PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation
Open accessAbstract
Excess lipid accumulation in the heart is associated with decreased cardiac function in humans and in animal models. The reasons are unclear, but this is generally believed to result from either toxic effects of intracellular lipids or excessive fatty acid oxidation (FAO). PPARγ expression is increased in the hearts of humans with metabolic syndrome, and use of PPARγ agonists is associated with heart failure. Here, mice with dilated cardiomyopathy due to cardiomyocyte PPARγ overexpression were crossed with PPARα-deficient mice. Surprisingly, this cross led to enhanced expression of several PPAR-regulated genes that mediate fatty acid (FA) uptake/oxidation and triacylglycerol (TAG) synthesis. Although FA oxidation and TAG droplet size were increased, heart function was preserved and survival improved. There was no marked decrease in cardiac levels of triglyceride or the potentially toxic lipids diacylglycerol (DAG) and ceramide. However, long-chain FA coenzyme A (LCCoA) levels were increased, and acylcarnitine content was decreased. Activation of PKCα and PKCδ, apoptosis, ROS levels, and evidence of endoplasmic reticulum stress were also reduced. Thus, partitioning of lipid to storage and oxidation can reverse cardiolipotoxicity despite increased DAG and ceramide levels, suggesting a role for other toxic intermediates such as acylcarnitines in the toxic effects of lipid accumulation in the heart.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The abnormal fatty acid levels create toxic byproducts that cause cell apoptosis, contributing to kidney failure.
“The abnormal fatty acid levels create toxic byproducts that cause cell apoptosis, contributing to kidney failure.”
From Associations of Fenofibrate Therapy With Incidence and Progression of CKD in Patients With Type 2 Diabetes (2019) · cites this paper as [25]
Patients with diabetic kidney disease have altered activity of lipid-metabolizing enzymes, which may lead to a reduction in fatty acid metabolism.
“Patients with diabetic kidney disease have altered activity of lipid-metabolizing enzymes, which may lead to a reduction in fatty acid metabolism.25”
From Associations of Fenofibrate Therapy With Incidence and Progression of CKD in Patients With Type 2 Diabetes (2019) · cites this paper as [25]
Cites
A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189 · see citing works
Echocardiographic assessment of left ventricular hypertrophy: Comparison to necropsy findings
Devereux, R. B., Alonso, D. R., Lutas, E. M., Gottlieb, G. J., Campo, E., Sachs, I., & Reichek, N. (1986) · The American Journal of Cardiology · doi:10.1016/0002-9149(86)90771-x · Cited by 6,226 · see citing works
Dormandy, J. A., Charbonnel, B., Eckland, D. J., Erdmann, E., Massi-Benedetti, M., Moules, I. K., Skene, A. M., Tan, M. H., Lefèbvre, P. J., Murray, G. D., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67528-9 · Cited by 4,129 · see citing works
Direct transesterification of all classes of lipids in a one-step reaction.
Lepage, G., & ROY, C. C. (1986) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38861-1 · Cited by 2,385 · see citing works
mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.Preprint
Tontonoz, P., Hu, E., Graves, R. A., Budavari, A. I., & Spiegelman, B. M. (1994) · Genes & Development · doi:10.1101/gad.8.10.1224 · Cited by 2,182 · see citing works
Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase
Zimmermann, R., Bogner‐Strauß, J. G., Haemmerle, G., Schoiswohl, G., Birner‐Gruenberger, R., Riederer, M., Lass, A., Neuberger, G., Eisenhaber, F., Hermetter, A., et al. (2004) · Science · doi:10.1126/science.1100747 · Cited by 2,121 · see citing works
Yu, C., Chen, Y., Cline, G. W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J. K., Cushman, S. W., Cooney, G. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200958200 · Cited by 1,561 · see citing works
Self-citationDiabetic Cardiomyopathy Revisited
Boudina, S., & Abel, E. D. (2007) · Circulation · doi:10.1161/circulationaha.106.679597 · Cited by 1,543 · see citing works
Self-citationLipotoxic heart disease in obese rats: Implications for human obesity
Zhou, Y.-T., Grayburn, P., Karim, A., Shimabukuro, M., Higa, M., Baetens, D., Orci, L., & Unger, R. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1784 · Cited by 1,265 · see citing works
Cases, S., Smith, S. J., Zheng, Y.-W., Myers, H. M., Lear, S. R., Sande, E., Novak, S., Collins, C. C., Welch, C. L., Lusis, A. J., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13018 · Cited by 1,124 · see citing works
Regulation of Muscle Fiber Type and Running Endurance by PPARδ
Wang, Y.-X., Zhang, C.-L., Yu, R. T., Cho, H. K., Nelson, M. C., Bayuga-Ocampo, C. R., Ham, J., Kang, H., & Evans, R. M. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020294 · Cited by 1,089 · see citing works
Leone, T. C., Weinheimer, C. J., & Kelly, D. P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7473 · Cited by 943 · see citing works
Lipotoxicity: when tissues overeat
Schaffer, J. E. (2003) · Current Opinion in Lipidology · doi:10.1097/00041433-200306000-00008 · Cited by 914 · see citing works
The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus
Finck, B. N., Lehman, J. J., Leone, T. C., Welch, M. J., Bennett, M. J., Kovács, A. D., Han, X., Gross, R. W., Kozak, R., Lopaschuk, G. D., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14080 · Cited by 887 · see citing works
Wilkinson, B. M., & Gilbert, H. (2004) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2004.02.017 · Cited by 881 · see citing works
Unger, R. H. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104057 · Cited by 875 · see citing works
Chawla, A., Schwarz, E. J., Dimaculangan, D. D., & Lazar, M. A. (1994) · Endocrinology · doi:10.1210/endo.135.2.8033830 · Cited by 874 · see citing works
A protocol for rapid generation of recombinant adenoviruses using the AdEasy system
