The DOI matches its Crossref record; 268 of the 268 references it cites were found in a registry or an index.
Serotonergic and non‐serotonergic targets in the pharmacotherapy of visceral hypersensitivity
Abstract
Abstract Visceral hypersensitivity is considered a key mechanism in the pathogenesis of functional gastrointestinal (GI) disorders. Targeting visceral hypersensitivity seems an attractive approach to the development of drugs for functional GI disorders. This review summarizes current knowledge on targets for the treatment of visceral hypersensitivity, and the status of current and future drug and probiotic treatment development, and the role of pharmacogenomic factors.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The present study confirms these observations.”
In the citing paper
“The used B. lactis strain, HN019, has recently been shown to reduce intestinal transit in a placebo controlled dose ranging study [15,29].”
Citations
Cites
Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs
VANE, J. R. (1971) · Nature New Biology · doi:10.1038/newbio231232a0 · Cited by 8,605
Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H., & Murphy, D. L. (1996) · Science · doi:10.1126/science.274.5292.1527 · Cited by 5,162
Bombardier, C., Laine, L., Reicin, A. S., Shapiro, D., Burgos‐Vargas, R., Davis, B. R., Day, R. O., Ferraz, M. B., Hawkey, C. J., Hochberg, M. C., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200011233432103 · Cited by 4,014
Silverstein, F. E., Faich, G. A., Goldstein, J. L., Simon, L. S., Pincus, T., Whelton, A., Makuch, R., Eisen, G. M., Agrawal, N. M., Stenson, W. F., et al. (2000) · JAMA · doi:10.1001/jama.284.10.1247 · Cited by 3,144
Bacteriocins: Developing innate immunity for food
Cotter, P. D., Hill, C., & Ross, R. P. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1273 · Cited by 2,380
Allelic Variation of Human Serotonin Transporter Gene Expression
Heils, A., Teufel, A., Petri, S., Stöber, G., Riederer, P., Bengel, D., & Lesch, K. P. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66062621.x · Cited by 2,221
Probiotics, prebiotics, and synbiotics—approaching a definition
Schrezenmeir, J., & de Vrese, M. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.361s · Cited by 1,533
Barbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, G. S., Santini, D., Pasquinelli, G., Morselli-Labate, A. M., Grady, E. F., Bunnett, N. W., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.055 · Cited by 1,475
Hla, T., & Neilson, K. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7384 · Cited by 1,465
O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448
Self-citation
Research works printed but not linked: 6
- Tack J, 2004, A placebo‐controlled trial of the 5‐HT1A agonist R‐137696 on symptoms, visceral hypersensitivity and on impaired accommodation in functional dyspepsia, Gastroenterology, 126, A70
- Tack J, 2002, A phase II placebo controlled randomized trial with tegaserod in functional dyspepsia patients with normal gastric emptying, Gastroenterology, 122, A154
- Corsetti M, 2004, Influence of tegaserod on sensorimotor function of the descending colon in man, Gastroenterology, 126, A217
- Willert RP, 2006, Human visceral pain hypersensitivity is not attenuated by a selective oral neurokinin‐1 (NK‐1) receptor antagonist. A randomized double blind placebo controlled pharmacodynamic study in healthy volunteers, Gastroenterology, 130, A26
- Johanson ML, 2000, Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome, Am J Gastroenterol, 95, 1231, 10.1111/j.1572-0241.2000.02015.x · DOI · Paper page
- Parker P, 2003, Synbiotic in irritable bowel syndrome: a double blind prospective randomised controlled trial, Gut, 52, A11
Cited by
Sorted by citations
Serotonin, tryptophan metabolism and the brain-gut-microbiome axis
O’Mahony, S. M., Clarke, G., Borre, Y. E., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.027 · Cited by 2,012
Dimidi, E., Christodoulides, S., Fragkos, K. C., Scott, S. M., & Whelan, K. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.089151 · Cited by 316
Prebiotics and probiotics; modifying and mining the microbiota
Quigley, E. M. M. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2010.01.004 · Cited by 238
Magro, D. O., de Oliveira, L. M. R., Bernasconi, I., de Souza Ruela, M., Credidio, L., Barcelos, I. K., Leal, R. F., Ayrizono, M. D. L. S., Fagundes, J. J., Teixeira, L. D. B., et al. (2014) · Nutrition Journal · doi:10.1186/1475-2891-13-75 · Cited by 105
Quigley, E. M. M. (2011) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2010.12.009 · Cited by 67
Self-citation
Metadata
- Authors
- Bueno, L., De Ponti, F., Fried, M., Kullak‐ublick, G. A., Kwiatek, M. A., Pohl, D., Quigley, E. M. M., Tack, J., & Talley, N. J.
- Affiliations
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- University Hospital Zurich (CH)
- University College Cork (IE)
- KU Leuven (BE)
- Mayo Clinic (US)
- Corresponding author
- Bueno, L.
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2007-01
- Volume
- 19
- Issue
- s1
- Pages
- 89-119
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- OpenAlex
- W2032490947
- Cited by
- 64
- References
- 268
- Citations by year
- 2026: 1 · 2023: 2 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 4 · 2014: 4 · 2013: 1 · 2012: 2
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurogastroenterology & Motility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- visceral hypersensitivity, functional gastrointestinal disorders, pharmacotherapy, probiotics, pharmacogenomics, drug development
- MeSH terms
- Animals, Gastrointestinal Diseases, Humans, Receptors, Serotonin, Serotonin, Serotonin Antagonists, Pain Threshold, Visceral Afferents, Serotonin Agents, Probiotics, Gastrointestinal Tract, Cyclooxygenase 2 Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
