Cited by 64Gastrointestinal motility and disordersPain Mechanisms and TreatmentsPsychosomatic Disorders and Their Treatments

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Serotonergic and non‐serotonergic targets in the pharmacotherapy of visceral hypersensitivity

Bueno, L., De Ponti, F., Fried, M., Kullak‐ublick, G. A., Kwiatek, M. A., Pohl, D., Quigley, E. M. M., Tack, J., Talley, N. J.·2007·Neurogastroenterology & Motility

DOI 10.1111/j.1365-2982.2006.00876.x

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Abstract

Abstract Visceral hypersensitivity is considered a key mechanism in the pathogenesis of functional gastrointestinal (GI) disorders. Targeting visceral hypersensitivity seems an attractive approach to the development of drugs for functional GI disorders. This review summarizes current knowledge on targets for the treatment of visceral hypersensitivity, and the status of current and future drug and probiotic treatment development, and the role of pharmacogenomic factors.

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Authors: Bueno, L., De Ponti, F., Fried, M., Kullak‐ublick, G. A., Kwiatek, M. A., Pohl, D., Quigley, E. M. M., Tack, J., & Talley, N. J.
Affiliations: Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
University Hospital Zurich (CH)
University College Cork (IE)
KU Leuven (BE)
Mayo Clinic (US)
Corresponding author: Bueno, L.
ORCID: Pohl, D.
Quigley, E. M. M.
Tack, J.
Venue: Neurogastroenterology & Motility
Publisher: Wiley
Published: 2007-01
Volume: 19
Issue: s1
Pages: 89-119
ISSN: 1350-1925 (ISSN-L)
1365-2982
DOI: 10.1111/j.1365-2982.2006.00876.x
OpenAlex: W2032490947
Cited by: 64
References: 268
Citations by year: 2026: 1 · 2023: 2 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 4 · 2014: 4 · 2013: 1 · 2012: 2
FWCI: 1.41
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2 d)
Locations: Neurogastroenterology & Motility (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Keywords: visceral hypersensitivity, functional gastrointestinal disorders, pharmacotherapy, probiotics, pharmacogenomics, drug development
MeSH terms: Animals, Gastrointestinal Diseases, Humans, Receptors, Serotonin, Serotonin, Serotonin Antagonists, Pain Threshold, Visceral Afferents, Serotonin Agents, Probiotics, Gastrointestinal Tract, Cyclooxygenase 2 Inhibitors

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Serotonergic and non‐serotonergic targets in the pharmacotherapy of visceral hypersensitivity

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