Post–traumatic Alzheimer's disease: preponderance of a single plaque type
Abstract
The cause of Alzheimer's disease is unknown. Several factors have been proposed including head trauma. At present, the link between head injury and a subsequent neurodegenerative process is largely circumstantial, except in the case of dementia pugilistica (punch drunk syndrome) found in boxers. Recent studies have shown that the brains of boxers with this syndrome contain large numbers of ‘diffuse’ p–protein immunoreactive plaques. We supposed that this plaque type might be associated with trauma induced Alzheimer–like degeneration. In order to test this hypothesis we have re–investigated a previously Reported case of post–traumatic premature Alzheimer's disease. Immunocytochemistry using antibodies to amyloid β–protein revealed large numbers of ‘diffuse’ non–Congophilic plaques with little or no neuritic component. A similar preponderance of this plaque type is present in the brains of boxers with dementia pugilistica. Our observations support the idea of a trauma induced Alzheimer–like degenerative process and indicate that such a condition is associated with a marked preponderance of ‘diffuse’ plaques.
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Dementia pugilistica shows considerable intraneuronal Aβ42.
“In addition, dementia pugilistica that develops in professional boxers [31], while characterized by significant tauopathy and comparably less amyloid pathology, limited mainly to diffuse plaques [27], also shows considerable intraneuronal Aβ42 (Fig. 4c).”
From Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease (2010) · cites this paper as [27]
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- Authors
- CLINTON, J., AMBLER, M. W., & ROBERTS, G. W.
- Affiliations
- St Mary's Hospital (GB)
- Rhode Island Hospital (US)
- Corresponding author
- ROBERTS, G. W.
- ORCID
- ROBERTS, G. W.
- Venue
- Neuropathology and Applied Neurobiology
- Publisher
- Wiley
- Published
- 1991-02
- Volume
- 17
- Issue
- 1
- Pages
- 69-74
- ISSN
- 0305-1846 (ISSN-L)
- 1365-2990
- OpenAlex
- W1974546112
- Cited by
- 70
- References
- 21
- Citations by year
- 2022: 1 · 2020: 2 · 2019: 3 · 2018: 1 · 2014: 2 · 2013: 3 · 2012: 3
- FWCI
- 5.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropathology and Applied Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Keywords
- diffuse plaques, amyloid-beta, head trauma, chronic traumatic encephalopathy, boxing, neuritic plaques
- MeSH terms
- Adult, Alzheimer Disease, Brain, Brain Injuries, Cerebral Cortex, Humans, Immunohistochemistry, Male, Amyloid beta-Peptides
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