleep Reversibly Alters Bidirectional Synaptic Plasticity and NMDA Receptor Function
Kopp, C., Longordo, F., Nicholson, J. R., & Lüthi, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2702-06.2006 · Cited by 192 · see citing works
Fox, C. J., Russell, K., Wang, Y. T., & Christie, B. R. (2006) · Hippocampus · doi:10.1002/hipo.20230 · Cited by 172 · see citing works
Sleep Deprivation Impairs Long-Term Potentiation in Rat Hippocampal Slices
Campbell, I. G., Guinan, M. J., & Horowitz, J. M. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.88.2.1073 · Cited by 169 · see citing works
Sleep Homeostasis and Models of Sleep Regulation
Borbély, A. A., & Achermann, P. (2005) · Elsevier eBooks · doi:10.1016/b0-72-160797-7/50040-9 · Cited by 104 · see citing works
Cellular mechanisms of burst firing‐mediated long‐term depression in rat neocortical pyramidal cells
Czarnecki, A., Birtoli, B., & Ulrich, D. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.123588 · Cited by 99 · see citing works
Acoustically evoked potentials in the rat during sleep and waking
Hall, R. D., & Borbély, A. A. (1970) · Experimental Brain Research · doi:10.1007/bf00234203 · Cited by 87 · see citing works
Racine, R. J., Chapman, C. A., Trepel, C., Teskey, G. C., & Milgram, N. W. (1995) · Brain Research · doi:10.1016/0006-8993(95)01025-0 · Cited by 81 · see citing works
Long-term potentiation in vivo in layers II/III of rat barrel cortex
Glazewski, S., Herman, C. C., McKenna, M. A., Chapman, P. F., & Fox, K. D. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00039-2 · Cited by 52 · see citing works
LTP: AMPA receptors trading places
Kauer, J. A., & Malenka, R. C. (2006) · Nature Neuroscience · doi:10.1038/nn0506-593 · Cited by 26 · see citing works
Cain, D. P., Hargreaves, E. L., & Boon, F. H. (1994) · Brain Research · doi:10.1016/s0006-8993(09)90019-1 · Cited by 16 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Diekelmann, S., & Born, J. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2762 · Cited by 3,760 · see citing works
Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783 · see citing works
Tononi, G., & Cirelli, C. (2014) · Neuron · doi:10.1016/j.neuron.2013.12.025 · Cited by 2,356 · see citing works
“, 2009) but did so in REM sleep as a function of REM theta power and not, as they do in cortex, in NREM sleep as a function of SWA (Vyazovskiy et al., 2009).”
BackgroundResultInfluentialSelf-citationHippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning
Buzsáki, G. (2015) · Hippocampus · doi:10.1002/hipo.22488 · Cited by 1,759 · see citing works
“A second complication is that firing rate distributions after waking experience shift to the right (Vyazovskiy et al., 2008; Kudrimoti et al., 1999; Grosmark et al., 2012).”
BackgroundInfluentialSynaptic Energy Use and Supply
Harris, J. J., Jolivet, R., & Attwell, D. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.019 · Cited by 1,747 · see citing works
“…to sleep), GluR1 subunits of AMPA receptors are present at a higher level and in a more phosphorylated state (consistent with an increased synaptic strength), synaptic currents and spine numbers increase, and evoked neuronal responses are larger (Vyazovskiy et al., 2008; Maret et al., 2011).”
Neurophysiological and Computational Principles of Cortical Rhythms in Cognition
Wang, X.-J. (2010) · Physiological Reviews · doi:10.1152/physrev.00035.2008 · Cited by 1,939 · see citing works
“In fact, there is evidence that excitatory synaptic connections in the cortex are overall depressed in sleep and potentiated in wakefulness (1019), suggesting that a primary function of slow-wave sleep is homeostatic regulation of synaptic circuitry (283, 655, 959).”
