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Cited by 14Antifungal resistance and susceptibilityFungal Infections and StudiesInfectious Diseases and Mycology

In vitro interaction between suramin and fluvastatin against clinically important Zygomycetes

Galgóczy, László, Papp, Tamás, Vágvölgyi, Csaba·2009·Mycoses
DOI 10.1111/j.1439-0507.2008.01634.x
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Abstract

Summary: The in vitro antifungal activity of suramin and its combinations with fluvastatin was investigated in this study. Several species belonging to the class Zygomycetes are considered agents of opportunistic human or animal infections. In the present work, 15 fungal isolates representing eight clinically important genera (Absidia, Micromucor, Mortierella, Mucor, Rhizomucor, Rhizopus, Saksenaea and Syncephalastrum) were investigated. The efficiency with which fluvastatin inhibited growth in the presence of suramin (100 μg ml−1) was studied. The investigated compounds acted synergistically and additively on the growth when a strain was resistant to suramin and sensitive to fluvastatin; at the same time, antagonistic interactions were detected when strains were sensitive to both agents. In these cases, the growth inhibition effect of suramin was dominant.

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Crossref · 10.1111/j.1439-0507.2008.01634.x

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  • An antifungal peptide secreted by Penicillium chrsyogenum (PAF) and suramin can decrease growth of zygomyceteous fungal species in the presence of different statins.

    “An antifungal peptide secreted by Penicillium chrsyogenum (Penicillium chrsyogenum antifungal protein; PAF) and a hexasulfonated naphtylurea, suramin (originally applied as an agent for treatment of parasitic infections) can decrease the growth of zygomyceteous fungal species in the presence of different statins [34,35] .”

    From Statins as antifungal agents (2011) · cites this paper as [35]

  • Interactions were not detected between FLV and suramin if the strain was insensitive to both compounds, but synergistic and additive interactions were observed if the fungus was sensitive to FLV and insensitive to suramin; antagonistic interaction was observed if the fungus was sensitive to both drugs.

    “Interactions were not detected between FLV and suramin if the investigated strain proved to be insensitive to both compounds, but synergistic and additive interactions could be observed if the fungus was sensitive to FLV and insensitive to suramin.Antagonistic interaction was observed if the fungus was sensitive to both drugs [35] .”

    From Statins as antifungal agents (2011) · cites this paper as [35]

  • Drug interactions were revealed between statins and nonantifungal drugs that have secondary antifungal activity.

    “Drug interactions were revealed between statins and nonantifungal drugs, which have a secondary antifungal activity.”

    From Statins as antifungal agents (2011) · cites this paper as [35]

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Authors
Galgóczy, L., Papp, T., & Vágvölgyi, C.
Affiliations
University of Szeged (HU)
Corresponding author
Galgóczy, László
ORCID
Venue
Mycoses
Publisher
Wiley
Published
2009-07-29
Volume
52
Issue
5
Pages
447-453
ISSN
  • 0027-5557 (ISSN-L)
  • 0933-7407
  • 1439-0507
DOI
10.1111/j.1439-0507.2008.01634.x
OpenAlex
W1974626922
Cited by
14
References
29
Citations by year
2025: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2015: 1 · 2013: 1
FWCI
1.83
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Mycoses (publishedVersion)
  • PubMed (publishedVersion)
Funders
Magyar Tudományos Akadémia
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
  • Health Sciences › Veterinary › Small Animals › Infectious Diseases and Mycology
Keywords
suramin, fluvastatin, Zygomycetes, combination antifungal therapy, drug interactions, synergistic interaction, antagonism, Mucorales, opportunistic fungal infection, Mucor, Rhizopus, Syncephalastrum, drug resistance
MeSH terms
Fluvastatin, Animals, Antifungal Agents, Drug Interactions, Fatty Acids, Monounsaturated, Fungi, Humans, Indoles, Microbial Sensitivity Tests, Suramin

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