Luo, J., Deng, Z.-L., Luo, X., Tang, N., Song, W.-X., Chen, J., Sharff, K. A., Luu, H. H., Haydon, R. C., Kinzler, K. W., et al. (2007) · Nature Protocols · doi:10.1038/nprot.2007.135 · Cited by 854 · see citing works
Thiazolidinedione Use, Fluid Retention, and Congestive Heart Failure
Nesto, R. W., Bell, D. S. H., Bonow, R. O., Fonseca, V. A., Grundy, S. M., Horton, E. S., Winter, M. L., Porte, D., Semenkovich, C. F., Smith, S. E., et al. (2003) · Circulation · doi:10.1161/01.cir.0000103683.99399.7e · Cited by 831 · see citing works
DNA damage responses to oxidative stress
Barzilai, A., & Yamamoto, K.-I. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.03.002 · Cited by 796 · see citing works
The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus
Finck, B. N., Lehman, J. J., Leone, T. C., Welch, M. J., Bennett, M. J., Kovács, A., Han, X., Gross, R. W., Kozak, R., Lopaschuk, G. D., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214080 · Cited by 765 · see citing works
A novel mouse model of lipotoxic cardiomyopathy
Chiu, H.-C., Kovács, A., Ford, D. A., Hsu, F., Garcia, R. A., Herrero, P., Saffitz, J. E., & Schaffer, J. E. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10947 · Cited by 762 · see citing works
Palmitate-induced Apoptosis Can Occur through a Ceramide-independent Pathway
Listenberger, L. L., Ory, D. S., & Schaffer, J. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010286200 · Cited by 594 · see citing works
Mitochondrial Energetics in the Heart in Obesity-Related Diabetes
Boudina, S., Sena, S., Theobald, H., Sheng, X., Wright, J. J., Hu, X. X., Aziz, S., Johnson, J. I., Bugger, H., Zaha, V. G., et al. (2007) · Diabetes · doi:10.2337/db07-0481 · Cited by 586 · see citing works
Self-citationPoornima, I. G., Parikh, P., & Shannon, R. P. (2006) · Circulation Research · doi:10.1161/01.res.0000207406.94146.c2 · Cited by 567 · see citing works
Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death
Borradaile, N. M., Han, X., Harp, J. D., Gale, S. E., Ory, D. S., & Schaffer, J. E. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600299-jlr200 · Cited by 564 · see citing works
Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the Liver
Monetti, M., Levin, M. C., Watt, M. J., Sajan, M. P., Marmor, S., Hubbard, B. K., Stevens, R. D., Bain, J. R., Newgard, C. B., Farese, R. V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.005 · Cited by 511 · see citing works
Finck, B. N., Han, X., Courtois, M., Aimond, F., Nerbonne, J. M., Kovacs, A., Gross, R. W., & Kelly, D. P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0336724100 · Cited by 501 · see citing works
Lipid accumulation in non-adipose tissue and lipotoxicity
van Herpen, N. A., & Schrauwen-Hinderling, V. B. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.11.049 · Cited by 500 · see citing works
Transgenic Expression of Fatty Acid Transport Protein 1 in the Heart Causes Lipotoxic Cardiomyopathy
Chiu, H.-C., Kovács, A. D., Blanton, R. M., Han, X., COURTOIS, M. R., Weinheimer, C. J., Yamada, K. A., Brunet, S., Xu, H., Nerbonne, J. M., et al. (2004) · Circulation Research · doi:10.1161/01.res.0000154079.20681.b9 · Cited by 467 · see citing works
Mazumder, P. K., O’Neill, B. T., Roberts, M. W., Buchanan, J., Yun, U. J., Cooksey, R. C., Boudina, S., & Abel, E. D. (2004) · Diabetes · doi:10.2337/diabetes.53.9.2366 · Cited by 437 · see citing works
Self-citationIdentification of PKC-isoform-specific biological actions using pharmacological approaches
Way, K. J., Chou, E. L., & King, G. L. (2000) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01468-1 · Cited by 436 · see citing works
Alterations in Lipoprotein Metabolism in Peroxisome Proliferator-activated Receptor α-deficient Mice
Peters, J. M., Hennuyer, N., Staels, B., Fruchart, J., Fiévet, C., Gonzalez, F. J., & Auwerx, J. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.43.27307 · Cited by 429 · see citing works
Ceramide is a cardiotoxin in lipotoxic cardiomyopathy
Park, T., Hu, Y., Noh, H. L., Drosatos, K., Okajima, K., Buchanan, J., Tuinei, J., Homma, S., Jiang, X.-C., Abel, E. D., et al. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800147-jlr200 · Cited by 412 · see citing works
Self-citationThe Subcellular Distribution of Carnitine Acyltransferases in Mammalian Liver and Kidney
Markwell, M. A. K., McGroarty, E. J., BIEBER, L. L., & Tolbert, N. E. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43946-x · Cited by 404 · see citing works
Yagyu, H., Chen, G., Yokoyama, M., Hirata, K., Augustus, A. S., Kako, Y., Seo, T., Hu, Y., Lutz, E. P., Merkel, M., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16751 · Cited by 394 · see citing works
Self-citationNishino, N., Tamori, Y., Tateya, S., Kawaguchi, T., Shibakusa, T., Mizunoya, W., Inoue, K., Kitazawa, R., Kitazawa, S., Matsuki, Y., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34090 · Cited by 388 · see citing works
Cidea is associated with lipid droplets and insulin sensitivity in humans
Puri, V., Ranjit, S., Konda, S., Nicoloro, S. M. C., Straubhaar, J., Chawla, A., Chouinard, M., Lin, C.-Y., Burkart, A., Corvera, S., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802063105 · Cited by 385 · see citing works
Cardiac Lipid Accumulation Associated with Diastolic Dysfunction in Obese Mice
Christoffersen, C., Bollano, E., Lindegaard, M. L. S., Bartels, E. D., Goetze, J. P., Andersen, C. B., & Nielsen, L. B. (2003) · Endocrinology · doi:10.1210/en.2003-0242 · Cited by 375 · see citing works
Miura, S., Gan, J.-W., Brzostowski, J. A., Parisi, M. J., Schultz, C. J., Londos, C., Oliver, B., & Kimmel, A. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204410200 · Cited by 372 · see citing works
Liu, L., Zhang, Y., Chen, N., Shi, X., Tsang, B., & Yu, Y.-H. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30565 · Cited by 356 · see citing works
Cardiomyocyte expression of PPARγ leads to cardiac dysfunction in mice
Son, N.-H., Park, T., Yamashita, H., Yokoyama, M., Huggins, L. A., Okajima, K., Homma, S., Szabolcs, M. J., Huang, L., & Goldberg, I. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30335 · Cited by 335 · see citing works
