The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Variation within and among species in gene expression: raw material for evolution
Abstract
Heritable variation in regulatory or coding regions is the raw material for evolutionary processes. The advent of microarrays has recently promoted examination of the extent of variation in gene expression within and among taxa and examination of the evolutionary processes affecting variation. This review examines these issues. We find: (i) microarray‐based measures of gene expression are precise given appropriate experimental design; (ii) there is large inter‐individual variation, which is composed of a minor nongenetic component and a large heritable component; (iii) variation among populations and species appears to be affected primarily by neutral drift and stabilizing selection, and to a lesser degree by directional selection; and (iv) neutral evolutionary divergence in gene expression becomes nonlinear with greater divergence times due to functional constraint. Evolutionary analyses of gene expression reviewed here provide unique insights into partitioning of regulatory variation in nature. However, common limitations of these studies include the tendency to assume a linear relationship between expression divergence and species divergence, and failure to test explicit hypotheses that involve the ecological context of evolutionary divergence.
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Cites
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Cited by
QST–FST comparisons: evolutionary and ecological insights from genomic heterogeneity
Leinonen, T., McCairns, R. J. S., O'Hara, R. B., & Merilä, J. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3395 · Cited by 422
Regulatory divergence in Drosophila revealed by mRNA-seq
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Evolution of primate gene expression
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Conservation of core gene expression in vertebrate tissues
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Metadata
- Authors
- WHITEHEAD, A., & CRAWFORD, D. L.
- Venue
- Molecular Ecology
- Publisher
- Wiley
- Published
- 2006-03-16
- Volume
- 15
- Issue
- 5
- Pages
- 1197-1211
- ISSN
- 0962-1083 (ISSN-L)
- 1365-294X
- OpenAlex
- W2130317490
- Cited by
- 345
- References
- 12
- FWCI
- 15.90
- Type
- journal article
- Language
- en
- Open access
- closed
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