Cholesterol-independent Effects of Statins and New Therapeutic Targets: Ischemic Stroke and Dementia
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The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, or "statins", are used as cholesterol-lowering agents worldwide. Statins inhibit cholesterol biosynthesis, leading to enhanced uptake of low-density lipoprotein (LDL) from the circulation via LDL receptors. This strong cholesterol-lowering action contributes to the beneficial effects of statins. For example, large clinical trials have demonstrated that statins significantly reduce cardiovascular risk. Recent research has shown that statins have other multiple actions involved in endothelial function, cell proliferation, inflammatory response, immunological reactions, platelet function, and lipid oxidation. These "pleiotropic actions" of statins probably provide a significant contribution to the reduction of cardiovascular events. This review summarizes the pleiotropic actions of statins in both basic and clinical studies. It also considers the potential for statin therapy in the treatment of stroke and dementia.
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Statins induce apoptosis-like cell death in filamentous fungi.
“Beyond to the harmful effects on membrane fluidity and the synthesis of important isoprenoids for cell signaling and vital processes (such as cell proliferation and differentiation), and protein prenylation [16] , statins induce apoptosis-like cell death in filamentous fungi [15,30,31] .”
From Statins as antifungal agents (2011) · cites this paper as [30]
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Statins and Myasthenia Gravis: Clinical Implications and Pathogenesis
Tian, X., & Zhang, P. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27188150
- Authors
- Miida, T., Hirayama, S., & Nakamura, Y.
- Affiliations
- Niigata University (JP)
- Venue
- Journal of Atherosclerosis and Thrombosis
- Publisher
- Japan Atherosclerosis Society
- Published
- 2004
- Volume
- 11
- Issue
- 5
- Pages
- 253-264
- ISSN
- 1340-3478 (ISSN-L)
- 1880-3873
- OpenAlex
- W2069227492
- Cited by
- 97
- References
- 98
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 7 · 2013: 4 · 2012: 5
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Journal of Atherosclerosis and Thrombosis (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- statins, pleiotropy, ischemic stroke, dementia, endothelial function, inflammation, platelet function, lipid oxidation, cardiovascular risk reduction
- MeSH terms
- Brain Ischemia, Cholesterol, Dementia, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Stroke
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