The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
The Human Gene FALL39 and Processing of the Cathelin Precursor to the Antibacterial Peptide LL‐37 in Granulocytes
Abstract
The peptide FA‐LL‐37, previously termed FALL‐39, was originally predicted from an ORF of a cDNA clone isolated from a human bone marrow library. This peptide was synthesized and found to have antibacterial activity. We have now characterized and sequenced the complete gene for FA‐LL‐37, termed FALL39. It is a compact gene of 1963 bp with four exons. Exons 1–3 code for a signal sequence and the cathelin region. Exon 4 contains the information for the mature antibacterial peptide. Our results indicate that FALL39 is the only member of the cathelin gene family present in the human genome. Potential binding sites for acute‐phase‐response factors are identified in the promoter and in intron 2. A possible role for the cytokine interleukin‐6 in the regulation of FALL39 is discussed. Anti‐(FA‐LL‐37) IgG located the peptide in granulocytes and we isolated the mature peptide from these cells after degranulation. Structural analysis determined the mature peptide to be LL‐37. To obtain LL‐37 for antibacterial assays, synthetic FA‐LL‐37 was degraded with dipeptidyl‐peptidase I. This analysis showed that mature LL‐37 is a potent antibacterial peptide.
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Granules of the Human Neutrophilic Polymorphonuclear Leukocyte
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Innate antimicrobial peptide protects the skin from invasive bacterial infection
Nizet, V., Ohtake, T., Lauth, X., Trowbridge, J., Rudisill, J., Dorschner, R. A., Pestonjamasp, V., Piraino, J., Huttner, K., & Gallo, R. L. (2001) · Nature · doi:10.1038/35106587 · Cited by 1,198
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Metadata
- Authors
- Gudmundsson, G. H., Agerberth, B., Odeberg, J., Bergman, T., Olsson, B., & Salcedo, R.
- Venue
- European Journal of Biochemistry
- Publisher
- Wiley
- Published
- 1996-06
- Volume
- 238
- Issue
- 2
- Pages
- 325-332
- ISSN
- 0014-2956 (ISSN-L)
- 1432-1033
- OpenAlex
- W2126516803
- Cited by
- 578
- References
- 26
- FWCI
- 11.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Human Gene FALL39 and Processing of the Cathelin Precursor to the Antibacterial Peptide LL‐37 in Granulocytes. https://app.cochat.ai/papers/10.1111/j.1432-1033.1996.0325z.x
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- Gudmundsson, G. H., Agerberth, B., Odeberg, J., Bergman, T., Olsson, B., & Salcedo, R. (1996). The Human Gene FALL39 and Processing of the Cathelin Precursor to the Antibacterial Peptide LL‐37 in Granulocytes. European Journal of Biochemistry. https://doi.org/10.1111/j.1432-1033.1996.0325z.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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