CoChat
Sign Up
Cited by 213Alzheimer's disease research and treatmentsTraumatic Brain Injury ResearchDementia and Cognitive Impairment Research

Differential distribution of neurofibrillary tangles in the cerebral cortex of dementia pugilistica and Alzheimer's disease cases

Hof, P. R., Bouras, C., Bu�e, L., Delacourte, A., Perl, D. P., Morrison, J. H.·1992·Acta Neuropathologica
DOI 10.1007/bf00304630
Open this paper in CoChat — free account

Abstract

Head trauma has been associated with the occurrence of Alzheimer's disease and plays a clear role in the etiopathogenesis of the boxers encephalopathy referred to as dementia pugilistica. Neurofibrillary tangles (NFT), one of the pathological hallmarks of Alzheimer's disease are observed in very high densities in the brains of former professional boxers suffering from dementia pugilistica. In Alzheimer's disease, NFT display striking regional and laminar distribution patterns that have been correlated with the localization of neurons forming specific corticocortical connections. In dementia pugilistica cases, NFT were concentrated in the superficial layers in the neocortex, whereas in Alzheimer's disease they predominated in the deep layers. Thus, the association cortex of brains from dementia pugilistica patients demonstrated an inverse NFT distribution as compared to Alzheimer's disease. This finding suggests that a more circumscribed population of cortical pyramidal neurons might be affected in dementia pugilistica than in Alzheimer's disease.

Integrity signals

Registry

Crossref · 10.1007/bf00304630

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • PHF-tau immunoreactive NFTs in CTE are preferentially distributed to the superficial layers of the cerebral cortex (layers II and upper third of layer III).

    “The observation that PHF-tau immunoreactive NFTs in CTE are preferentially distributed to the superficial layers of the cerebral cortex (layers II and upper third of layer III) was made by Hof, who noted the similarity between the superficial distribution of NFTs in CTE and two other environmentally triggered tauopathies, post-encephalitic Parkinson disease and Guamanian ALS parkinsonism/dementia”

    From The neuropathology of sport (2014) · cites this paper as [91]

  • Despite evidence for Ab deposition in moderate to severe TBI, Ab plaques have not been found in early or mild stages of CTE in young individuals, but occur in older subjects with CTE in association with increased age at death.

    “However, despite evidence for Ab deposition in moderate to severe TBI [94], Ab plaques have not been found in early or mild stages of CTE in young individuals [65, 66, 72, 91, 126] but occur in older subjects with CTE in association with increased age at death [128].”

    From The neuropathology of sport (2014) · cites this paper as [91]

  • CTE has been diagnosed neuropathologically in American football players, professional and amateur boxers, ice hockey players, professional wrestlers, soccer players, rugby players, and a professional baseball player.

    “Although CTE was first identified in association with boxing, CTE has been diagnosed neuropathologically in American football players, professional and amateur boxers, ice hockey players, professional wrestlers, soccer players, rugby players, and a professional baseball player (Figs. 3, 4, 5, 6) [38, 65, 66, 88, 91, 127, 128, 146–148].”

    From The neuropathology of sport (2014) · cites this paper as [91]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Hof, P. R., Bouras, C., Bu�e, L., Delacourte, A., Perl, D. P., & Morrison, J. H.
Affiliations
  • Icahn School of Medicine at Mount Sinai (US)
  • University of Geneva (CH)
  • Inserm (FR)
ORCID
Venue
Acta Neuropathologica
Publisher
Springer Science and Business Media LLC
Published
1992-12
Volume
85
Issue
1
Pages
23-30
ISSN
  • 0001-6322 (ISSN-L)
  • 1432-0533
DOI
10.1007/bf00304630
OpenAlex
W2003313975
Semantic Scholar
7a34b3f1656f111251392006deedc7efa43e5621
Cited by
213
References
60
Citations by year
2026: 2 · 2025: 6 · 2024: 10 · 2023: 11 · 2022: 9 · 2021: 11 · 2020: 12 · 2019: 13 · 2018: 10 · 2017: 11 · 2016: 13 · 2015: 16 · 2014: 6 · 2013: 7 · 2012: 7
FWCI
2.38
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Acta Neuropathologica (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (AG 05138, P50AG005138, AG-06647)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
neurofibrillary tangles, chronic traumatic encephalopathy, Alzheimer's disease, cerebral cortex, head trauma, boxing, association cortex, pyramidal neurons, corticocortical connections
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Boxing, Cerebral Cortex, Dementia, Humans, Immunohistochemistry, Male, Middle Aged, Amyloid beta-Peptides, Neurofibrillary Tangles, tau Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review