BackgroundThe hyperarousal model of insomnia: A review of the concept and its evidence
Riemann, D., Spiegelhalder, K., Feige, B., Voderholzer, U., Berger, M., Perlis, M., & Nissen, C. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.04.002 · Cited by 1,789 · see citing works
Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle
Kang, J.-E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. (2009) · Science · doi:10.1126/science.1180962 · Cited by 1,565 · see citing works
Mechanisms of systems memory consolidation during sleep
Klinzing, J. G., Niethard, N., & Born, J. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0467-3 · Cited by 1,176 · see citing works
Glymphatic failure as a final common pathway to dementia
Nedergaard, M., & Goldman, S. A. (2020) · Science · doi:10.1126/science.abb8739 · Cited by 1,145 · see citing works
Neuronal activity regulates the regional vulnerability to amyloid-β deposition
Bero, A. W., Yan, P., Roh, J. H., Cirrito, J. R., Stewart, F. R., Raichle, M. E., Lee, J.-M., & Holtzman, D. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2801 · Cited by 880 · see citing works
“Previous data from humans and animal models suggest that periods of wakefulness are associated with increased synaptic strength and periods of sleep are associated with decreased synaptic strengt”
BackgroundSynaptic AMPA receptor plasticity and behavior
Kessels, H. W., & Malinow, R. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.015 · Cited by 993 · see citing works
Integrated Brain Circuits: Astrocytic Networks Modulate Neuronal Activity and Behavior
Halassa, M. M., & Haydon, P. G. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135843 · Cited by 835 · see citing works
The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans
Holth, J. K., Fritschi, S. K., Wang, C., Pedersen, N. P., Cirrito, J. R., Mahan, T. E., Finn, M. B., Manis, M., Geerling, J. C., Fuller, P. M., et al. (2019) · Science · doi:10.1126/science.aav2546 · Cited by 813 · see citing works
“As neuronal synaptic strength/connectivity is higher during wakefulness than during sleep (11, 12), we asked whether tau levels in the brain interstitial fluid (ISF) varied with the sleep-wake cycle.”
BackgroundRegional aerobic glycolysis in the human brain
Vaishnavi, S. N., Vlassenko, A. G., Rundle, M. M., Snyder, A. Z., Mintun, M. A., & Raichle, M. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010459107 · Cited by 738 · see citing works
“Together these two studies provide a tentative link between the metabolism of learning-induced biosynthesis and a hypothesis that associates wakefulness with synaptic potentiation and sleep with synaptic renormalization (55, 56), a process that has been associated with changes in brain glucose consumption in laborator…”
BackgroundCortical firing and sleep homeostasis
Vyazovskiy, V. V., Olcese, U., Lazimy, Y. M., Faraguna, U., Esser, S. K., Williams, J. C., Cirelli, C., & Tononi, G. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.024 · Cited by 740 · see citing works
“Another possibility is that changes in neuronal firing and synchrony reflect a progressive, net increase in the strength of cortico-cortical connections during wakefulness, followed by a gradual net decrease during sleep (Tononi and Cirelli, 2006), as suggested by some recent studies (Bellina et al., 2008; Gilestro et…”
BackgroundResultNeuromodulation of Brain States
Lee, S., & Dan, Y. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.012 · Cited by 666 · see citing works
“At the synaptic level, some studies found net synaptic strengthening during wakefulness and depression during sleep (Vyazovskiy et al., 2008).”
Sleep promotes branch-specific formation of dendritic spines after learning
Yang, G., Lai, C. S. W., Cichon, J., Ma, L., Li, W., & Gan, W.-B. (2014) · Science · doi:10.1126/science.1249098 · Cited by 616 · see citing works
Ultrastructural evidence for synaptic scaling across the wake/sleep cycle
de Vivo, L., Bellesi, M., Marshall, W., Bushong, E. A., Ellisman, M. H., Tononi, G., & Cirelli, C. (2017) · Science · doi:10.1126/science.aah5982 · Cited by 574 · see citing works
“Moreover, protein levels of GluA1-containing AMPA receptors are higher after wake than after sleep(29) across the entire cerebral cortex.”
BackgroundHomer1a drives homeostatic scaling-down of excitatory synapses during sleep
Diering, G. H., Nirujogi, R. S., Roth, R. H., Worley, P. F., Pandey, A., & Huganir, R. L. (2017) · Science · doi:10.1126/science.aai8355 · Cited by 516 · see citing works
Sleep, Plasticity and Memory from Molecules to Whole-Brain Networks
Abel, T. G., Havekes, R., Saletin, J., & Walker, M. P. (2013) · Current Biology · doi:10.1016/j.cub.2013.07.025 · Cited by 551 · see citing works
“Consistent with this view, CREB phosphorylation within the hippocampus is elevated during REM sleep (Figure 2B) [16] and reduced after 5–6 hours of total sleep deprivation or longer periods of REM sleep deprivation (Figure 2C) [17–20] (but see [21]).”
Sleep viewed as a state of adaptive inactivity
Siegel, J. M. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2697 · Cited by 468 · see citing works
The slow (<1 Hz) rhythm of non-REM sleep: a dialogue between three cardinal oscillators
Crunelli, V., & Hughes, S. W. (2010) · Nature Neuroscience · doi:10.1038/nn.2445 · Cited by 435 · see citing works
Genetics of Sleep and Sleep Disorders
Sehgal, A., & Mignot, E. J.-M. (2011) · Cell · doi:10.1016/j.cell.2011.07.004 · Cited by 407 · see citing works
Kurth, S., Ringli, M., Geiger, A., LeBourgeois, M., Jenni, O. G., & Huber, R. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2532-10.2010 · Cited by 373 · see citing works
“, synaptic strength generally decreases during sleep and increases during wakefulness (Esser et al., 2007; Vyazovskiy et al., 2008).”
