Efficacy dosage titration of lufenuron against developmental stages of fleas (Ctenocephalides felis felis) in cats
Abstract
Summary: Thirty-two mixed-breed male and female cats were blocked by sex, arranged by body weight from greatest to least, and allocated to 4 groups of 8 (4 male, 4 female) cats, using random numbers. Cats in each of 3 groups were treated orally with a 7% suspension formulation of lufenuron at dosage of 15, 30, or 45 mg/kg of body weight. Cats in the fourth group were treated orally with an excipient suspension without lufenuron. Cats were infested with newly emerged, unfed cat fleas (Ctenocephalides felis felis) on days - 7 and — 3 before treatment and at approximately weekly intervals after treatment. Flea eggs were collected from beneath each cat on selected days before and after treatment and placed in an artificial rearing medium. Flea eggs and medium were kept for 35 days in an insectary to determine effects of lufenuron or excipient suspension on emergence of adults of the F 1 generation. Lufenuron was 100% effective in inhibiting development of C felis at all dosages for 11 days after treatment. Thereafter, efficacy exceeded 92% in all dosages groups. On day 32, when the study was terminated, efficacy for each of the dosage groups was: 15 mg/kg, 95.2%; 30 mg/ kg, 98.2%; and 45 mg/kg, 99.6%. Adverse reactions or side effects were not observed in cats, regardless of treatment dosage.
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In the case of survival of fleas to an adulticide, and consequent production of eggs, IGRs may ultimately prevent the development of larvae.
“In the case of survival of fleas to an adulticide, and consequent production of eggs, IGRs may ultimately prevent the development of larvae [104,175].”
From Fleas infesting pets in the era of emerging extra-intestinal nematodes (2013) · cites this paper as [175]
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“High preventative efficacy lasting for about one month after a single treatment and proportionally longer after repeated treatments has been shown in vivo after oral administration to experimentally infested dogs [20, 113, 114, 138, 220, 267] and cats [21, 22, 108, 220].”
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“production of eggs, IGRs may ultimately prevent the development of larvae [104,175].”
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“A single oral dosage of lufenuron prevents hatching of eggs laid by ßeas for at least 30 d in dogs (Hink et al. 1994) and cats (Zakson et al. 1992, Blagburn et al. 1994), therebymakingmonthly treatments feasible for pets.”
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- Authors
- Blagbum, B. L., Vaughan, J. L., Lindsay, D. S., & Tebbitt, G. L.
- Affiliations
- Auburn University (US)
- From the Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL 36849-5519 (Blagburn, Vaughan, Lindsay), and CIBA Animal Health, Greensboro, NC 27419 (Tebbit).
- ORCID
- Lindsay, David S.
- Venue
- American Journal of Veterinary Research
- Published
- 1994-01-01
- Volume
- 55
- Issue
- 1
- Pages
- 98-101
- ISSN
- 0002-9645 (ISSN-L)
- OpenAlex
- W2396355899
- Cited by
- 35
- References
- 0
- Citations by year
- 2026: 1 · 2023: 1 · 2020: 1 · 2019: 1 · 2016: 1 · 2013: 1 · 2012: 2
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Veterinary Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Dermatological diseases and infestations
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Yersinia bacterium, plague, ectoparasites research
- Keywords
- lufenuron, Ctenocephalides felis, Ctenocephalides felis felis, flea control, dose titration, cats, oral suspension, efficacy, adverse effects
- MeSH terms
- Administration, Oral, Animals, Benzamides, Cat Diseases, Cats, Female, Siphonaptera, Fluorocarbons, Insecticides, Male, Oviposition, Parasitic Diseases, Parasitic Diseases, Animal
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