Cited by 459Wound Healing and TreatmentsTissue Engineering and Regenerative MedicineCell Adhesion Molecules Research

Engineering the Growth Factor Microenvironment with Fibronectin Domains to Promote Wound and Bone Tissue Healing

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Martino, Mikaël M., Tortelli, Federico, Mochizuki, Mayumi, Traub, Stephanie, Ben-David, Dror, Kuhn, Gisela A., Müller, Ralph, Livne, Erella +2 more·2011·Science Translational Medicine

Abstract

A multifunctional fibronectin fragment enhances the regenerative effects of growth factors in vivo in animal models of chronic wounds and critical-size bone defects.

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Registry

Crossref · 10.1126/scitranslmed.3002614

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43 of 43 references verified0 citation errors · 0 not checkable

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  • VEGF is crucial for remodeling the vasculature in several regeneration tissues.

    “VEGF is crucial for remodeling the vasculature in several regeneration tissues [62,63].”
  • Covalent attachment of growth factors and recombinant fibronectin fragments into a fibrin scaffold can provide spatiotemporally controlled release and enhance growth factor-matrix interactions, reducing morphogen concentrations required for effective tissue generation.

    “In experimental models of bone or skin repair, it has been shown that covalent attachment of growth factors and recombinant fibronectin fragments into a fibrin scaffold can provide spatiotemporally controlled release of the growth factor and enhance growth factor–matrix interactions that ultimately significantly reduce the morphogen concentrations required for effective tissue generation (142).”

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Authors
Martino, M. M., Tortelli, F., Mochizuki, M., Traub, S., Ben-David, D., Kuhn, G. A., Müller, R., Livne, E., Eming, S. A., & Hubbell, J. A.
Affiliations
  • École Polytechnique Fédérale de Lausanne (CH)
  • University of Cologne (DE)
  • Department of Anatomy and Cell Biology, Faculty of Medicine, Technion-Israel Institute of Technology, 31096 Haifa, Israel.
  • ETH Zurich (CH)
  • Technion – Israel Institute of Technology (IL)
Corresponding author
Hubbell, Jeffrey A.
Venue
Science Translational Medicine
Published
2011-09-14
Volume
3
Issue
100
Pages
100ra89-100ra89
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W2013170875
Cited by
459
References
43
Citations by year
2026: 12 · 2025: 22 · 2024: 24 · 2023: 24 · 2022: 32 · 2021: 28 · 2020: 41 · 2019: 34 · 2018: 33 · 2017: 40 · 2016: 30 · 2015: 43 · 2014: 39 · 2013: 32 · 2012: 20
FWCI
30.14
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords
fibronectin domains, VEGF-A, PDGF-BB, BMP-2, alpha5beta1 integrin, growth factor delivery, chronic wound healing, critical-size bone defect, angiogenesis, diabetic wounds
MeSH terms
Becaplermin, Animals, Bone and Bones, Bone Regeneration, Fibronectins, Platelet-Derived Growth Factor, Wound Healing, Proto-Oncogene Proteins c-sis, Integrin alpha5beta1, Vascular Endothelial Growth Factor A, Regenerative Medicine, Cell Proliferation, Mice, Rats, Bone Morphogenetic Protein 2

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