The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Role of extracellular signal regulated kinases 1 and 2 in neuronal survival
Open accessAbstract
Extracellular signal regulated kinases 1 and 2 (ERK1/2) regulate cellular responses to a variety of extracellular stimuli. In the nervous system, ERK1/2 is critical for neuronal differentiation, plasticity and may also modulate neuronal survival. In this minireview, we present evidence that supports prosurvival activity of ERK1/2 in neurons. Several reports suggest that ERK1/2 mediates neuroprotective activity of extracellular factors, including neurotrophins. In addition, ERK1/2 is activated by neuronal injury. In damaged cells, ERK1/2 activation may act as a defensive mechanism that helps to compensate for the deleterious effects of a damaging insult. The emerging mechanisms of ERK1/2‐mediated neuroprotection may involve transcriptional regulation and/or direct inhibition of cell death machinery.
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Cites
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Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
Hardingham, G. E., Fukunaga, Y., & Bading, H. (2002) · Nature Neuroscience · doi:10.1038/nn835 · Cited by 1,686
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions
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Cited by
Spritzer, M. D., & Galea, L. A. M. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20457 · Cited by 277
Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress
Dagda, R. K., Zhu, J., Kulich, S. M., & Chu, C. T. (2008) · Autophagy · doi:10.4161/auto.6458 · Cited by 271
NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation
Amadoro, G., Ciotti, M. T., Costanzi, M., Cestari, V., Calissano, P., & Canu, N. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511065103 · Cited by 243
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Metadata
- Authors
- Hetman, M., & Gozdz, A.
- Venue
- European Journal of Biochemistry
- Publisher
- Wiley
- Published
- 2004-05-17
- Volume
- 271
- Issue
- 11
- Pages
- 2050-2055
- ISSN
- 0014-2956 (ISSN-L)
- 1432-1033
- OpenAlex
- W1529774113
- Cited by
- 274
- References
- 53
- FWCI
- 7.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