BackgroundThe genetic and molecular regulation of sleep: from fruit flies to humans
Cirelli, C. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2683 · Cited by 382 · see citing works
“Consistent with this, recent experiments in flies and rats showed that molecular and electrophysiological markers of net synaptic potentiation prevailed in waking, whereas markers of net synaptic depression prevailed in slee”
Widespread Changes in Synaptic Markers as a Function of Sleep and Wakefulness in <i>Drosophila</i>
Gilestro, G. F., Tononi, G., & Cirelli, C. (2009) · Science · doi:10.1126/science.1166673 · Cited by 360 · see citing works
Self-citationSleep and Synaptic Homeostasis: Structural Evidence in <i>Drosophila</i>
Bushey, D., Tononi, G., & Cirelli, C. (2011) · Science · doi:10.1126/science.1202839 · Cited by 357 · see citing works
Glucocorticoids are critical regulators of dendritic spine development and plasticity in vivo
Liston, C., & Gan, W.-B. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110444108 · Cited by 352 · see citing works
“Sleep and prolonged wakefulness, in turn, are associated with contrasting changes in the expression of genes associated with cortical plasticity (41, 42).”
BackgroundRaven, F., Van der Zee, E. A., Meerlo, P., & Havekes, R. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2017.05.002 · Cited by 331 · see citing works
Sleep and waking modulate spine turnover in the adolescent mouse cortex
Maret, S., Faraguna, U., Nelson, A. B., Cirelli, C., & Tononi, G. (2011) · Nature Neuroscience · doi:10.1038/nn.2934 · Cited by 315 · see citing works
Self-citationHuman Cortical Excitability Increases with Time Awake
Huber, R., Mäki, H., Rosanova, M., Casarotto, S., Canali, P., Casali, A. G., Tononi, G., & Massimini, M. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs014 · Cited by 308 · see citing works
“In the present work, we assessed the excitability of human cortical circuits by an approach that is closer to the one employed in the animal model, where the amplitude and the slope of the early LFP response to cortical stimulation is measured (Bliss and Lomo 1973; Vyazovskiy et al. 2008).”
BackgroundMethodInfluentialKreutzmann, J. C., Havekes, R., Abel, T., & Meerlo, P. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.04.053 · Cited by 309 · see citing works
“For instance, whereas one study performed Western blot analysis specifically on synaptoneurosomal fractions (Vyazovskiy et al., 2008), others used membrane fractions or whole homogenates (e.”
BackgroundResultInfluentialNeuronal Firing Rate Homeostasis Is Inhibited by Sleep and Promoted by Wake
Hengen, K. B., Pacheco, A. T., McGregor, J. N., Hooser, S. D. V., & Turrigiano, G. G. (2016) · Cell · doi:10.1016/j.cell.2016.01.046 · Cited by 295 · see citing works
“Some studies (Vyazovskiy et al., 2008, 2009), but not others (Grosmark et al., 2012), have observed an increase in firing across waking epochs.”
Glymphatic clearance controls state-dependent changes in brain lactate concentration
Lundgaard, I., Lu, M. L., Yang, E., Peng, W., Mestre, H., Hitomi, E., Deane, R., & Nedergaard, M. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16661202 · Cited by 300 · see citing works
“Other studies have in the past noted similar changes in gene expression mediated by LTP versus wakefulness.(79) Thus, it is possible that the suppression of glymphatic lactate clearance during wakefulness contributes to the characteristic expression of immediate early genes and thereby to memory consolidation.”
ResultHavekes, R., Park, A. J., Tudor, J. C., Luczak, V. G., Hansen, R. T., Ferri, S. L., Bruinenberg, V. M., Poplawski, S. G., Day, J. P., Aton, S. J., et al. (2016) · eLife · doi:10.7554/elife.13424 · Cited by 292 · see citing works
“Indeed, learning and memory, particularly those types mediated by the hippocampus, are promoted by sleep and disrupted by sleep deprivation ( Havekes et al., 2012a ; Abel et al., 2013 ; Whitney and Hinson, 2010 ).”
