Cited by 25Endometriosis Research and TreatmentEndometrial and Cervical Cancer TreatmentsUterine Myomas and Treatments

Malignant transformation of abdominal wall endometriosis: A systematic review of the epidemiology, diagnosis, treatment, and outcomes

Liu, Gang, Wang, Yizi, Chen, Yinghan, Ren, Fang·2021·European Journal of Obstetrics & Gynecology and Reproductive Biology

Abstract

Malignant transformation of abdominal wall endometriosis (AWE) is rare. The clinical characteristics and treatment of malignant transformation of AWE are not well known. Therefore, in this review, we performed a thorough search for malignant transformation of AWE on MEDLINE and Web of Science from their inception to May 2021. In total, the data of 46 patients with malignant transformation of AWE were retrieved, and all the data on these patients were collected. After reviewing and analyzing the clinical parameters, we found that cesarean scar was the most common site of malignant transformation of AWE, and the most common pathological type of malignant transformation of AWE was clear cell cancer, followed by endometrioid adenocarcinoma. The main symptoms of malignant transformation of AWE included an abdominal nodule or mass, and ultrasonography was the first choice for diagnosis. The most widely accepted treatment was surgical resection of local lesions with adjunctive chemotherapy and/or radiotherapy, and the overall survival of patients with malignant transformation of AWE was poor. In conclusion, malignant transformation of AWE is rare, and the prognosis is poor. Thus, improving abdominal surgical technology and avoiding iatrogenic ectopia and implantation of the endometrium are necessary to prevent malignant transformation of AWE.

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Crossref · 10.1016/j.ejogrb.2021.08.006

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Authors
Liu, G., Wang, Y., Chen, Y., & Ren, F.
Affiliations
Sheng Jing Hospital (CN)
Corresponding author
Ren, Fang
Venue
European Journal of Obstetrics & Gynecology and Reproductive Biology
Publisher
Elsevier BV
Published
2021-09
Volume
264
Pages
363-367
ISSN
  • 0028-2243 (ISSN-L)
  • 0301-2115
OpenAlex
W3191729736
Cited by
25
References
67
Citations by year
2026: 3 · 2025: 10 · 2024: 7 · 2023: 3 · 2022: 1 · 2021: 1
FWCI
0.49
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Obstetrics & Gynecology and Reproductive Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81501235)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
  • Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
Keywords
abdominal wall endometriosis, malignant transformation, endometrioid carcinoma, clear cell carcinoma, cesarean section scar, ultrasonography, surgical resection, chemotherapy, radiotherapy, prognosis, endometrial implantation
MeSH terms
Cesarean Section, Cicatrix, Endometriosis, Female, Humans, Pregnancy, Carcinoma, Endometrioid, Abdominal Wall

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