The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Learning deficit in BDNF mutant mice.
Abstract
Brain-derived neurotrophic factor (BDNF) has been implicated in the regulation of high-frequency synaptic transmission and long-term potentiation in the hippocampus, processes that are also thought to be involved in the learning of spatial tasks such as the Morris water maze. In order to determine whether BDNF is required for normal spatial learning, mice carrying a deletion in one copy of the BDNF gene were subjected to the Morris water maze task. Young adult BDNF mutant mice were significantly impaired compared with wild-type mice, requiring twice the number of days to reach full performance. Aged wild-type mice performed significantly worse than young wild-type mice and the effect was even more pronounced in the BDNF mutant mice, which did not learn at all. Although there was no difference in mean swimming speed between BDNF mutant and wild-type mice, we cannot exclude the possibility that developmental or peripheral deficits also contribute to the learning deficits in these mice. In situ hybridization and RNase protection analysis revealed that BDNF mRNA expression was indeed decreased in BDNF mutant mice. Furthermore, a pronounced effect of age on BDNF mRNA expression was seen, displayed as both a reduced level of mRNA expression and a reduced or entirely absent layer-specific expression pattern in the cerebral cortex of aged animals. Thus, our data suggest that BDNF expression may be linked to learning.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The importance of BDNF to hippocampal neuroplasticity is epitomized by animal studies, which have found that the manipulation of BDNF expression directly impacts upon performance in spatial and contextual memory tasks (Linnarsson et al., 1997; Alonso et al., 2002; Heldt et al., 2007; Peters et al., 2010), and also that the downregulation of BDNF inhibits AE induced improvements in spatial memory”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Linnarsson et al., 1997
Citations
Cites
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Developments of a water-maze procedure for studying spatial learning in the rat
Morris, R. (1984) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(84)90007-4 · Cited by 7,180
Physiology of the Neurotrophins
Lewin, G. R., & Barde, Y. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.001445 · Cited by 1,959
Neurotrophins and Neuronal Plasticity
Thoenen, H. (1995) · Science · doi:10.1126/science.270.5236.593 · Cited by 1,927
Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.
Korte, M., Carroll, P., Wolf, E., Brem, G., Thoenen, H., & Bonhoeffer, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8856 · Cited by 1,426
Long-Lasting Neurotrophin-Induced Enhancement of Synaptic Transmission in the Adult Hippocampus
Kang, H., & Schuman, E. M. (1995) · Science · doi:10.1126/science.7886457 · Cited by 1,354
Patterson, S. L., Abel, T., Deuel, T. A. S., Martin, K. C., Rose, J. C., & Kandel, E. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80140-3 · Cited by 1,233
Figurov, A., Pozzo-Miller, L. D., Olafsson, P., Wang, T., & Lu, B. (1996) · Nature · doi:10.1038/381706a0 · Cited by 1,106
Mice lacking brain-derived neurotrophic factor develop with sensory deficits
Ernfors, P., Lee, K.-F., & Jaenisch, R. (1994) · Nature · doi:10.1038/368147a0 · Cited by 1,067
Self-citationRegional distribution of brain‐derived neurotrophic factor mRNA in the adult mouse brain.
Hofer, M., Pagliusi, S. R., Hohn, A., Leibrock, J., & Barde, Y. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07423.x · Cited by 1,039
Research works printed but not linked: 4
- Blöchl A., 1995, Life and Death in the Newous System, 260
- Galuske R. A. W., 1994, Chronic infusion of brain‐derived neurotrophic factor induces paradoxical ocular dominance shifts in the kitten visual cortex, Soc. Neurosci. Abstc, 20, 312
- Cmesbeck O., 1995, Characterization of brain‐derived neurotrophic factor (BDNF) secretion from hippocampal neumns, Soc. Neurosci. Abstx, 21, 417.12
- Purves D., 1988, A Trophic Theory of Neuronal Organization
Cited by
Sorted by citations
Items 201–300 of 470
Soule, J. D., Penke, Z., Kanhema, T., Alme, M. N., Laroche, S., & Bramham, C. R. (2008) · Neural Plasticity · doi:10.1155/2008/269097 · Cited by 74
Mechanisms of Age-Related Cognitive Change and Targets for Intervention: Epigenetics
Kosik, K. S., Rapp, P. R., Raz, N., Small, S. A., Sweatt, J. D., & Tsai, L. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls110 · Cited by 67
Sánchez‐Mora, C., Marta Ribasés, A., Ramos‐Quiroga, J. A., Casas, M., Bosch, R., Boreatti‐Hümmer, A., Heine, M., Jacob, C., Lesch, K., Fasmer, O. B., et al. (2009) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31008 · Cited by 67
Rizzo, S. J. S., & Crawley, J. N. (2017) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-022516-022754 · Cited by 67
Noble, E. E., Mavanji, V., Little, M. R., Billington, C. J., Kotz, C. M., & Wang, C. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.04.006 · Cited by 71
7,8-Dihydroxyflavone improves memory consolidation processes in rats and mice