Self-citationOXPAT/PAT-1 Is a PPAR-Induced Lipid Droplet Protein That Promotes Fatty Acid Utilization
Wolins, N. E., Quaynor, B. K., Skinner, J. R., Tzekov, A., Croce, M. A., Gropler, M. C., Varma, V., Yao‐Borengasser, A., Rasouli, N., Kern, P. A., et al. (2006) · Diabetes · doi:10.2337/db06-0399 · Cited by 324 · see citing works
Zhang, H., Zhang, A., Kohan, D. E., Nelson, R. D., Gonzalez, F. J., & Yang, T. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501744102 · Cited by 316 · see citing works
Protein kinase C and the development of diabetic vascular complications
Way, K. J., Katai, N., & King, G. L. (2001) · Diabetic Medicine · doi:10.1046/j.0742-3071.2001.00638.x · Cited by 313 · see citing works
MYOCARDIAL METABOLISM OF FATTY ACIDS*
Ballard, F. B., Danforth, W. H., NÄGLE, S., & Bing, R. J. (1960) · Journal of Clinical Investigation · doi:10.1172/jci104088 · Cited by 313 · see citing works
Reid, B. N., Ables, G. P., Otlivanchik, O., Schoiswohl, G., Zechner, R., Blaner, W. S., Goldberg, I. J., Schwabe, R. F., Chua, S. C., & Huang, L.-S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800533200 · Cited by 307 · see citing works
Self-citationColeman, R., Lewin, T. M., Horn, C. G. V., & González-Baró, M. R. (2002) · Journal of Nutrition · doi:10.1093/jn/132.8.2123 · Cited by 303 · see citing works
Zhang, D., Liu, Z.-X., Choi, C. S., Tian, L., Kibbey, R., Dong, J., Cline, G. W., Wood, P. A., & Shulman, G. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707060104 · Cited by 291 · see citing works
Self-citationDiagnosis and interpretation of steatosis and steatohepatitis.
Burt, A. D., Mutton, A., & Day, C. (1998) · PubMed · Cited by 291 · see citing works
Nuclear receptors PPARβ/δ and PPARα direct distinct metabolic regulatory programs in the mouse heart
Burkart, E. M., Sambandam, N., Han, X., Gross, R. W., COURTOIS, M. R., Gierasch, C. M., Shoghi, K. I., Welch, M. J., & Kelly, D. P. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32578 · Cited by 279 · see citing works
Acyl-CoA inhibition of adenine nucleotide translocation in ischemic myocardium
Shug, A. L., Shrago, E., Bittar, N., Jd, F., & Koke, J. R. (1975) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1975.228.3.689 · Cited by 263 · see citing works
Cardiac mitochondrial damage and biogenesis in a chronic model of type 1 diabetes
Shen, X., Zheng, S., Thongboonkerd, V., Xu, M., Pierce, W. M., Klein, J. B., & Epstein, P. N. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00047.2004 · Cited by 258 · see citing works
Activation of endoplasmic reticulum stress response during the development of ischemic heart disease
Azfer, A., Niu, J., Rogers, L. M., Adamski, F. M., & Kolattukudy, P. E. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01378.2005 · Cited by 252 · see citing works
CD36 Deficiency Rescues Lipotoxic Cardiomyopathy
Yang, J., Sambandam, N., Han, X., Gross, R. W., Courtois, M., Kovacs, A., Febbraio, M., Finck, B. N., & Kelly, D. P. (2007) · Circulation Research · doi:10.1161/01.res.0000264104.25265.b6 · Cited by 246 · see citing works
DGAT1 Expression Increases Heart Triglyceride Content but Ameliorates Lipotoxicity
Liu, L., Shi, X., Bharadwaj, K. G., Ikeda, S., Yamashita, H., Yagyu, H., Schaffer, J. E., Yu, Y., & Goldberg, I. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.049817 · Cited by 240 · see citing works
Self-citationOxidative Stress Causes Heart Failure with Impaired Mitochondrial Respiration
Nojiri, H., Shimizu, T., Funakoshi, M., Yamaguchi, O., Zhou, H., Kawakami, S., Ohta, Y., Sami, M., Tachibana, T., Ishikawa, H., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602118200 · Cited by 230 · see citing works
The Essential Function of Protein-disulfide Isomerase Is to Unscramble Non-native Disulfide Bonds
Laboissière, M. C. A., Sturley, S. L., & Raines, R. T. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.47.28006 · Cited by 214 · see citing works
Coates, P. J., Nenutil, R., McGregor, A., Picksley, S. M., Crouch, D. H., Hall, P. A., & Wright, E. G. (2001) · Experimental Cell Research · doi:10.1006/excr.2001.5166 · Cited by 207 · see citing works
Prophylaxis of early ventricular fibrillation by inhibition of acylcarnitine accumulation.
Corr, P. B., Creer, M. H., Yamada, K. A., Saffitz, J. E., & Sobel, B. E. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113978 · Cited by 206 · see citing works
Energy Metabolism in the Hypertrophied Heart
Sambandam, N., Lopaschuk, G. D., Brownsey, R. W., & Allard, M. F. (2002) · Heart Failure Reviews · doi:10.1023/a:1015380609464 · Cited by 182 · see citing works
Protection of C. elegans from Anoxia by HYL-2 Ceramide Synthase
Menuz, V., Howell, K. S., Gentina, S., Epstein, S., Riezman, I., Fornallaz-Mulhauser, M., Hengartner, M. O., Gomez, M., Riezman, H., & Martinou, J. (2009) · Science · doi:10.1126/science.1168532 · Cited by 171 · see citing works
Myocardial lipid accumulation in patients with pressure-overloaded heart and metabolic syndrome
Marfella, R., Filippo, C. D., Portoghese, M., Barbieri, M., Ferraraccio, F., Siniscalchi, M., Cacciapuoti, F., Rossi, F., D’Amico, M., & Paolisso, G. (2009) · Journal of Lipid Research · doi:10.1194/jlr.p900032-jlr200 · Cited by 148 · see citing works
Heart Metabolic Disturbances in Cardiovascular Diseases
Carvajal, K., & Moreno‐Sánchez, R. (2003) · Archives of Medical Research · doi:10.1016/s0188-4409(03)00004-3 · Cited by 146 · see citing works
Duncan, J. G., Bharadwaj, K. G., Fong, J. L., Mitra, R., Sambandam, N., COURTOIS, M. R., Lavine, K. J., Goldberg, I. J., & Kelly, D. P. (2010) · Circulation · doi:10.1161/circulationaha.109.888735 · Cited by 121 · see citing works
Self-citationLaybutt, D. R., Schmitz‐Peiffer, C., Saha, A. K., Ruderman, N. B., Biden, T. J., & Kraegen, E. W. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.6.e1070 · Cited by 114 · see citing works
Cellular uncoupling induced by accumulation of long-chain acylcarnitine during ischemia.
