CoChat
Sign Up
Cited by 48Pituitary Gland Disorders and TreatmentsAdrenal Hormones and DisordersElectrolyte and hormonal disorders

Cushing’s syndrome in a clinic population with diabetes

Newsome, S., Chen, K., Hoang, J., Wilson, J. D., Potter, J. M., Hickman, P. E.·2008·Internal Medicine Journal
DOI 10.1111/j.1445-5994.2007.01434.x
Open this paper in CoChat — free account

Abstract

BACKGROUND: A recent report has suggested that occult Cushing's syndrome (CS) may be present in a significant number of patients with type 2 diabetes mellitus. The aim of this study was to determine whether any patients in our clinic population with diabetes had this condition. METHODS: One hundred and seventy-one consecutive overweight attendees at the diabetic clinic were enrolled in a study to assess the presence of occult CS. The initial screen was with the 1 mg overnight dexamethasone suppression test and follow-up testing, where indicated was with a 24 h collection for urine-free cortisol. RESULTS: Thirty-one of 171 patients had a positive result from the overnight dexamethasone suppression test. Follow-up testing with 24 h urine-free cortisol reduced the number of patients with positive results to 3. Two of these were shown to have alcoholic pseudo-CS. The third patient has had several high urine-free cortisol results, in the presence of normal scans of pituitary and adrenals. He has no stigmata of CS and is being observed. CONCLUSION: Based on the results of our study, there would appear to be little value in screening type 2 diabetics for CS, in the absence of clinical suspicion.

Integrity signals

Registry

Crossref · 10.1111/j.1445-5994.2007.01434.x

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The prevalence of previously unsuspected Cushing syndrome in patients with type 2 diabetes ranges from 0% to 9.4%.

    “The association between DM and CS has been examined in various studies, which have shown a prevalence of previously unsuspected CS in patients with type  DM ranging from % to .% (Table ) (-).”

    From Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management (2017) · cites this paper as [252]

  • Newsome et al. found no subclinical hypercortisolism in 178 diabetic patients using a low-cutoff 1-mg dexamethasone suppression test.

    “By using 1-mg DST as a screening test with a low cutoff in a sample of 178 diabetic patients, Newsome et al. (86) did not find any subject with SH.”

    From Diagnosis and Treatment of Subclinical Hypercortisolism (2011) · cites this paper as [86]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Newsome, S., Chen, K., Hoang, J., Wilson, J. D., Potter, J. M., & Hickman, P. E.
Affiliations
Australian National University (AU)
Corresponding author
Hickman, P. E.
ORCID
Venue
Internal Medicine Journal
Publisher
Wiley
Published
2007-07-23
Volume
38
Issue
3
Pages
178-182
ISSN
  • 1444-0903 (ISSN-L)
  • 1445-5994
DOI
10.1111/j.1445-5994.2007.01434.x
OpenAlex
W2033709422
Cited by
48
References
31
Citations by year
2025: 2 · 2024: 1 · 2021: 2 · 2020: 1 · 2018: 3 · 2017: 7 · 2016: 6 · 2015: 6 · 2014: 1 · 2012: 5
FWCI
1.95
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Internal Medicine Journal (publishedVersion)
  • PubMed (publishedVersion)
  • ANU Open Research (Australian National University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
Keywords
Cushing's syndrome, type 2 diabetes, dexamethasone suppression test, 24-hour urine free cortisol, screening, overweight patients
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Cushing Syndrome, Dexamethasone, Diabetes Mellitus, Type 2, Female, Humans, Hydrocortisone, Male, Middle Aged, Prospective Studies, Prevalence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review