Interactions between statins and Penicillium chrysogenum antifungal protein (PAF) to inhibit the germination of sporangiospores of different sensitive Zygomycetes
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This study reports on the antifungal activities of statins combined with an antifungal compound secreted by Penicillium chrysogenum, PAF. Several species belonging in the class Zygomycetes are considered to be agents of human or animal mycoses; other species have significance as postharvest plant pathogens. In the present work, four species (Rhizopus stolonifer, Mortierella wolfii, Syncephalastrum racemosum and Mycotypha africana) that exhibited different sensitivities to lovastatin and PAF in previous experiments were investigated. The efficiencies with which four statins (lovastatin, simvastatin, rosuvastatin and atorvastatin) inhibited sporangiospore germination in the absence or in the presence of a constant concentration of PAF were studied. PAF and lovastatin acted synergistically on the sporangiospore germination of Mycotypha africana, and similar effects of the combinations PAF-rosuvastatin and PAF-atorvastatin were observed on S. racemosum.
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The activities of statin-PAF combinations varied and depended on the activities of the components applied separately; when a strain was resistant to one component, significant interactions could not be detected, and when sensitive to both, synergistic or additive interactions were detected.
“The activities of the statin-PAF combinations on the different strains varied, and depended on the activities of the components applied separately.When a strain was resistant to one of the components, significant interactions could not be detected.On the other hand, when a strain was sensitive to both types of antifungal agents, synergistic or additive interactions were detected [34] .”
From Statins as antifungal agents (2011) · cites this paper as [34]
An antifungal peptide secreted by Penicillium chrsyogenum (PAF) and suramin can decrease growth of zygomyceteous fungal species in the presence of different statins.
“An antifungal peptide secreted by Penicillium chrsyogenum (Penicillium chrsyogenum antifungal protein; PAF) and a hexasulfonated naphtylurea, suramin (originally applied as an agent for treatment of parasitic infections) can decrease the growth of zygomyceteous fungal species in the presence of different statins [34,35] .”
From Statins as antifungal agents (2011) · cites this paper as [34]
Drug interactions were revealed between statins and nonantifungal drugs that have secondary antifungal activity.
“Drug interactions were revealed between statins and nonantifungal drugs, which have a secondary antifungal activity.”
From Statins as antifungal agents (2011) · cites this paper as [34]
Differences in effectiveness among statins have been correlated with structural divergences that may influence interaction with the catalytic site of HMG-CoA reductase.
“Likewise, differences on the effectiveness among statins have been correlated to structural divergences, which may influence the interaction with the catalytic site of HMG-CoA reductase.13”
An IR of 0.5-1.5 means additivity, below 0.5 means antagonism, and above 1.5 means synergism.
“IR values between 0.5 and 1.5 correspond to additive interactions, IR < 0.5 indicates antagonism and IR > 1.5 denotes synergism.13”
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- Authors
- Galgóczy, L., Papp, T., Lukács, G., Leiter, Ã., Pócsi, I., & Vágvölgyi, C.
- Affiliations
- University of Szeged (HU)
- University of Debrecen (HU)
- Venue
- FEMS Microbiology Letters
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-05
- Volume
- 270
- Issue
- 1
- Pages
- 109-115
- ISSN
- 0378-1097 (ISSN-L)
- 1574-6968
- OpenAlex
- W1866310169
- Cited by
- 37
- References
- 25
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2016: 1 · 2014: 1 · 2013: 3 · 2012: 4
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- FEMS Microbiology Letters (publishedVersion)
- PubMed (publishedVersion)
- University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion, other-oa)
- Funders
- Core Research for Evolutional Science and Technology
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Keywords
- statins, Penicillium chrysogenum, antifungal proteins, PAF, Zygomycetes, sporangiospore germination, lovastatin, simvastatin, rosuvastatin, atorvastatin, antifungal synergy, Rhizopus stolonifer, Syncephalastrum racemosum, fungal infection
- MeSH terms
- Rosuvastatin Calcium, Atorvastatin, Antifungal Agents, Dose-Response Relationship, Drug, Drug Synergism, Fluorobenzenes, Fungi, Heptanoic Acids, Lovastatin, Microbial Sensitivity Tests, Penicillium chrysogenum, Pyrimidines, Pyrroles, Spores, Fungal, Sulfonamides, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Simvastatin
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