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Cited by 17Dermatological diseases and infestationsHelminth infection and controlVector-borne infectious diseases

Evaluation of the comparative efficacy of selamectin against flea (Ctenocephalides felis felis) infestations on dogs and cats in simulated home environments

Ritzhaupt, L.K., Rowan, T.G., Jones, R.L., Cracknell, V.C., Murphy, M.G., Shanks, D.J.·2002·Veterinary Parasitology
DOI 10.1016/s0304-4017(02)00051-1
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Abstract

The comparative efficacy of monthly administration of selamectin or lufenuron against Ctenocephalides felis felis on dogs and cats was evaluated over a 5-month period in flea-infested environments. Twenty-four dogs and 32 cats were randomly allocated to receiving a topical treatment with selamectin or an oral administration of tablets containing lufenuron/milbemycin oxime (for dogs) or lufenuron only (for cats). Each product was administered in accordance with the manufacturer's label recommendations. Eight dogs and four cats served as untreated sentinels. Treatments were administered on days 0, 30, 60, 90, and 120. Each animal received an application of 100 fleas on days -28 and -21, and then weekly applications of 20 fleas from days 91 through 147. Flea comb counts were performed on day -6, and every 2 weeks after day 0. From day 29 (dogs) or day 44 (cats) to day 150, geometric mean flea counts for selamectin were < or =0.4. Mean flea counts for animals assigned to treatment with selamectin were significantly lower (P=0.0001) than for animals assigned to treatment with lufenuron at all assessments after day 0.

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Crossref · 10.1016/s0304-4017(02)00051-1

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17 of 17 references verified0 citation errors · 0 not checkable

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  • Different products (e.g. imidacloprid, spinosad, selamectin) have excellent activity in killing existing adult fleas on pets.

    “Indeed, different products (e.g. imidacloprid, spinosad, selamectin) have an excellent activity in killing existing adult fleas on pets [104,105,114,133,172,173,176-178].”

    From Fleas infesting pets in the era of emerging extra-intestinal nematodes (2013) · cites this paper as [177]

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Authors
Ritzhaupt, L. K., Rowan, T. G., Jones, R. L., Cracknell, V. C., Murphy, M. G., & Shanks, D. J.
Affiliations
  • Pfizer (United States) (US)
  • Pfizer (United Kingdom) (GB)
Corresponding author
Ritzhaupt, L.K.
ORCID
Venue
Veterinary Parasitology
Publisher
Elsevier BV
Published
2002-06
Volume
106
Issue
2
Pages
165-175
ISSN
0304-4017 (ISSN-L)
DOI
10.1016/s0304-4017(02)00051-1
OpenAlex
W2052147115
Cited by
17
References
17
Citations by year
2022: 1 · 2021: 2 · 2020: 3 · 2018: 2 · 2017: 2 · 2016: 1 · 2013: 2 · 2012: 1
FWCI
0.44
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Veterinary Parasitology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Dermatological diseases and infestations
  • Health Sciences › Veterinary › Small Animals › Helminth infection and control
  • Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
Keywords
selamectin, lufenuron, Ctenocephalides felis felis, fleas, dogs, cats, flea control, topical treatment, oral tablets, milbemycin oxime, drug efficacy comparison
MeSH terms
Animals, Antiparasitic Agents, Benzamides, Cat Diseases, Cats, Dog Diseases, Dogs, Drug Administration Schedule, Ectoparasitic Infestations, Female, Siphonaptera, Fluorocarbons, Housing, Animal, Insecticides, Ivermectin, Male, Treatment Outcome

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