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Cited by 406

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

BONE MORPHOGENETIC PROTEINS IN CLINICAL APPLICATIONS

Gautschi, Oliver P., Frey, Sönke P., Zellweger, René·2007·ANZ Journal of Surgery
DOI 10.1111/j.1445-2197.2007.04175.x
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Abstract

The role of bone morphogenetic proteins (BMPs) in bone healing has been shown in numerous animal models. To date, at least 20 BMPs have been identified, some of which have been shown in vitro to stimulate the process of stem cell differentiation into osteoblasts in human and animal models. Having realized the osteoinductive properties of BMPs and having identified their genetic sequences, recombinant gene technology has been used to produce BMPs for clinical application – most commonly, as alternatives or adjuncts in the treatment of cases in which fracture healing is compromised. BMP‐2 and BMP‐7 are approved for clinical use in open fractures of long bones, non‐unions and spinal fusion. However, despite significant evidence of their potential benefit to bone repair and regeneration in animal and preclinical studies, there is, to date, a dearth of convincing clinical trials. The purpose of this paper is to give a brief overview of BMPs and to critically review the clinical data currently available on the use of BMP‐2 and BMP‐7 in fracture healing.

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Metadata

Authors
Gautschi, O. P., Frey, S. P., & Zellweger, R.
Venue
ANZ Journal of Surgery
Publisher
Wiley
Published
2007-07-17
Volume
77
Issue
8
Pages
626-631
ISSN
  • 1445-1433 (ISSN-L)
  • 1445-2197
DOI
10.1111/j.1445-2197.2007.04175.x
OpenAlex
W2049401592
Cited by
406
References
57
FWCI
17.38
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: BONE MORPHOGENETIC PROTEINS IN CLINICAL APPLICATIONS. https://app.cochat.ai/papers/10.1111/j.1445-2197.2007.04175.x
The paper
Gautschi, O. P., Frey, S. P., & Zellweger, R. (2007). BONE MORPHOGENETIC PROTEINS IN CLINICAL APPLICATIONS. ANZ Journal of Surgery. https://doi.org/10.1111/j.1445-2197.2007.04175.x

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.