Cited by 209Dialysis and Renal Disease ManagementGut microbiota and healthSepsis Diagnosis and Treatment

Gut bacterial translocation is associated with microinflammation in end‐stage renal disease patients

WANG, FEIQIAN, JIANG, HONGLI, SHI, KEHUI, REN, YI, ZHANG, PAN, CHENG, SHAOLI·2012·Nephrology

Abstract

Aim: To investigate whether gut bacteria translocation occurs in end‐stage renal disease patients and contributes to microinflammation in end‐stage renal disease (ESRD). Methods: The subjects were divided into two groups: nondialysed ESRD patients (n = 30) and healthy controls (n = 10). Blood samples from all participants were subjected to bacterial 16S ribosomal DNA amplification and DNA pyrosequencing to determine the presence of bacteria, and the alteration of gut microbiomes were examined with the same methods. High‐sensitive C‐reactive protein and interleukin‐6 were detected. Plasma D‐lactate was tested for gut permeability. Results: Bacterial DNAs were detected in the blood of 20% (6/30) of the ESRD patients. All the observed genera in blood (Klebsiella spp, Proteus spp, Escherichia spp, Enterobacter spp, and Pseudomonas spp) were overgrown in the guts of the ESRD patients. Plasma D‐lactate, High‐sensitive C‐reactive protein, and interleukin‐6 levels were significantly higher in patients with bacterial DNA than those without. The control group showed the same results as that of patients without bacterial DNA. Conclusion: Bacterial translocation occurs in ESRD patients and is associated with microinflammation in end stage renal disease.

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Crossref · 10.1111/j.1440-1797.2012.01647.x

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Authors
WANG, F., JIANG, H., SHI, K., REN, Y., ZHANG, P., & CHENG, S.
Affiliations
  • First Affiliated Hospital of Xi'an Jiaotong University (CN)
  • Xi'an Jiaotong University (CN)
Corresponding author
JIANG, HONGLI
Venue
Nephrology
Publisher
Wiley
Published
2012-10-29
Volume
17
Issue
8
Pages
733-738
ISSN
  • 1320-5358 (ISSN-L)
  • 1440-1797
OpenAlex
W2140999961
Cited by
209
References
32
Citations by year
2026: 8 · 2025: 4 · 2024: 17 · 2023: 18 · 2022: 19 · 2021: 22 · 2020: 24 · 2019: 23 · 2018: 16 · 2017: 13 · 2016: 17 · 2015: 14 · 2014: 9 · 2013: 4
FWCI
6.82
Type
journal article
Language
en
Open access
closed
Locations
  • Nephrology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China
Topics
  • Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
Keywords
gut bacterial translocation, end-stage renal disease, microinflammation, gut microbiota, D-lactate, intestinal permeability, C-reactive protein, interleukin-6, Klebsiella, Proteus, Escherichia, Enterobacter, Pseudomonas, dialysis patients
MeSH terms
Adult, Aged, Bacteria, C-Reactive Protein, Feces, Female, Humans, Inflammation, Kidney Failure, Chronic, Male, Middle Aged, RNA, Ribosomal, 16S, Biomarkers, Interleukin-6, Up-Regulation, Chi-Square Distribution, Case-Control Studies, Sequence Analysis, DNA, Inflammation Mediators, Bacterial Translocation, Lactic Acid, Ribotyping, Gastrointestinal Tract, Metagenome

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