BackgroundSchmidt, M. H. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.08.001 · Cited by 291 · see citing works
Sleep Oscillations in the Thalamocortical System Induce Long-Term Neuronal Plasticity
Chauvette, S., Seigneur, J., & Timofeev, I. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.034 · Cited by 304 · see citing works
“Are there inconsistencies of our results with previous studies? (1) After prolonged waking periods, the slope of callosal evoked responses increases (Vyazovskiy et al., 2008).”
EEG sleep slow-wave activity as a mirror of cortical maturation
Buchmann, A., Ringli, M., Kurth, S., Schaerer, M., Geiger, A., Jenni, O. G., & Huber, R. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq129 · Cited by 273 · see citing works
“the physiological effects, for example, postsynaptic currents (Vyazovskiy et al. 2008).”
BackgroundHippocampal ripples down-regulate synapses
Norimoto, H., Makino, K., Gao, M., Shikano, Y., Okamoto, K., Ishikawa, T., Sasaki, T., Hioki, H., Fujisawa, S., & Ikegaya, Y. (2018) · Science · doi:10.1126/science.aao0702 · Cited by 262 · see citing works
Cortical circuit activity underlying sleep slow oscillations and spindles
Niethard, N., Ngo, H.-V. V., Ehrlich, I., & Born, J. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1805517115 · Cited by 245 · see citing works
Light and Cognition: Roles for Circadian Rhythms, Sleep, and Arousal
Fisk, A. S., Tam, S. K. E., Brown, L. A., Vyazovskiy, V. V., Bannerman, D. M., & Peirson, S. N. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00056 · Cited by 278 · see citing works
“Critically, GluA1 levels in synaptoneurosomes in both the cortex and hippocampus have been shown to be elevated following prolonged wakefulness (156).”
BackgroundDash, M. B., Douglas, C. L., Vyazovskiy, V. V., Cirelli, C., & Tononi, G. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5486-08.2009 · Cited by 278 · see citing works
“Strikingly, cerebral metabolism in mice is also contingent upon the sleep–waking history (Vyazovskiy et al., 2008a).”
BackgroundInfluentialSleep Neurobiology from a Clinical Perspective
España, R. A., & Scammell, T. E. (2011) · SLEEP · doi:10.5665/sleep.1112 · Cited by 282 · see citing works
Cortisol Inhibits Neuroplasticity Induction in Human Motor Cortex
Sale, M. V., Ridding, M. C., & Nordstrom, M. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1963-08.2008 · Cited by 270 · see citing works
“LTP in rat cerebral cortex is induced more readily 1– 60 min after sleep than after several hours of wakefulness (Vyazovskiy et al., 2008).”
BackgroundSleep-wake cycles drive daily dynamics of synaptic phosphorylation
Brüning, F., Noya, S. B., Bange, T., Koutsouli, S., Rudolph, J. D., Tyagarajan, S. K., Cox, J., Mann, M., Brown, S. A., & Robles, M. S. (2019) · Science · doi:10.1126/science.aav3617 · Cited by 261 · see citing works
Effects of Sleep and Wake on Oligodendrocytes and Their Precursors
Bellesi, M., Pfister‐Genskow, M., Maret, S., Keleş, S., Tononi, G., & Cirelli, C. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5102-12.2013 · Cited by 254 · see citing works
“, 2009), and the expression of synaptic-enriched GluR1-containing AMPA receptors (Vyazovskiy et al., 2008) and their currents (Lante et al.”
BackgroundTuning pathological brain oscillations with neurofeedback: a systems neuroscience framework
Ros, T., Baars, B. J., Lanius, R. A., & Vuilleumier, P. O. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.01008 · Cited by 263 · see citing works
Genzel, L., Kroes, M. C. W., Dresler, M., & Battaglia, F. P. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.10.002 · Cited by 259 · see citing works
Why We Sleep: The Temporal Organization of Recovery
Mignot, E. J.-M. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060106 · Cited by 266 · see citing works
Duncan, W. C., Sarasso, S., Ferrarelli, F., Selter, J., Riedner, B. A., Hejazi, N. S., Yuan, P., Brutsche, N., Manji, H. K., Tononi, G., et al. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000545 · Cited by 256 · see citing works
“2008) and result in an overall slowing of resting EEG activity (Hughes, 1996 ; Vyazovskiy et al. 2008).”
InfluentialNeuromodulation of Spike-Timing-Dependent Plasticity: Past, Present, and Future
Brzosko, Z., Mierau, S. B., & Paulsen, O. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.041 · Cited by 247 · see citing works
Mechanisms of sleep-dependent consolidation of cortical plasticity
Aton, S. J., Seibt, J., Dumoulin, M., Jha, S. K., Steinmetz, N., Coleman, T., Naidoo, N., & Frank, M. G. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.007 · Cited by 244 · see citing works
“First, we investigated a naturally occurring form of plasticity in vivo, whereas these authors examined artificial forms of induced plasticity (or electrically evoked responses) and gene and protein expression in animals whose brains were not stimulated to remodel (Cirelli et al., 2004; Vyazovskiy et al., 2008 ).”
