Overlap between neurodegenerative disorders

Armstrong, Richard A.; Lantos, Peter L.; Cairns, Nigel J.

doi:10.1111/j.1440-1789.2005.00605.x

Cited by 146Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis Research

Overlap between neurodegenerative disorders

Armstrong, Richard A., Lantos, Peter L., Cairns, Nigel J.·2005·Neuropathology

DOI 10.1111/j.1440-1789.2005.00605.x

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Abstract

Neurodegenerative disorders are characterized by the formation of distinct pathological changes in the brain, including extracellular protein deposits, cellular inclusions, and changes in cell morphology. Since the earliest published descriptions of these disorders, diagnosis has been based on clinicopathological features, namely, the coexistence of a specific clinical profile together with the presence or absence of particular types of lesion. In addition, the molecular profile of lesions has become an increasingly important feature both in the diagnosis of existing disorders and in the description of new disease entities. Recent studies, however, have reported considerable overlap between the clinicopathological features of many disorders leading to difficulties in the diagnosis of individual cases and to calls for a new classification of neurodegenerative disease. This article discusses: (i) the nature and degree of the overlap between different neurodegenerative disorders and includes a discussion of Alzheimer's disease, dementia with Lewy bodies, the fronto‐temporal dementias, and prion disease; (ii) the factors that contribute to disease overlap, including historical factors, the presence of disease heterogeneity, age‐related changes, the problem of apolipoprotein genotype, and the co‐occurrence of common diseases; and (iii) whether the current nosological status of disorders should be reconsidered.

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Authors: Armstrong, R. A., Lantos, P. L., & Cairns, N. J.
Affiliations: Aston University (GB)
King's College London (GB)
Washington University in St. Louis (US)
Corresponding author: Armstrong, Richard A.
ORCID: Armstrong, Richard A.
Venue: Neuropathology
Publisher: Wiley
Published: 2005-04
Volume: 25
Issue: 2
Pages: 111-124
ISSN: 0919-6544 (ISSN-L)
1440-1789
DOI: 10.1111/j.1440-1789.2005.00605.x
OpenAlex: W2088237782
Cited by: 146
References: 151
Citations by year: 2026: 7 · 2025: 10 · 2024: 8 · 2023: 11 · 2022: 5 · 2021: 5 · 2020: 8 · 2019: 7 · 2018: 4 · 2017: 5 · 2016: 8 · 2015: 5 · 2014: 13 · 2013: 1 · 2012: 8
FWCI: 0.73
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Neuropathology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
Keywords: neurodegenerative diseases, disease overlap, Alzheimer's disease, dementia with Lewy bodies, frontotemporal dementia, prion disease, clinicopathological features, disease heterogeneity, disease classification, protein deposits, cellular inclusions
MeSH terms: Brain, Humans, Neurodegenerative Diseases

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Overlap between neurodegenerative disorders

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