Cited by 97Lipoproteins and Cardiovascular HealthCancer, Lipids, and MetabolismCholesterol and Lipid Metabolism

Cholesterol-independent Effects of Statins and New Therapeutic Targets: Ischemic Stroke and Dementia

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Miida, Takashi, Hirayama, Satoshi, Nakamura, Yuichi·2004·Journal of Atherosclerosis and Thrombosis

Abstract

The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, or "statins", are used as cholesterol-lowering agents worldwide. Statins inhibit cholesterol biosynthesis, leading to enhanced uptake of low-density lipoprotein (LDL) from the circulation via LDL receptors. This strong cholesterol-lowering action contributes to the beneficial effects of statins. For example, large clinical trials have demonstrated that statins significantly reduce cardiovascular risk. Recent research has shown that statins have other multiple actions involved in endothelial function, cell proliferation, inflammatory response, immunological reactions, platelet function, and lipid oxidation. These "pleiotropic actions" of statins probably provide a significant contribution to the reduction of cardiovascular events. This review summarizes the pleiotropic actions of statins in both basic and clinical studies. It also considers the potential for statin therapy in the treatment of stroke and dementia.

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  • Statins induce apoptosis-like cell death in filamentous fungi.

    “Beyond to the harmful effects on membrane fluidity and the synthesis of important isoprenoids for cell signaling and vital processes (such as cell proliferation and differentiation), and protein prenylation [16] , statins induce apoptosis-like cell death in filamentous fungi [15,30,31] .”

    From Statins as antifungal agents (2011) · cites this paper as [30]

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Authors
Miida, T., Hirayama, S., & Nakamura, Y.
Affiliations
Niigata University (JP)
Venue
Journal of Atherosclerosis and Thrombosis
Published
2004
Volume
11
Issue
5
Pages
253-264
ISSN
  • 1340-3478 (ISSN-L)
  • 1880-3873
OpenAlex
W2069227492
Cited by
97
References
98
Citations by year
2026: 1 · 2025: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 7 · 2013: 4 · 2012: 5
FWCI
2.10
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • Journal of Atherosclerosis and Thrombosis (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Keywords
statins, pleiotropy, ischemic stroke, dementia, endothelial function, inflammation, platelet function, lipid oxidation, cardiovascular risk reduction
MeSH terms
Brain Ischemia, Cholesterol, Dementia, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Stroke

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