BackgroundResultLaminar analysis of slow wave activity in humans
Csercsa, R., Dombovári, B., Fabó, D., Wittner, L., Erőss, L., Entz, L., Sólyom, A., Rásonyi, G., Szűcs, A., Kelemen, A., et al. (2010) · Brain · doi:10.1093/brain/awq169 · Cited by 239 · see citing works
“, 2007) and synaptic strength normalization (Vyazovskiy et al., 2008).”
BackgroundInfluentialGenetics of circadian rhythms and sleep in human health and disease
Lane, J. M., Qian, J., Mignot, E., Redline, S., Scheer, F. A. J. L., & Saxena, R. (2023) · Nature Reviews Genetics · doi:10.1038/s41576-022-00519-z · Cited by 236 · see citing works
The relation of ongoing brain activity, evoked neural responses, and cognition
Sadaghiani, S. (2010) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2010.00020 · Cited by 225 · see citing works
Circadian regulation of human cortical excitability
Ly, J. Q. M., Gaggioni, G., Chellappa, S. L., Papachilleos, S., Brzozowski, A., Borsu, C., Rosanova, M., Sarasso, S., Middleton, B., Luxen, A., et al. (2016) · Nature Communications · doi:10.1038/ncomms11828 · Cited by 226 · see citing works
Beltramo, R., D’Urso, G., Maschio, M. D., Farisello, P., Bovetti, S., Clovis, Y. M., Lassi, G., Tucci, V., Tonelli, D. D. P., & Fellin, T. (2013) · Nature Neuroscience · doi:10.1038/nn.3306 · Cited by 224 · see citing works
Unraveling the evolutionary determinants of sleep
Joiner, W. J. (2016) · Current Biology · doi:10.1016/j.cub.2016.08.068 · Cited by 232 · see citing works
Liu, Z.-W., Faraguna, U., Cirelli, C., Tononi, G., & Gao, X.-B. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1409-10.2010 · Cited by 248 · see citing works
“…slices are consistent with the report that the slope and amplitude of field potentials increase in wake and decrease in sleep in freely moving rats (Vyazovskiy et al., 2008), and with similar observations in humans using transcranial magnetic stimulation and high-density EEG (Bellina et al., 2008).”
BackgroundMethodResultInfluentialLocal Experience-Dependent Changes in the Wake EEG after Prolonged Wakefulness
Hung, C., Sarasso, S., Ferrarelli, F., Riedner, B. A., Ghilardi, M. F., Cirelli, C., & Tononi, G. (2012) · SLEEP · doi:10.5665/sleep.2302 · Cited by 224 · see citing works
Karabanov, A. N., Ziemann, U., Hamada, M., George, M. S., Quartarone, A., Claßen, J., Massimini, M., Rothwell, J. C., & Siebner, H. R. (2015) · Brain stimulation · doi:10.1016/j.brs.2015.01.404 · Cited by 224 · see citing works
“From a molecular point of view, the levels of GluA1-containing AMPA receptors (a molecular marker of synaptic potentiation) were found to be 30 e 40% higher after wakefulness than after sleep in rats [117].”
Sleep and synaptic down-selection
Tononi, G., & Cirelli, C. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14335 · Cited by 217 · see citing works
“Of note, in adult rats, levels of phosphorylated GSK- 3ß are higher in wake than in sleep (Vyazovskiy et al., 2008).”
InfluentialInvolvement of Ca2+-Dependent Hyperpolarization in Sleep Duration in Mammals
Tatsuki, F., Sunagawa, G. A., Shi, S., Susaki, E. A., Yukinaga, H., Perrin, D., Sumiyama, K., Ukai‐Tadenuma, M., Fujishima, H., Ohno, R.-I., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.02.032 · Cited by 196 · see citing works
“Although some experimental results support the synaptic homeostasis hypothesis (Vyazovskiy et al., 2008), others challenge it (Yang et al., 2014).”
Hinard, V., Mikhail, C., Pradervand, S., Curie, T., Houtkooper, R. H., Auwerx, J. H., Franken, P., & Tafti, M. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2306-12.2012 · Cited by 202 · see citing works
“…far, the evidence is based on glucose metabolism or gene expression related to metabolism of lipids and proteins (Kennedy et al., 1982; Everson et al., 1994; Cirelli and Tononi, 2000b; Netchiporouk et al., 2001; Franken et al., 2003; Brown, 2004; Mackiewicz et al., 2007; Vyazovskiy et al., 2008a).”
