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Cited by 89Cardiovascular and exercise physiologyCardiovascular Effects of ExerciseSports Performance and Training

Cardiovascular adaptations in rats submitted to a resistance-training model

Barauna, Valerio G, Junior, Miguel Luis B, Costa Rosa, Luis Fernando BP, Casarini, Dulce E, Krieger, José Eduardo, Oliveira, Edilamar M·2005·Clinical and Experimental Pharmacology and Physiology
DOI 10.1111/j.1440-1681.2005.04180.x
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Abstract

1. The present study sought to evaluate cardiovascular adaptations, such as blood pressure (BP), heart rate (HR) and cardiac hypertrophy, to resistance training (RT) in a rat model. 2. The training protocol consisted of four sets of 10-12 repetitions of the squat exercise performed at 65-75% of one repetition maximum (1RM) over 4 weeks. Animals were randomly divided into three groups: control (n = 8, CO), electrically stimulated (n = 8, ES) and trained (n = 8, TR; also electrically stimulated). Blood pressure and HR were measured by a direct method in conscious rats after the training period. 3. All groups began with similar 1RM and 1RM/bodyweight (BW) ratio, however, at the end of the protocol only the TR group was different from the beginning (56% and 50%, respectively; both P < 0.01). The CO and ES groups had similar values for cardiac chambers weight/BW ratio, HR and diastolic, systolic and mean BP. Left ventricular hypertrophy (LVH) determined by the left ventricle (LV) weight/BW ratio was increased in the TR group (12%) when compared to CO (P < 0.01) or ES groups (P < 0.01). No changes were found in the weights of the atrium or right ventricle. Diastolic (14%) and mean BP (13%) were lower in the TR group (P < 0.05), whereas systolic BP and HR remained unchanged. 4. Collectively these results demonstrate that the rat RT model used is associated with significant development of cardiac hypertrophy and lowering of resting BP. These cardiovascular adaptations seem to a result of the training exercise and not influenced by stress since circulating catecholamine levels and adrenal gland weights remained unchanged in all groups.

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Authors
Barauna, V. G., Junior, M. L. B., Costa Rosa, L. F. B., Casarini, D. E., Krieger, J. E., & Oliveira, E. M.
Affiliations
  • Universidade Federal de São Paulo (BR)
  • Universidade de São Paulo (BR)
Corresponding author
Oliveira, Edilamar M
ORCID
Venue
Clinical and Experimental Pharmacology and Physiology
Publisher
Wiley
Published
2005-03-30
Volume
32
Issue
4
Pages
249-254
ISSN
  • 0305-1870 (ISSN-L)
  • 1440-1681
DOI
10.1111/j.1440-1681.2005.04180.x
OpenAlex
W1997024683
Cited by
89
References
49
Citations by year
2025: 3 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 7 · 2017: 9 · 2016: 9 · 2015: 4 · 2014: 6 · 2013: 7 · 2012: 4
FWCI
6.42
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Clinical and Experimental Pharmacology and Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords
resistance training, cardiovascular adaptation, cardiac hypertrophy, left ventricular hypertrophy, blood pressure, heart rate, squatting, electrical stimulation, rat model, catecholamines, adrenal gland
MeSH terms
Adrenal Glands, Animals, Blood Pressure, Body Weight, Cardiovascular Physiological Phenomena, Catecholamines, Electric Stimulation, Heart, Organ Size, Physical Conditioning, Animal, Random Allocation, Weight Lifting, Weight-Bearing, Rats, Wistar, Muscle, Skeletal, Models, Animal, Rats

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