Yamada, K. A., McHowat, J., Yan, G., Donahue, K., Peirick, J., Kléber, A. G., & Corr, P. B. (1994) · Circulation Research · doi:10.1161/01.res.74.1.83 · Cited by 102 · see citing works
Wu, J., & Corr, P. B. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.266.3.h1034 · Cited by 90 · see citing works
Quantitative Determination of Ceramide Using Diglyceride Kinase
Perry, D. K., Bielawska, A. E., & Hannun, Y. A. (2000) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(00)12897-6 · Cited by 85 · see citing works
Okere, I. C., Chess, D. J., McElfresh, T. A., Johnson, J., Rennison, J., Ernsberger, P., Hoit, B. D., Chandler, M. P., & Stanley, W. C. (2005) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2005.04272.x · Cited by 79 · see citing works
Long-Chain Acylcarnitine Induces Ca2+ Efflux from the Sarcoplasmic Reticulum
Yamada, K. A., Kanter, E. M., & Newatia, A. (2000) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200007000-00002 · Cited by 74 · see citing works
Seo, T., Al-Haideri, M. T., Treskova, E., Worgall, T. S., Kako, Y., Goldberg, I. J., & Deckelbaum, R. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910327199 · Cited by 74 · see citing works
Self-citationBaidyaroy, D., Brosch, G., Ahn, J., Graessle, S., Wegener, S., Tonukari, N. J., Caballero, O., Loidl, P., & Walton, J. D. (2001) · The Plant Cell · doi:10.1105/tpc.010168 · Cited by 70 · see citing works
Zizola, C. F., Schwartz, G. J., & Vogel, S. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90464.2008 · Cited by 60 · see citing works
Vikramadithyan, R. K., Hirata, K., Yagyu, H., Hu, Y., Augustus, A. S., Homma, S., & Goldberg, I. J. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.080259 · Cited by 59 · see citing works
Self-citationTreating ischemic heart disease by pharmacologically improving cardiac energy metabolism
Lopaschuk, G. D. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00532-3 · Cited by 56 · see citing works
Fluid retention mediated by renal PPARγ
Staels, B. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.08.001 · Cited by 49 · see citing works
Structural biology of the thioester-dependent degradation and synthesis of fatty acids
Bhaumik, P., Koski, M. K., Glumoff, T., Hiltunen, J. K., & Wierenga, R. K. (2005) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2005.10.010 · Cited by 43 · see citing works
Ceramides--Friend or Foe in Hypoxia?
Crowder, C. M. (2009) · Science · doi:10.1126/science.1173278 · Cited by 37 · see citing works
Faiola, B., Falls, J. G., Peterson, R. A., Bordelon, N. R., Brodie, T. A., Cummings, C. A., Romach, E. H., & Miller, R. T. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfn130 · Cited by 36 · see citing works
Baidyaroy, D. (2001) · The Plant Cell · doi:10.1105/tpc.13.7.1609 · Cited by 24 · see citing works
Vikramadithyan, R. K., Chakrabarti, R., Misra, P., Mamnoor, P., Kumar, S. K. B., Rao, C. S., Ghosh, A., Reddy, K. N., Uma, C., & Rajagopalan, R. (2000) · Metabolism · doi:10.1053/meta.2000.17734 · Cited by 22 · see citing works
Obesity and the Risk of Heart Failure
Taegtmeyer, H., & Wilson, C. R. (2002) · New England Journal of Medicine · doi:10.1056/nejm200212053472314 · Cited by 19 · see citing works
Poor lipid control in type-2 diabetics with and without ischemic heart disease
Akbar, D., Algamdi, A., & Hejazi, N. (2003) · Endocrine · doi:10.1385/endo:21:3:217 · Cited by 18 · see citing works
No Low-Fat Diet for the Failing Heart?
