The Use of Insect Development Inhibitors as an Oral Medication for the Control of the Fleas Ctenocephalides felis, Ct. canis in the Dog and Cat
Abstract
Résumé—Il existe deux inhibiteurs de croissance des insectes (ICI) sous forme orale pour le contrôle des puces. Le lufénuron s'administre une fois par mois à la dose de 10 mg/kg chez le chien et 30 mg/kg chez le chat. La cyromazine s'administre quotidiennement à la dose de 10 mg/kg en association avec la diethylcarbamazine chez le chien. Aucun des deux produits n'est actif sur la puce adulte, mais cause plutôt une interruption de la production de chitine normale par différents modes d'actions spécifiques. Ceci entraine la mort des formes immatures de puces. Par conséquent, les 2 produits contrôle l'infestation par les puces adultes sur l'animal par le biais de l'élimination des formes immatures présentes dans le milieu. Il existe un délai de 6 à 8 semaines entre 1'administration d'inhibiteurs de croissance des insectes (ICI) et la reduction du nombre de puces adultes sur les animaux traités. Cette période réfractaire est due à la survie de puces immatures présentes dans le milieu avant le traitement aux ICI; elle peut être réduite si l'on démarre le traitement oral par les ICI simultanément à un traitement insecticide du milieu environnant et de l'animal. [Shipstone, M. A., Mason, K. V. The use of Insect Development Inhibitors as an oral medication for the control of the fleas Ctenocephalides felis, Ct. canis in the dog and cat (Utilisation d'inhibiteurs de croissance des insectes sous forme orale pour le contrôle des puces Ctenocephalides felis, Ct. canis chez le chien et le chat). Resumen—Existen dos inhibidores del desarrollo de insectos (ICI) para el control de pulgas. El Lefenuron se administra una vez al mes a una dosis de 10 mg × Kg‐1 en perros y 30 mg × Kg‐1 en gatos. La Ciromacina se administra diariamente a una dosis de 10 mg × Kg‐1 en combinación con citrato de dietilcarbamacina en perros. Ninguno de estos compuestos produce efecto en pulgas adultas, sino que causa una interrupción en la producción normal de quitina por distintos mecanismos de acción. Ello causa la muerte del parásito en estadíos de inmadurez y crecimiento. Así, ambos controlan la infestación por pulgas adultas en el animal mediante la eliminación de estadíos vitales de la pulga. Existe un espacio de tiempo de 6–8 semanas entre el inicio de la aministración de ICA y la reducción del número de pulgas en animales tratados. Ésto et debido a la supervivencia de pulgas inmaduras que se encontraban en el entorno antes del inicio del tratamiento con ICI; este periodo de tiempo se puede reducir iniciando el tratamiento oral con ICI junto con tratamiento insecticida de la vivienda y sobre el animal. [Shipstone, M. A., Mason, K. V. The use of Insect Development Inhibitors as an oral medication for the control of the fleas Ctenocephalides felis, Ct. canis in the dog and cat (El uso de inhibidores del desarrollo de insectos como medicación oral para el control de las pulgas Cenocephalides felis y Ct. canis en el perro y en el gato). Abstract—There are two oral Insect Development Inhibitors (IDI) for the control of fleas. Lufenuron is administered once a month at 10 mg × kg‐1 for dogs and 30 mg × kg‐1 for cats. Cyromazine is administered daily at 10 mg kg‐1 in combination with diethylcarbamazine citrate for dogs. Neither compound exerts an effect on the adult flea, but rather causes an interruption in normal chitin production through different specific modes of action. This causes death of the immature, developmental life stages of the flea. Thus, both control the adult flea infestation on the animal via the elimination of the environmental life stages of the flea. There is a lag phase of 6–8 weeks between the initiation of IDI administration and reduction in the number of adult fleas on the treated animals. The lag phase results from the survival of immature fleas that were present in the environment before the onset of IDI treatment; it can be reduced by initiating oral IDI treatment in combination with premise and on‐animal insecticide treatments.
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Lufenuron has ovicidal and larvicidal activity but no adulticidal effect.
“Lufenuron has ovicidal and larvicidal activity but no adulticidal effect [125,126].”
From Fleas infesting pets in the era of emerging extra-intestinal nematodes (2013) · cites this paper as [126]
Cites
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An examination of cuticle chitin and protein in cyromazine-affected Manduca sexta larvae
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THE BIOLOGY, ECOLOGY, AND MANAGEMENT OF THE CAT FLEA
Rust, M. K., & Dryden, M. W. (1997) · Annual Review of Entomology · doi:10.1146/annurev.ento.42.1.451 · Cited by 329 · see citing works
Fleas infesting pets in the era of emerging extra-intestinal nematodes
Traversa, D. (2013) · Parasites & Vectors · doi:10.1186/1756-3305-6-59 · Cited by 53 · see citing works
Ritzhaupt, L. K., Rowan, T. G., Jones, R. L., Cracknell, V. C., Murphy, M. G., & Shanks, D. J. (2002) · Veterinary Parasitology · doi:10.1016/s0304-4017(02)00051-1 · Cited by 17 · see citing works
- Authors
- SHIPSTONE, M. A., & MASON, K. V.
- Corresponding author
- SHIPSTONE, MICHAEL A.
- ORCID
- MASON, KENNETH V.
- Venue
- Veterinary Dermatology
- Publisher
- Wiley
- Published
- 1995-09
- Volume
- 6
- Issue
- 3
- Pages
- 131-137
- ISSN
- 0959-4493 (ISSN-L)
- 1365-3164
- OpenAlex
- W2117454768
- Cited by
- 21
- References
- 9
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2013: 1 · 2012: 2
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Veterinary Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Dermatological diseases and infestations
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
- Keywords
- insect growth regulators, flea control, Ctenocephalides felis, Ctenocephalides canis, lufenuron, cyromazine, diethylcarbamazine, chitin synthesis inhibition, flea infestation, dogs, cats, treatment delay, pyrethroid resistance
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