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Increase in fecal primary bile acids and dysbiosis in patients with diarrhea‐predominant irritable bowel syndrome
Abstract
Background Irritable bowel syndrome (IBS) is a multifactorial disease for which a dysbiosis of the gut microbiota has been described. Bile acids (BA) could play a role as they are endogenous laxatives and are metabolized by gut microbiota. We compared fecal BA profiles and microbiota in healthy subjects (HS) and patients with diarrhea‐predominant IBS (IBS‐D), and we searched for an association with symptoms. Methods Clinical features and stool samples were collected in IBS‐D patients and HS. Fecal BA profiles were generated using HPLC coupled to tandem mass spectrometry. The fecal microbiota composition was assessed by q‐PCR targeting dominant bacterial groups and species implicated in BA transformation. Key Results Fourteen IBS‐D patients and 18 HS were included. The two groups were comparable in terms of age and sex. The percentage of fecal primary BA was significantly higher in IBS‐D patients than in HS, and it was significantly correlated with stool consistency and frequency. Fecal counts of all bacteria, lactobacillus, coccoides, leptum and Faecalibacterium prausnitzii were similar. There was a significant increase of Escherichia coli and a significant decrease of leptum and bifidobacterium in IBS‐D patients. Conclusions & Inferences We report an increase of primary BA in the feces of IBS‐D patients compared to HS, correlated with stool consistency and frequency. A dysbiosis of different bacterial groups was detected, some of them involved in BA transformation. As the gut microbiota is the exclusive pathway to transform primary into secondary BA, this suggests a functional consequence of dysbiosis, leading to lower BA transformation.
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“An increase in primary bile acids in faeces, associated with the decrease in C. leptum (able to transform primary into secondary bile acid), was correlated with the stool consistency in diarrhoea predominant IBS [65] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [65]
In the citing paper
“Interestingly, these differences correlated with stool consistency and frequency and were associated with decreased levels of the Clostridium leptum group, which contains many of the bacteria that can transform primary into secondary bile acid.”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [54]
In the citing paper
“Indeed, a recent small study in patients with IBS demonstrated increase of primary bile acid in the feces of patients with IBS-D compared with healthy subjects (54).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [54]
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Metadata
- Authors
- Duboc, H., Rainteau, D., Rajca, S., Humbert, L., Farabos, D., Maubert, M., Grondin, V., Jouet, P., Bouhassira, D., Seksik, P., Sokol, H., Coffin, B., & Sabaté, J. M.
- Affiliations
- Inserm (FR)
- Corresponding author
- Duboc, H.
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2012-02-22
- Volume
- 24
- Issue
- 6
- Pages
- 513
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- OpenAlex
- W1482883615
- Cited by
- 256
- References
- 42
- Citations by year
- 2026: 15 · 2025: 9 · 2024: 12 · 2023: 20 · 2022: 22 · 2021: 26 · 2020: 23 · 2019: 23 · 2018: 13 · 2017: 17 · 2016: 19 · 2015: 18 · 2014: 21 · 2013: 15 · 2012: 3
- FWCI
- 17.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurogastroenterology & Motility (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Microscopic Colitis
- Keywords
- diarrhea-predominant irritable bowel syndrome, primary bile acids, fecal bile acids, gut dysbiosis, stool consistency, stool frequency, Escherichia coli, Faecalibacterium prausnitzii, Leptospirillum, Bifidobacterium, lactobacilli
- MeSH terms
- Adult, Bile Acids and Salts, Colon, Diarrhea, DNA, Bacterial, Feces, Female, Humans, Intestinal Mucosa, Male, Middle Aged, Irritable Bowel Syndrome, Metagenome
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