Taegtmeyer, H., & Ballal, K. (2006) · Circulation · doi:10.1161/circulationaha.106.659235 · Cited by 16 · see citing works
Marfella, R., Portoghese, M., Ferraraccio, F., Siniscalchi, M., Babieri, M., Filippo, C. D., D’Amico, M., Rossi, F., & Paolisso, G. (2009) · Heart · doi:10.1136/hrt.2009.165969 · Cited by 15 · see citing works
The prognosis for Type 2 diabetic patients with heart disease
Torffvit, O., & Agardh, C. (2000) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(00)00117-3 · Cited by 12 · see citing works
Varela, A., Dalamón, V., Testoni, G., Carregal, M., Cerruti, S., & Savino, E. A. (1999) · Archives of Physiology and Biochemistry · doi:10.1076/apab.107.1.22.4351 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dynamics and functions of lipid droplets
Olzmann, J. A., & Carvalho, P. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0085-z · Cited by 2,740 · see citing works
Mechanisms of physiological and pathological cardiac hypertrophy
Nakamura, M., & Sadoshima, J. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0007-y · Cited by 1,662 · see citing works
PPAR control of metabolism and cardiovascular functions
Montaigne, D., Butruille, L., & Staels, B. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00569-6 · Cited by 960 · see citing works
Molecular mechanisms of diabetic cardiomyopathy
Bugger, H., & Abel, E. D. (2014) · Diabetologia · doi:10.1007/s00125-014-3171-6 · Cited by 903 · see citing works
Self-citationNguyen, T. B., Louie, S. M., Daniele, J. R., Tran, Q., Dillin, A., Zoncu, R., Nomura, D. K., & Olzmann, J. A. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.06.003 · Cited by 610 · see citing works
Lipid Metabolism and Toxicity in the Heart
Goldberg, I. J., Trent, C. M., & Schulze, P. C. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.006 · Cited by 586 · see citing works
Self-citationBenhamed, F., Denechaud, P.-D., Lemoine, M., Robichon, C., Moldes, M., Bertrand-Michel, J., Ratziu, V., Serfaty, L., Housset, C., Capeau, J., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci41636 · Cited by 408 · see citing works
Lipid Use and Misuse by the Heart
Schulze, P. C., Drosatos, K., & Goldberg, I. J. (2016) · Circulation Research · doi:10.1161/circresaha.116.306842 · Cited by 358 · see citing works
Self-citationZhang, S., Peng, X., Yang, S., Li, X., Huang, M., Wei, S., Liu, J., He, G., Zheng, H., Yang, L., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04593-3 · Cited by 317 · see citing works
Chokshi, A. D., Drosatos, K., Cheema, F. H., Ji, R., Khawaja, T., Yu, S., Kato, T., Khan, R. S., Takayama, H., Knöll, R., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.060889 · Cited by 297 · see citing works
Self-citationTaegtmeyer, H., Young, M. E., Lopaschuk, G. D., Abel, E. D., Brunengraber, H., Darley-Usmar, V. M., Rosiers, C. D., Gerszten, R. E., Glatz, J. F. C., Griffin, J. L., et al. (2016) · Circulation Research · doi:10.1161/res.0000000000000097 · Cited by 283 · see citing works
Self-citationEngin, A. B. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_8 · Cited by 260 · see citing works
He, L., Kim, T., Long, Q., Liu, J., Wang, P., Zhou, Y., Ding, Y., PRASAIN, J. K., Wood, P. A., & Yang, Q. (2012) · Circulation · doi:10.1161/circulationaha.111.075978 · Cited by 225 · see citing works
Cardiac Lipotoxicity: Molecular Pathways and Therapeutic Implications
Drosatos, K., & Schulze, P. C. (2013) · Current Heart Failure Reports · doi:10.1007/s11897-013-0133-0 · Cited by 217 · see citing works
Pu, J., Yuan, A., Shan, P., Gao, E., Wang, X., Wang, Y., Lau, W. B., Koch, W. J., Ma, X., & He, B. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs011 · Cited by 200 · see citing works
Lipid metabolism and signaling in cardiac lipotoxicity
D’Souza, K., Nzirorera, C., & Kienesberger, P. C. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.02.016 · Cited by 190 · see citing works
Lipotoxicity in obesity and diabetes-related cardiac dysfunction
Zlobine, I., Gopal, K., & Ussher, J. R. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.02.011 · Cited by 170 · see citing works
The Evolving Understanding of the Contribution of Lipid Metabolism to Diabetic Kidney Disease
Stadler, K., Goldberg, I. J., & Susztak, K. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0611-8 · Cited by 165 · see citing works
Self-citationDrosatos, K., Khan, R. S., Trent, C. M., Jiang, H., Son, N.-H., Blaner, W. S., Homma, S., Schulze, P. C., & Goldberg, I. J. (2013) · Circulation Heart Failure · doi:10.1161/circheartfailure.112.000177 · Cited by 149 · see citing works
Self-citationMetabolic Modulators in Heart Disease: Past, Present, and Future
Lopaschuk, G. D. (2016) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2016.12.013 · Cited by 146 · see citing works
Manifestations and mechanisms of myocardial lipotoxicity in obesity
Sletten, A. C., Peterson, L. R., & Schaffer, J. E. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12728 · Cited by 142 · see citing works
Yang, D., Wang, W., Li, L., Peng, Y., Chen, P., Huang, H., Guo, Y., Xia, X., Wang, Y., Wang, H., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059020 · Cited by 138 · see citing works
Dietary Fat and Heart Failure: Moving From Lipotoxicity to Lipoprotection
Stanley, W. C., Dabkowski, E. R., Júnior, R. F. R., & O’Connell, K. A. (2012) · Circulation Research · doi:10.1161/circresaha.111.253104 · Cited by 131 · see citing works
High Fat Diet Upregulates Fatty Acid Oxidation and Ketogenesis via Intervention of PPAR-γ
Sikder, K., Shukla, S. K., Patel, N., Singh, H., & Rafiq, K. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000492091 · Cited by 133 · see citing works
Shao, Y., Redfors, B., Ståhlman, M., Täng, M. S., Miljanovic, A., Möllmann, H., Troidl, C., Szardien, S., Hamm, C. W., NEF, H. M., et al. (2012) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfs161 · Cited by 126 · see citing works
Rethinking pioglitazone as a cardioprotective agent: a new perspective on an overlooked drug
Nesti, L., Tricò, D., Mengozzi, A., & Natali, A. (2021) · Cardiovascular Diabetology · doi:10.1186/s12933-021-01294-7 · Cited by 125 · see citing works
Mechanisms of Lipotoxicity in the Cardiovascular System
Wende, A. R., Symons, J. D., & Abel, E. D. (2012) · Current Hypertension Reports · doi:10.1007/s11906-012-0307-2 · Cited by 119 · see citing works
Self-citationPCSK9 deficiency rewires heart metabolism and drives heart failure with preserved ejection fraction
Dalt, L. D., Castiglioni, L., Baragetti, A., Audano, M., Svecla, M., Bonacina, F., Pedretti, S., Uboldi, P., Benzoni, P., Giannetti, F., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab431 · Cited by 118 · see citing works
Zammit, V. A. (2013) · Biochemical Journal · doi:10.1042/bj20121689 · Cited by 115 · see citing works
Kienesberger, P. C., Pulinilkunnil, T., Sung, M. M. Y., Nagendran, J., Haemmerle, G., Kershaw, E. E., Young, M. E., Light, P. E., Oudit, G. Y., Zechner, R., et al. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.06470-11 · Cited by 111 · see citing works
New Molecular Insights of Insulin in Diabetic Cardiomyopathy
Westermeier, F., Riquelme, J. A., Pávez, M., Garrido, V., Díaz, A., Verdejo, H., Castro, P., Garcı́a, L., & Lavandero, S. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00125 · Cited by 111 · see citing works
Bosma, M., Dapito, D. H., Drosatos-Tampakaki, Z., Son, N. H., Huang, L., Kersten, S., Drosatos, K., & Goldberg, I. J. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.09.012 · Cited by 104 · see citing works
Self-citationAre targeted therapies for diabetic cardiomyopathy on the horizon?