BackgroundCarvalho, D. Z., Louis, E. K. S., Knopman, D. S., Boeve, B. F., Lowe, V. J., Roberts, R. O., Mielke, M. M., Przybelski, S. A., Machulda, M. M., Petersen, R. C., et al. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2018.0049 · Cited by 207 · see citing works
“However,Aβ42generation isalso influencedbysynapticactivity,(24,25,63)which ismaximumduringwakefulnessanddecreasedafter sleep, correlating with slowwave activity.(64) Slowwave activity reduces cerebral cortexmetabolism(65)andalsoappears topromotedownscaling of synaptic connections.”
Control and Function of the Homeostatic Sleep Response by Adenosine A1Receptors
Bjorness, T. E., Kelly, C., Gao, T., Poffenberger, V., & Greene, R. W. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2942-08.2009 · Cited by 201 · see citing works
“It has been suggested that sleep function is involved in the consolidation of learning (Walker and Stickgold, 2004; Stickgold and Walker, 2005) or in the global homeostasis of synaptic plasticity of learning and memory (Vyazovskiy et al., 2008), based on observations of performance with or without intervening episodes…”
BackgroundSleep-Dependent Improvement in Visuomotor Learning: A Causal Role for Slow Waves
Crupi, D., Hulse, B. K., Peterson, M. J., Huber, R., Ansari, H., Coen, M., Cirelli, C., Benca, R. M., Ghilardi, M. F., & Tononi, G. (2009) · Sleep · doi:10.1093/sleep/32.10.1273 · Cited by 228 · see citing works
The role of metaplasticity mechanisms in regulating memory destabilization and reconsolidation
Finnie, P. S. B., & Nader, K. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.03.008 · Cited by 189 · see citing works
Krystal, J. H., Anticevic, A., Yang, G., Dragoi, G., Driesen, N. R., Wang, X., & Murray, J. D. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.01.004 · Cited by 195 · see citing works
“Sleep spindles may serve to enhance memory consolidation and to depotentiate synaptic connectivity in the service of eliminating “mnemonic background noise” (152,153).”
BackgroundHayashi, Y., Koyanagi, S., Kusunose, N., Okada, R., Wu, Z., Tozaki‐Saitoh, H., Ukai, K., Kohsaka, S., Inoue, K., Ohdo, S., et al. (2013) · Scientific Reports · doi:10.1038/srep02744 · Cited by 192 · see citing works
Havekes, R., Vecsey, C. G., & Abel, T. G. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.02.010 · Cited by 188 · see citing works
Common mechanisms of human perceptual and motor learning
Censor, N., Sagi, D., & Cohen, L. G. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3315 · Cited by 190 · see citing works
Hagewoud, R., Havekes, R., Novati, A., Keijser, J. N., van der Zee, E. A., & Meerlo, P. (2009) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2009.00799.x · Cited by 187 · see citing works
A pivotal role of GSK-3 in synaptic plasticity
Bradley, C. A., Peineau, S., Taghibiglou, C., Nicolas, C. S., Whitcomb, D. J., Bortolotto, Z. A., Kaang, B., Cho, K., Wang, Y. T., & Collingridge, G. L. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00013 · Cited by 189 · see citing works
“The sleep state (relative to awake state) was associated with low Ser9 phosphorylation of GSK-3β, and hence greater activity and low GluA1 levels as well as a long lasting depression of responses to evoked stimulation (Vyazovskiy et al., 2008).”
BackgroundChanges in EEG multiscale entropy and power‐law frequency scaling during the human sleep cycle
Miskovic, V., MacDonald, K. J., Rhodes, L. J., & Côté, K. A. (2018) · Human Brain Mapping · doi:10.1002/hbm.24393 · Cited by 178 · see citing works
The role of sleep in recovery following ischemic stroke: A review of human and animal data
Duss, S. B., Seiler, A., Schmidt, M. H., Pace, M., Adamantidis, A., Müri, R. M., & Bassetti, C. L. (2016) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2016.11.003 · Cited by 182 · see citing works
Ravassard, P., Pachoud, B., Comte, J.-C., Mejia-Perez, C., Scoté-Blachon, C., Gay, N., Claustrat, B., Touret, M., Luppi, P.-H., & Salin, P. A. (2009) · Sleep · doi:10.1093/sleep/32.2.227 · Cited by 177 · see citing works
Neuronal Activity Regulates Blood-Brain Barrier Efflux Transport through Endothelial Circadian Genes
Pulido, R. S., Munji, R. N., Chan, T. C., Quirk, C. R., Weiner, G., Weger, B. D., Rossi, M., Elmsaouri, S., Malfavon, M., Deng, A., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.09.002 · Cited by 172 · see citing works
“Mice are active during their dark period (ZT12-ZT24) and rest during their light period (ZT0-ZT12), thus exhibiting higher excitatory neuronal activity during the dark period associated with wakefulness and lower excitatory neuronal activity during the light period associated with sleep (Vyazovskiy et al., 2008; Bero…”
Sculpting memory during sleep: concurrent consolidation and forgetting
Feld, G. B., & Jan Born, A. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.02.012 · Cited by 170 · see citing works
“Likewise the amount of AMPA receptors on glutamatergic neurons is reduced across sleep [47].”
