Cited by 216Primate Behavior and EcologyGenomic variations and chromosomal abnormalitiesGenetics and Neurodevelopmental Disorders

Human brain evolution: insights from microarrays

Preuss, Todd M., Cáceres, Mario, Oldham, Michael C., Geschwind, Daniel H.·2004·Nature Reviews Genetics

Abstract

Several recent microarray studies have compared gene-expression patterns n humans, chimpanzees and other non-human primates to identify evolutionary changes that contribute to the distinctive cognitive and behavioural characteristics of humans. These studies support the surprising conclusion that the evolution of the human brain involved an upregulation of gene expression relative to non-human primates, a finding that could be relevant to understanding human cerebral physiology and function. These results show how genetic and genomic methods can shed light on the basis of human neural and cognitive specializations, and have important implications for neuroscience, anthropology and medicine.

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Crossref · 10.1038/nrg1469

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  • Comparative microarray studies have shown a high degree of conservation across species in overall gene expression, although there is considerable upregulation of brain gene expression in humans compared to non-human primates.

    “However, comparative microarray studies have shown a high degree of conservation across species in overall gene expression, although there is considerable upregulation of brain gene expression in humans compared to non-human primates (Khaitovich et al., 2006; Preuss et al., 2004; Vallender et al., 2008).”

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Authors
Preuss, T. M., Cáceres, M., Oldham, M. C., & Geschwind, D. H.
Affiliations
  • Emory University (US)
  • University of California, Los Angeles (US)
Corresponding author
  • Preuss, Todd M.
  • Geschwind, Daniel H.
Venue
Nature Reviews Genetics
Published
2004-11
Volume
5
Issue
11
Pages
850-860
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
OpenAlex
W2062073165
Cited by
215
References
85
Citations by year
2026: 1 · 2025: 4 · 2024: 12 · 2023: 6 · 2022: 1 · 2021: 8 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 6 · 2016: 6 · 2015: 7 · 2014: 6 · 2013: 13 · 2012: 14
FWCI
3.35
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Genetics (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • James S. McDonnell Foundation
  • National Institutes of Health
  • National Institute of Mental Health
Topics
  • Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
human brain evolution, gene expression, comparative genomics, chimpanzees, non-human primates, neural specialization
MeSH terms
Animals, Brain, Biological Evolution, Humans, Species Specificity, Gene Expression, Oligonucleotide Array Sequence Analysis

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