Tate, M., Grieve, D., & Ritchie, R. H. (2017) · Clinical Science · doi:10.1042/cs20160491 · Cited by 95 · see citing works
Metabolism and Chronic Inflammation: The Links Between Chronic Heart Failure and Comorbidities
Li, Z., Zhao, H., & Wang, J. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.650278 · Cited by 98 · see citing works
Adipose Tissue Biology and Cardiomyopathy
Turer, A. T., Hill, J. A., Elmquist, J. K., & Scherer, P. E. (2012) · Circulation Research · doi:10.1161/circresaha.111.262493 · Cited by 89 · see citing works
The Mitochondria in Diabetic Heart Failure: From Pathogenesis to Therapeutic Promise
Schilling, J. D. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6294 · Cited by 90 · see citing works
CYP2J2-Derived Epoxyeicosatrienoic Acids Suppress Endoplasmic Reticulum Stress in Heart Failure
Wang, X., Ni, L., Yang, L., Duan, Q., Chen, C., Edin, M. L., Zeldin, D. C., & Wang, D. W. (2013) · Molecular Pharmacology · doi:10.1124/mol.113.087122 · Cited by 87 · see citing works
Bround, M. J., Wambolt, R., Luciani, D. S., Kulpa, J. E., Rodrigues, B. B., Brownsey, R. W., Allard, M. F., & Johnson, J. D. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.427062 · Cited by 82 · see citing works
Sphingolipids, Lipotoxic Cardiomyopathy, and Cardiac Failure
Park, T., & Goldberg, I. J. (2012) · Heart Failure Clinics · doi:10.1016/j.hfc.2012.06.003 · Cited by 82 · see citing works
Self-citationA Novel Function of MicroRNA 130a-3p in Hepatic Insulin Sensitivity and Liver Steatosis
Xiao, F., Yu, J., Liu, B., Guo, Y., Li, K., Deng, J., Zhang, J., Wang, C., Chen, S., Du, Y., et al. (2014) · Diabetes · doi:10.2337/db13-1689 · Cited by 81 · see citing works
Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation
Drosatos, K., Bharadwaj, K. G., Lymperopoulos, A., Ikeda, S., Khan, R. S., Hu, Y., Agarwal, R., Yu, S., Jiang, H., Steinberg, S. F., et al. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00569.2010 · Cited by 77 · see citing works
Self-citationConcurrent diabetes and heart failure: interplay and novel therapeutic approaches
Karwi, Q. G., Ho, K. L., Pherwani, S., Ketema, E. B., Sun, Q., & Lopaschuk, G. D. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab120 · Cited by 78 · see citing works
Lipotoxicity: a driver of heart failure with preserved ejection fraction?
Leggat, J., Bidault, G., & Vidal‐Puig, A. (2021) · Clinical Science · doi:10.1042/cs20210127 · Cited by 74 · see citing works
Dual PPARα/γ activation inhibits SIRT1-PGC1α axis and causes cardiac dysfunction
Kalliora, C., Kyriazis, I. D., Oka, S., Lieu, M., Yue, Y., Área-Gómez, E., Pol, C. J., Tian, Y., Mizushima, W., Chin, A., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.129556 · Cited by 75 · see citing works
Self-citationContribution of Impaired Insulin Signaling to the Pathogenesis of Diabetic Cardiomyopathy
Zamora, M., & Villena, J. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112833 · Cited by 74 · see citing works
Cardiac Hypertrophy: From Pathophysiological Mechanisms to Heart Failure Development
Caturano, A., Vetrano, E., Galiero, R., Salvatore, T., Docimo, G., Epifani, R., Alfano, M., Sardu, C., Marfella, R., Rinaldi, L., et al. (2022) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2305165 · Cited by 76 · see citing works
Cardiac nuclear receptors: architects of mitochondrial structure and function
Vega, R. B., & Kelly, D. P. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88888 · Cited by 71 · see citing works
Updating Experimental Models of Diabetic Cardiomyopathy
Fuentes‐Antrás, J., Picatoste, B., Gómez‐Hernández, A., Egido, J., Tuñón, J., & Lorenzo, Ó. (2015) · Journal of Diabetes Research · doi:10.1155/2015/656795 · Cited by 72 · see citing works
Moreno, M., Silvestri, E., De Matteis, R., de Lange, P., Lombardi, A., Glinni, D., Senese, R., Cioffi, F., Salzano, A. M., Scaloni, A., et al. (2011) · The FASEB Journal · doi:10.1096/fj.11-181982 · Cited by 71 · see citing works
McCoin, C. S., Knotts, T. A., Ono‐Moore, K. D., Oort, P. J., & Adams, S. H. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00602.2014 · Cited by 71 · see citing works
Pulinilkunnil, T., Kienesberger, P. C., Nagendran, J., Sharma, N., Young, M. E., & Dyck, J. R. B. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.103 · Cited by 70 · see citing works
Genetic loss of insulin receptors worsens cardiac efficiency in diabetes
Bugger, H., Riehle, C., Jaishy, B. P., Wende, A. R., Tuinei, J., Chen, D., Soto, J. E., Pires, K. M. P., Boudina, S., Theobald, H. A., et al. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.02.001 · Cited by 64 · see citing works
Self-citationOrigins of metabolic complications in obesity
Carobbio, S., Rodríguez‐Cuenca, S., & Vidal‐Puig, A. (2011) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32834ad966 · Cited by 64 · see citing works
Frazier, R., Mehta, R., Cai, X., Lee, J., Napoli, S., Craven, T., Tuazon, J., Safdi, A., Scialla, J., Susztak, K., et al. (2019) · Kidney International Reports · doi:10.1016/j.ekir.2018.09.006 · Cited by 63 · see citing works
Kienesberger, P. C., Pulinilkunnil, T., Nagendran, J., Young, M. E., Bogner‐Strauß, J. G., Hackl, H., Khadour, R., Ulrich, E. H., Haemmerle, G., Zechner, R., et al. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt124 · Cited by 61 · see citing works
Targeting metabolic disturbance in the diabetic heart
Fuentes‐Antrás, J., Picatoste, B., Ramírez, E., Egido, J., Tuñón, J., & Lorenzo, Ó. (2015) · Cardiovascular Diabetology · doi:10.1186/s12933-015-0173-8 · Cited by 59 · see citing works
