Late-night salivary cortisol as a screening test for cushing's syndrome
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Various methods to measure salivary cortisol result in different reference ranges and differences in sensitivity and specificity.
“Various methods have been used to measure cortisol in the saliva, resulting in different reference ranges and yielding differences in sensitivity and specificity (59 -67).”
From The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline. (2008) · cites this paper as [64]
Late-night salivary cortisol levels yield a 92-100% sensitivity and a 93-100% specificity for the diagnosis of Cushing's syndrome.
“Using a variety of assays and diagnostic criteria, investigators from different countries have reported that late-night salivary cortisol levels yield a 92-100% sensitivity and a 93-100% specificity for the diagnosis of Cushing's syndrome (59 -67).”
From The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline. (2008) · cites this paper as [64]
LNSC is well-established as a first-line screening test for patients with CS.
“LNSC is well-established as a first-line screening test for patients with CS (7–10).”
From The diagnostic value of salivary cortisol and salivary cortisone in patients with suspected hypercortisolism (2022) · cites this paper as [7]
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The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline.
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“Finally, stress immediately before the collection also may increase salivary cortisol physiologically; therefore, ideally, samples should be collected on a quiet evening at home (64).”
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Pundir, M., Papagerakis, S. M., Rosa, M. C. D., Chronis, N., Kurabayashi, K., Abdulmawjood, S., Prince, M. E. P., Lobanova, L., Chen, D., & Papagerakis, P. (2022) · Biotechnology Advances · doi:10.1016/j.biotechadv.2022.107961 · Cited by 44 · see citing works
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Late-night Salivary Cortisol as A Screening Test for the Diagnosis of Cushing's Syndrome in Japan
Doi, M., Sekizawa, N., Tani, Y., Tsuchiya, K., Kouyama, R., Tateno, T., Izumiyama, H., Yoshimoto, T., & Hirata, Y. (2008) · Endocrine Journal · doi:10.1507/endocrj.k07e-023 · Cited by 40 · see citing works
Variability of late-night salivary cortisol in Cushing disease: a prospective study
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Diagnostic value of salivary cortisol in Cushing's syndrome (CS)
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- Authors
- Raff, H.
- Corresponding author
- Raff, H.
- ORCID
- Raff, H.
- Venue
- Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1998-08-01
- Volume
- 83
- Issue
- 8
- Pages
- 2681-2686
- ISSN
- 0021-972X (ISSN-L)
- OpenAlex
- W4248166725
- Cited by
- 194
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 8 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 6 · 2013: 8 · 2012: 14
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Keywords
- Cushing's syndrome, salivary cortisol, screening test, hypercortisolism
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