Malignant transformation of abdominal wall endometriosis: A systematic review of the epidemiology, diagnosis, treatment, and outcomes
Abstract
Malignant transformation of abdominal wall endometriosis (AWE) is rare. The clinical characteristics and treatment of malignant transformation of AWE are not well known. Therefore, in this review, we performed a thorough search for malignant transformation of AWE on MEDLINE and Web of Science from their inception to May 2021. In total, the data of 46 patients with malignant transformation of AWE were retrieved, and all the data on these patients were collected. After reviewing and analyzing the clinical parameters, we found that cesarean scar was the most common site of malignant transformation of AWE, and the most common pathological type of malignant transformation of AWE was clear cell cancer, followed by endometrioid adenocarcinoma. The main symptoms of malignant transformation of AWE included an abdominal nodule or mass, and ultrasonography was the first choice for diagnosis. The most widely accepted treatment was surgical resection of local lesions with adjunctive chemotherapy and/or radiotherapy, and the overall survival of patients with malignant transformation of AWE was poor. In conclusion, malignant transformation of AWE is rare, and the prognosis is poor. Thus, improving abdominal surgical technology and avoiding iatrogenic ectopia and implantation of the endometrium are necessary to prevent malignant transformation of AWE.
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The probability of developing endometriosis on an abdominal surgical scar is 0.03% to 1%.
“The probability of developing endometriosis on an abdominal surgical scar is 0.03% to 1% [13,14].”
From Malignancy in Abdominal Wall Endometriosis: Is There a Way to Avoid It? A Systematic Review (2024) · cites this paper as [14]
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- Authors
- Liu, G., Wang, Y., Chen, Y., & Ren, F.
- Affiliations
- Sheng Jing Hospital (CN)
- Corresponding author
- Ren, Fang
- Venue
- European Journal of Obstetrics & Gynecology and Reproductive Biology
- Publisher
- Elsevier BV
- Published
- 2021-09
- Volume
- 264
- Pages
- 363-367
- ISSN
- 0028-2243 (ISSN-L)
- 0301-2115
- OpenAlex
- W3191729736
- Semantic Scholar
- 19c7444cfbdd9f5f891feeff46cecd7431f95c9b
- Cited by
- 25
- References
- 67
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 7 · 2023: 3 · 2022: 1 · 2021: 1
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- European Journal of Obstetrics & Gynecology and Reproductive Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81501235)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
- Keywords
- abdominal wall endometriosis, malignant transformation, endometrioid carcinoma, clear cell carcinoma, cesarean section scar, ultrasonography, surgical resection, chemotherapy, radiotherapy, prognosis, endometrial implantation
- MeSH terms
- Cesarean Section, Cicatrix, Endometriosis, Female, Humans, Pregnancy, Carcinoma, Endometrioid, Abdominal Wall
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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