Joseph, L. C., Subramanyam, P., Radlicz, C., Trent, C. M., Iyer, V., Colecraft, H. M., & Morrow, J. P. (2016) · Heart Rhythm · doi:10.1016/j.hrthm.2016.05.002 · Cited by 60 · see citing works
PPARγ deacetylation dissociates thiazolidinedione’s metabolic benefits from its adverse effects
Kraakman, M. J., Liu, Q., Postigo-Fernandez, J., Ji, R., Kon, N., Larrea, D., Namwanje, M., Fan, L., Chan, M., Área-Gómez, E., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci98709 · Cited by 60 · see citing works
Kuo, H.-T., Lin, T.-H., Chen, W.-L., & Lee, H.-M. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.07.028 · Cited by 59 · see citing works
Increased Expression of Fatty-Acid and Calcium Metabolism Genes in Failing Human Heart
García‐Rúa, V., Otero, M. F., Lear, P., Rodríguez‐Penas, D., Feijóo‐Bandín, S., Noguera-Moreno, T., Calaza, M., Álvarez‐Barredo, M., Mosquera‐Leal, A., Parrington, J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037505 · Cited by 59 · see citing works
Peng, L., Baysa, A., Nebb, H. I., Valen, G., Skomedal, T., Osnes, J. B., Yang, Z., & Haugen, F. (2012) · Basic Research in Cardiology · doi:10.1007/s00395-012-0323-z · Cited by 57 · see citing works
Myocardial Metabolism in Diabetic Cardiomyopathy: Potential Therapeutic Targets
Sung, M. M. Y., Hamza, S. M., & Dyck, J. R. B. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6305 · Cited by 57 · see citing works
Using metabolomics to assess myocardial metabolism and energetics in heart failure
Turer, A. T. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.08.025 · Cited by 56 · see citing works
Kuramoto, K., Sakai, F., Yoshinori, N., Nakamura, T. Y., Wakabayashi, S., Kojidani, T., Haraguchi, T., Hirose, F., & Osumi, T. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00133-14 · Cited by 56 · see citing works
Role of Cardiac Steatosis and Lipotoxicity in Obesity Cardiomyopathy
Zhang, Y., & Ren, J. T. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.164178 · Cited by 55 · see citing works
Metabolic characterization of volume overload heart failure due to aorto-caval fistula in rats
Melenovský, V., Beneš, J., Škaroupková, P., Sedmera, D., Strnad, H., Kolář, M., Vlček, Č., Petrák, J., Beneš, J., Papoušek, F., et al. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-0808-3 · Cited by 52 · see citing works
Cardiomyocyte Aldose Reductase Causes Heart Failure and Impairs Recovery from Ischemia
Son, N.-H., Ananthakrishnan, R., Yu, S., Khan, R. S., Jiang, H., Ji, R., Akashi, H., Li, Q., O’Shea, K. M., Homma, S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046549 · Cited by 50 · see citing works
Self-citationPPARs: Protectors or Opponents of Myocardial Function?
Pol, C. J., Lieu, M., & Drosatos, K. (2015) · PPAR Research · doi:10.1155/2015/835985 · Cited by 50 · see citing works
Zhang, J., Wang, Y., Bao, C., Liu, T., Li, S., Huang, J., Wan, Y., & Li, J. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4228 · Cited by 48 · see citing works
He, J., Quintana, M. T., Sullivan, J., Parry, T. L., Grevengoed, T. J., Schisler, J. C., Hill, J. A., Yates, C. C., Mapanga, R. F., Essop, M. F., et al. (2015) · Cardiovascular Diabetology · doi:10.1186/s12933-015-0252-x · Cited by 45 · see citing works
Kalliora, C., & Drosatos, K. (2020) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000891 · Cited by 43 · see citing works
Lipotoxicity and cardiac dysfunction in mammals andDrosophila
Birse, R. T., & Bodmer, R. (2011) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2011.599830 · Cited by 43 · see citing works
Metabolic Complications in Cardiac Aging
Thomas, S., & Drosatos, K. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.669497 · Cited by 42 · see citing works
Cardiac-specific ablation of ARNT leads to lipotoxicity and cardiomyopathy
Wu, R., Chang, H., Khechaduri, A., Chawla, K., Tran, M., Chai, X., Wagg, C. S., Ghanefar, M., Jiang, X., Bayeva, M., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76737 · Cited by 41 · see citing works
2017 George Lyman Duff Memorial Lecture
Goldberg, I. J. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309666 · Cited by 39 · see citing works
Self-citationImpaired fatty acid oxidation as a cause for lipotoxicity in cardiomyocytes
Haffar, T., Bérubé‐Simard, F., & Bousette, N. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.10.162 · Cited by 40 · see citing works
Myocardial Energy Metabolism in Non-ischemic Cardiomyopathy
Greenwell, A. A., Gopal, K., & Ussher, J. R. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.570421 · Cited by 40 · see citing works
A novel physiological role for cardiac myoglobin in lipid metabolism
Hendgen-Cotta, U. B., Esfeld, S., Coman, C., Ahrends, R., Klein‐Hitpaß, L., Flögel, U., Rassaf, T., & Totzeck, M. (2017) · Scientific Reports · doi:10.1038/srep43219 · Cited by 39 · see citing works
Alla, J. A., Grämer, M., Fu, X., & Quitterer, U. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.702688 · Cited by 37 · see citing works
Targeting ATGL to rescue BSCL2 lipodystrophy and its associated cardiomyopathy
Zhou, H., Lei, X., Yan, Y., Lydic, T. A., Li, J., Weintraub, N. L., Su, H., & Chen, W. (2019) · JCI Insight · doi:10.1172/jci.insight.129781 · Cited by 37 · see citing works
Wu, Q., Xiao, Y., Liu, C., Duan, M., Cai, Z., Xie, S., Yuan, Y., Wu, H., Deng, W., & Tang, Q. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.01.027 · Cited by 36 · see citing works