Circadian and Homeostatic Regulation of Structural Synaptic Plasticity in Hypocretin Neurons
Appelbaum, L., Wang, G. X., Yokogawa, T., Skariah, G. M., Smith, S. J., Mourrain, P., & Mignot, E. J.-M. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.006 · Cited by 172 · see citing works
“Further, induction of long-term potentiation (LTP) is diminished after wakefulness and restored after sleep (Vyazovskiy et al., 2008).”
BackgroundCircadian clocks: genes, sleep, and cognition
Kyriacou, C. P., & Hastings, M. H. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.03.007 · Cited by 171 · see citing works
Calcium regulation of neural rhythms, memory and Alzheimer's disease
Berridge, M. J. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.257527 · Cited by 170 · see citing works
“This synaptic homeostasis hypothesis proposes that the redundant information stored in those potentiated synaptic connections are returned to baseline levels during sleep (Tononi & Cirelli, 2006; Vyazovskiy et al. 2008).”
BackgroundCanto, C. B., Onuki, Y., Bruinsma, B., van der Werf, Y. D., & Zeeuw, C. I. D. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.03.001 · Cited by 168 · see citing works
“Trends in Neurosciences, May 2017, Vol. 40, No. 5 315 Correla on with slow spindle (11-13Hz) Lobule IV-V LR Schabus et al., 2007; fMRI Nega vely correla on with delta ac vity Lobule VIIa Crus I (Hem) LR Hofle et al., 1997; fMRI NREM1 < Wake Lobule VII A Crus II (Hem) LR Kjaer et al., 2002; PET REM > Wake (post-sleep)…”
InfluentialSleep Interacts with Aβ to Modulate Intrinsic Neuronal Excitability
Tabuchi, M., Lone, S. R., Liu, S., Liu, Q., Zhang, J., Spira, A. P., & Wu, M. N. (2015) · Current Biology · doi:10.1016/j.cub.2015.01.016 · Cited by 165 · see citing works
Bayer, T. A., & Wirths, O. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1287-x · Cited by 168 · see citing works
“A physiological effect of the observed diurnal variation of ISF Aβ could be the known overall increase in synaptic strength during the day and synaptic depression during periods of sleep [20, 24, 100].”
Sleep recalibrates homeostatic and associative synaptic plasticity in the human cortex
Kuhn, M., Wolf, E., Maier, J. G., Mainberger, F., Feige, B., Schmid, H., Bürklin, J., Maywald, S., Mall, V., Jung, N. H., et al. (2016) · Nature Communications · doi:10.1038/ncomms12455 · Cited by 152 · see citing works
Karabanov, A. N., Ziemann, U., Hamada, M., George, M. S., Quartarone, A., Claßen, J., Massimini, M., Rothwell, J. C., & Siebner, H. R. (2015) · Brain stimulation · doi:10.1016/j.brs.2015.06.017 · Cited by 159 · see citing works
Schmitt, L. I., Sims, R. E., Dale, N., & Haydon, P. G. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5689-11.2012 · Cited by 162 · see citing works
Ras and Rap Signaling in Synaptic Plasticity and Mental Disorders
Stornetta, R. L., & Zhu, J. (2010) · The Neuroscientist · doi:10.1177/1073858410365562 · Cited by 159 · see citing works
Sleep homeostasis in the rat is preserved during chronic sleep restriction
Leemburg, S., Vyazovskiy, V. V., Olcese, U., Bassetti, C. L., Tononi, G., & Cirelli, C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002570107 · Cited by 154 · see citing works
Peripheral and central inputs shape network dynamics in the developing visual cortex in vivo
Siegel, F., Heimel, J. A., Peters, J., & Lohmann, C. (2012) · Current Biology · doi:10.1016/j.cub.2011.12.026 · Cited by 142 · see citing works
An inhibitory gate for state transition in cortex
Zucca, S., D’Urso, G., Pasquale, V., Vecchia, D., Pica, G., Bovetti, S., Moretti, C., Varani, S., Molano‐Mazón, M., Chiappalone, M., et al. (2017) · eLife · doi:10.7554/elife.26177 · Cited by 157 · see citing works
“…modulation of sensory inputs (Petersen et al., 2003a; Haider et al., 2007; Reig et al., 2015), the regulation of synaptic plasticity (Rosanova and Ulrich, 2005; Vyazovskiy et al., 2008), and the control of memory consolidation (Diekelmann and Born, 2010; Miyamoto et al., 2016; Rasch et al., 2007).”
