Engineering the Growth Factor Microenvironment with Fibronectin Domains to Promote Wound and Bone Tissue Healing
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A multifunctional fibronectin fragment enhances the regenerative effects of growth factors in vivo in animal models of chronic wounds and critical-size bone defects.
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VEGF is crucial for remodeling the vasculature in several regeneration tissues.
“VEGF is crucial for remodeling the vasculature in several regeneration tissues [62,63].”
Covalent attachment of growth factors and recombinant fibronectin fragments into a fibrin scaffold can provide spatiotemporally controlled release and enhance growth factor-matrix interactions, reducing morphogen concentrations required for effective tissue generation.
“In experimental models of bone or skin repair, it has been shown that covalent attachment of growth factors and recombinant fibronectin fragments into a fibrin scaffold can provide spatiotemporally controlled release of the growth factor and enhance growth factor–matrix interactions that ultimately significantly reduce the morphogen concentrations required for effective tissue generation (142).”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [142]
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- Authors
- Martino, M. M., Tortelli, F., Mochizuki, M., Traub, S., Ben-David, D., Kuhn, G. A., Müller, R., Livne, E., Eming, S. A., & Hubbell, J. A.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- University of Cologne (DE)
- Department of Anatomy and Cell Biology, Faculty of Medicine, Technion-Israel Institute of Technology, 31096 Haifa, Israel.
- ETH Zurich (CH)
- Technion – Israel Institute of Technology (IL)
- Corresponding author
- Hubbell, Jeffrey A.
- Venue
- Science Translational Medicine
- Published
- 2011-09-14
- Volume
- 3
- Issue
- 100
- Pages
- 100ra89-100ra89
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2013170875
- Cited by
- 459
- References
- 43
- Citations by year
- 2026: 12 · 2025: 22 · 2024: 24 · 2023: 24 · 2022: 32 · 2021: 28 · 2020: 41 · 2019: 34 · 2018: 33 · 2017: 40 · 2016: 30 · 2015: 43 · 2014: 39 · 2013: 32 · 2012: 20
- FWCI
- 30.14
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- fibronectin domains, VEGF-A, PDGF-BB, BMP-2, alpha5beta1 integrin, growth factor delivery, chronic wound healing, critical-size bone defect, angiogenesis, diabetic wounds
- MeSH terms
- Becaplermin, Animals, Bone and Bones, Bone Regeneration, Fibronectins, Platelet-Derived Growth Factor, Wound Healing, Proto-Oncogene Proteins c-sis, Integrin alpha5beta1, Vascular Endothelial Growth Factor A, Regenerative Medicine, Cell Proliferation, Mice, Rats, Bone Morphogenetic Protein 2
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