Wang, D., Ho, E. S., Cotticelli, M. G., Xu, P. J., Napierala, J. S., Hauser, L. A., Напиерала, М., Himes, B. E., Wilson, R. B., Lynch, D. R., et al. (2022) · Journal of Lipid Research · doi:10.1016/j.jlr.2022.100255 · Cited by 36 · see citing works
Transcription Factors Involved in the Development and Prognosis of Cardiac Remodeling
Hong, J., & Zhang, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.828549 · Cited by 35 · see citing works
Mechanism of Obesity-Related Lipotoxicity and Clinical Perspective
Engin, A. B. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-63657-8_5 · Cited by 35 · see citing works
Targeted Metabolic Imaging to Improve the Management of Heart Disease
Osterholt, M., Sen, S., Dilsizian, V., & Taegtmeyer, H. (2012) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2011.11.009 · Cited by 34 · see citing works
Tham, Y. K., Huynh, K., Mellett, N. A., Henstridge, D. C., Kiriazis, H., Ooi, J. Y. Y., Matsumoto, A., Patterson, N. L., Sadoshima, J., Meikle, P. J., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.12.003 · Cited by 34 · see citing works
Integrated Control of Fatty Acid Metabolism in Heart Failure
Li, X., & Bi, X. (2023) · Metabolites · doi:10.3390/metabo13050615 · Cited by 33 · see citing works
Wang, X., West, J. A., Murray, A. J., & Griffin, J. L. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00128 · Cited by 33 · see citing works
Lipids in Liver Disease: Looking Beyond Steatosis
Schwabe, R. F., & Maher, J. J. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.11.004 · Cited by 33 · see citing works
Aksentijević, D., McAndrew, D. J., Karlstaedt, A., Zervou, S., Sebag‐Montefiore, L., Cross, R., Douglas, G., Regitz‐Zagrosek, V., Lopaschuk, G. D., Neubauer, S., et al. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.07.008 · Cited by 31 · see citing works
The emergent role of mitochondrial surveillance in cellular health
Tjahjono, E., Kirienko, D. R., & Kirienko, N. V. (2022) · Aging Cell · doi:10.1111/acel.13710 · Cited by 30 · see citing works
Zhang, Y., Bao, M., Dai, M., Wang, X., He, W., Tan, T., Lin, D., Wang, W., Wen, Y. R., & Zhang, R. (2015) · Cardiovascular Diabetology · doi:10.1186/s12933-015-0234-z · Cited by 30 · see citing works
Lipid droplets in the nervous system: involvement in cell metabolic homeostasis
Zhang, Y., Chen, Y., Zhuang, C., Qi, J., Zhao, R. C., & Wang, J. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01401 · Cited by 30 · see citing works
Gao, J., Liu, X., Wang, B., Xu, H., Xia, Q., Lu, T., & Wang, F. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6643 · Cited by 29 · see citing works
Barbieri, M., Filippo, C. D., Esposito, A., Marfella, R., Rizzo, M. R., D’Amico, M., Ferraraccio, F., Ronza, C. D., Duan, S. Z., Mortensen, R. M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035999 · Cited by 28 · see citing works
Aldose Reductase Acts as a Selective Derepressor of PPARγ and the Retinoic Acid Receptor
Thiagarajan, D., Ananthakrishnan, R., Zhang, J., O’Shea, K. M., Quadri, N., Li, Q., Sas, K. M., Xiao, J., Rosario, R., Pennathur, S., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.086 · Cited by 28 · see citing works
PPARγ in Ischemia-Reperfusion Injury: Overview of the Biology and Therapy
Huang, R., Zhang, C., Wang, X., & Hu, H. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.600618 · Cited by 27 · see citing works
Liu, J., Wang, P., He, L., Li, Y., Luo, J., Cheng, L., Qin, Q., Brako, L. A., Lo, W.-K., Lewis, W., et al. (2011) · PPAR Research · doi:10.1155/2011/372854 · Cited by 27 · see citing works
Plin5, a New Target in Diabetic Cardiomyopathy
Cui, X., Wang, J., Zhang, Y., Wei, J.-L., & Wang, Y. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2122856 · Cited by 25 · see citing works
Lipotoxicity and the Development of Heart Failure: Moving from Mouse to Man
Stanley, W. C., & Recchia, F. A. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.016 · Cited by 25 · see citing works
- Authors
- Son, N.-H., Yu, S., Tuinei, J., Arai, K., Hamai, H., Homma, S., Shulman, G. I., Abel, E. D., & Goldberg, I. J.
- Affiliations
- Columbia University (US)
- Corresponding author
- Goldberg, Ira J.
- Venue
- Journal of Clinical Investigation
- Published
- 2010-10-01
- Volume
- 120
- Issue
- 10
- Pages
- 3443-3454
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC2947216
- OpenAlex
- W2150170148
- Cited by
- 159
- References
- 88
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 6 · 2023: 7 · 2022: 10 · 2021: 9 · 2020: 8 · 2019: 6 · 2018: 10 · 2017: 12 · 2016: 12 · 2015: 13 · 2014: 10 · 2013: 11 · 2012: 21
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL045095, R01HL073029, P50HL077113, U01HL087947, HL73029, HL45095, R37HL045095)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK040936, U24DK059635, U2CDK059635, R24DK085638, P30DK034989, P30DK045735)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- PPARγ, PPARα, fatty acid oxidation, triglyceride synthesis, acylcarnitines, diacylglycerol, ceramide, protein kinase C alpha, PKCδ, endoplasmic reticulum stress, apoptosis, reactive oxygen species, dilated cardiomyopathy, heart failure, metabolic syndrome
- MeSH terms
- Animals, Fatty Acids, Fatty Acids, Nonesterified, Lipids, Mice, Inbred CBA, Mice, Inbred C57BL, Myocardium, Oxidation-Reduction, Triglycerides, Apoptosis, Reactive Oxygen Species, Myocytes, Cardiac, PPAR alpha, PPAR gamma, Lipid Metabolism, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