BackgroundResultInfluentialMolecular Mechanisms of Sleep Homeostasis in Flies and MammalsPreprint
Allada, R., Cirelli, C., & Sehgal, A. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a027730 · Cited by 155 · see citing works
Sadowski, J. H. L. P., Jones, M. W., & Mellor, J. R. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.01.061 · Cited by 159 · see citing works
“Others suggest that sleep provides a vital opportunity for synaptic downscaling (Vyazovskiy et al., 2008; Maret et al., 2011) following cumulative potentiation during wakefulness and that further potentiation during sleep could harm memory encoding (Tononi and Cirelli, 2014).”
BackgroundIndividual Differences in White Matter Diffusion Affect Sleep Oscillations
Piantoni, G., Poil, S., Linkenkaer‐Hansen, K., Verweij, I. M., Ramautar, J. R., Someren, E. J. W. V., & van der Werf, Y. D. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2030-12.2013 · Cited by 152 · see citing works
Daily Oscillation of the Excitation-Inhibition Balance in Visual Cortical Circuits
Bridi, M., Zong, F., Min, X., Luo, N., Tran, T., Qiu, J., Severín, D., Zhang, X., Wang, G., Zhu, Z., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.11.011 · Cited by 139 · see citing works
Deep sleep maintains learning efficiency of the human brain
Fattinger, S., de Beukelaar, T. T., Ruddy, K. L., Volk, C., Heyse, N. C., Herbst, J. A., Hahnloser, R. H. R., Wenderoth, N., & Huber, R. (2017) · Nature Communications · doi:10.1038/ncomms15405 · Cited by 148 · see citing works
Functional interactions between intrinsic brain activity and behavior
Sadaghiani, S., & Kleinschmidt, A. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.100 · Cited by 147 · see citing works
“The most prominent example is the optimization (consolidation) of synaptic connections during sleep (Diekelmann and Born, 2010; Vyazovskiy et al., 2008).”
BackgroundSleep and circadian rhythmicity as entangled processes serving homeostasis
Franken, P., & Dijk, D.-J. (2024) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00764-z · Cited by 147 · see citing works
“Characteristics of slow waves, such as their incidence, amplitude and slopes that have been considered (although not universally accepted) as electrophysiological markers of synaptic strength 76 , are also modulated by circadian phase 60 .”
- Authors
- Vyazovskiy, V. V., Cirelli, C., Pfister-Genskow, M., Faraguna, U., & Tononi, G.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Cirelli, Chiara
- Tononi, Giulio
- Venue
- Nature Neuroscience
- Published
- 2008-01-20
- Volume
- 11
- Issue
- 2
- Pages
- 200-208
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2109919607
- Cited by
- 837
- References
- 53
- Citations by year
- 2026: 27 · 2025: 48 · 2024: 49 · 2023: 28 · 2022: 44 · 2021: 48 · 2020: 40 · 2019: 60 · 2018: 37 · 2017: 57 · 2016: 36 · 2015: 43 · 2014: 45 · 2013: 62 · 2012: 53
- FWCI
- 26.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Open Research (University of Surrey) (submittedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- National Institutes of Health (DP1OD000579)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- synaptic potentiation, synaptic depression, sleep, wakefulness, AMPA receptors, GluR1, receptor phosphorylation, CaMKII, GSK3β, slow-wave activity, sleep pressure, cortical evoked potentials, long-term potentiation, memory consolidation, hippocampus, cortex, synaptic plasticity
- MeSH terms
- Glycogen Synthase Kinase 3 beta, Animals, Behavior, Animal, Cerebral Cortex, Electroencephalography, Electromyography, Gene Expression Regulation, Hippocampus, Male, Neuronal Plasticity, Phosphorylation, Rats, Inbred WKY, Serine, Sleep, Synapses, Temperature, Threonine, Wakefulness, Receptors, AMPA, Glycogen Synthase Kinase 3, Rats, Calcium-Calmodulin-Dependent Protein Kinase Type 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
