The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
A specific secretion system mediates PPE41 transport in pathogenic mycobacteria
Abstract
Summary: Mycobacterial genomes contain two unique gene families, the so‐called PE and PPE gene families, which are highly expanded in the pathogenic members of this genus. Here we report that one of the PPE proteins, i.e. PPE41, is secreted by pathogenic mycobacteria, both in culture and in infected macrophages. As PPE41 lacks a signal sequence a dedicated secretion system must be involved. A single gene was identified in Mycobacterium marinum that showed strongly reduced PPE41 secretion. This gene was located in a gene cluster whose predicted proteins encode components of an ESAT‐6‐like secretion system. This cluster, designated ESX‐5, is conserved in various pathogenic mycobacteria, but not in the saprophytic species Mycobacterium smegmatis . Therefore, different regions of this cluster were introduced in M. smegmatis . Only introduction of the complete ESX‐5 locus resulted in efficient secretion of heterologously expressed PPE41. This PPE secretion system is also involved in the virulence of pathogenic mycobacteria, as the ESX‐5 mutant of M. marinum was affected in spreading to uninfected macrophages.
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Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
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Protein Kinase G from Pathogenic Mycobacteria Promotes Survival Within Macrophages
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Cited by
Type VII secretion — mycobacteria show the way
Abdallah, A. M., Gey van Pittius, N. C., DiGiuseppe Champion, P. A., Cox, J., Luirink, J., Vandenbroucke-Grauls, C. M. J. E., Appelmelk, B. J., & Bitter, W. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1773 · Cited by 763
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ESX secretion systems: mycobacterial evolution to counter host immunity
Gröschel, M. I., Sayes, F., Simeone, R., Majlessi, L., & Brosch, R. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.131 · Cited by 382
Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis
Tobin, D. M., & Ramakrishnan, L. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01133.x · Cited by 343
Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition
Siegrist, M. S., Unnikrishnan, M., McConnell, M. J., Borowsky, M., Cheng, T.-Y., Siddiqi, N., Fortune, S. M., Moody, D. B., & Rubin, E. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900589106 · Cited by 337
Metadata
- Authors
- Abdallah, A. M., Verboom, T., Hannes, F., Safi, M., Strong, M., Eisenberg, D., Musters, R. J. P., Vandenbroucke‐Grauls, C. M. J. E., Appelmelk, B. J., Luirink, J., & Bitter, W.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2006-09-25
- Volume
- 62
- Issue
- 3
- Pages
- 667-679
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2040558306
- Cited by
- 234
- References
- 8
- FWCI
- 7.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Abdallah, A. M., Verboom, T., Hannes, F., Safi, M., Strong, M., Eisenberg, D., Musters, R. J. P., Vandenbroucke‐Grauls, C. M. J. E., Appelmelk, B. J., Luirink, J., & Bitter, W. (2006). A specific secretion system mediates PPE41 transport in pathogenic mycobacteria. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.2006.05409.x
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