Bollen, E., Vanmierlo, T., Akkerman, S., Wouters, C., Steinbusch, H. M. W., & Prickaerts, J. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.09.029 · Cited by 60
Ma, L., Wang, D., Zhang, T.-Y., Yu, H. J., Wang, Y., Huang, S., Lee, F. S., & Chen, Z.-Y. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5348-10.2011 · Cited by 66
Developmental effects of 3,4-methylenedioxymethamphetamine: a review
Skelton, M. R., Williams, M. T., & Vorhees, C. V. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282f62c76 · Cited by 64
Halbach, O. V. B. U., Krause, S., Medina, D. L., Sciarretta, C., Minichiello, L., & Unsicker, K. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.08.025 · Cited by 63
Guillin, O., Griffon, N., Bézard, E., Leriche, L., Díaz, J., Gross, C. E., & Sokoloff, P. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.08.096 · Cited by 68
Liu, C., Carvalho, A., & McIntyre, R. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141130204031 · Cited by 61
Melo, C. V., Mele, M., Curcio, M., Comprido, D., Silva, C. G., & Duarte, C. B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053793 · Cited by 64
Increased Hippocampal ProBDNF Contributes to Memory Impairments in Aged Mice
Buhusi, M. C., Etheredge, C., Granholm, A., & Buhusi, C. V. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00284 · Cited by 67
Hellweg, R., Lohmann, P., Huber, R., Kühl, A., & Riepe, M. W. (2006) · Learning & Memory · doi:10.1101/lm.2606 · Cited by 64
Brain Plasticity and Genetic Factors
Pearson‐Fuhrhop, K. M., Kleim, J. A., & Cramer, S. C. (2009) · Topics in Stroke Rehabilitation · doi:10.1310/tsr1604-282 · Cited by 65
Schrott, L. M., Franklin, L. M., & Serrano, P. A. (2008) · Brain Research · doi:10.1016/j.brainres.2008.01.020 · Cited by 65
Genetic increase in brain-derived neurotrophic factor levels enhances learning and memory
Nakajo, Y., Miyamoto, S., Nakano, Y., Xue, J.-H., Hori, T., & Yanamoto, H. (2008) · Brain Research · doi:10.1016/j.brainres.2008.08.080 · Cited by 62
Jourdi, H., Iwakura, Y., Narisawa‐Saito, M., Ibaraki, K., Xiong, H., Watanabe, M., Hayashi, Y., Takei, N., & Nawa, H. (2003) · Developmental Biology · doi:10.1016/j.ydbio.2003.07.008 · Cited by 63
Grau, J. W., Huie, J. R., Lee, K. H., Hoy, K. C., Huang, Y.-J., Turtle, J. D., Strain, M. M., Baumbauer, K. M., Miranda, R. M., Hook, M. A., et al. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00100 · Cited by 64
Frontal Cortex Epigenetic Dysregulation During the Progression of Alzheimer’s Disease
Mahady, L. J., Nadeem, M., Malek‐Ahmadi, M. H., Chen, K., Perez, S. E., & Mufson, E. J. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-171032 · Cited by 61
Association of peripheral BDNF level with cognition, attention and behavior in preschool children
Yeom, C., Park, Y. H., Choi, S., & Bhang, S. (2016) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/s13034-016-0097-4 · Cited by 63
Role of Neurotrophic Factors in Behavioral Processes
Pardon, M. (2010) · Vitamins and hormones · doi:10.1016/s0083-6729(10)82010-2 · Cited by 60
Yanamoto, H., Xue, J.-H., Miyamoto, S., Nagata, I., Nakano, Y., Murao, K., & Kikuchi, H. (2004) · Brain Research · doi:10.1016/j.brainres.2004.05.105 · Cited by 60
Hidaka, N., Suemaru, K., Takechi, K., Li, B., & Araki, H. (2011) · PubMed · doi:10.18926/amo/46853 · Cited by 58
Fujihara, H., Sei, H., Morita, Y., Ueta, Y., & Morita, K. (2003) · Journal of Molecular Neuroscience · doi:10.1385/jmn:21:3:223 · Cited by 57
Hippocampal dysfunction during the chronic phase following a single exposure to cranial irradiation
Son, Y., Yang, M., Kim, J., Kim, J., Kim, S., Kim, J.-C., Shin, T., Wang, H., Jo, S., Jung, U., et al. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.01.018 · Cited by 60
Cirulli, F., Berry, A., & Alleva, E. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01173-3 · Cited by 57
Li, S., Chicherio, C., Nyberg, L. H., von Oertzen, T., Nagel, I. E., Papenberg, G., Sander, T., Heekeren, H. R., Lindenberger, U., & Bäckman, L. (2009) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21374 · Cited by 56
Peroxiredoxin II preserves cognitive function against age-linked hippocampal oxidative damage
Kim, S., Jin, M.-H., Kim, Y. S., Lee, S., Cho, Y. S., Cho, K.-J., Lee, K., Kim, Y. I., Kim, G. W., Kim, J., et al. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.05.017 · Cited by 56
Genetic Influences on Neural Plasticity
Pearson‐Fuhrhop, K. M., & Cramer, S. C. (2010) · PM&R · doi:10.1016/j.pmrj.2010.09.011 · Cited by 59
Zheng, F., Luo, Y.-N., & Wang, H.-B. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.21863 · Cited by 63
Dean, C., Liu, H., Staudt, T., Stahlberg, M. A., Vingill, S., Bückers, J., Kamin, D., Engelhardt, J., Jackson, M. B., Hell, S. W., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4515-11.2012 · Cited by 58
Zou, Y., Wang, Y., Liu, P., Feng, X.-L., Wang, B., Zang, T., Yu, X., Wei, J., Liu, Z., Liu, Y., et al. (2009) · Neuropsychobiology · doi:10.1159/000265132 · Cited by 57
Brain‐Derived Neurotrophic Factor in Schizophrenia and Its Relation With Dopamine
Guillin, O., Demily, C., & Thibaut, F. (2007) · International review of neurobiology · doi:10.1016/s0074-7742(06)78012-6 · Cited by 57
Caloric restriction does not reverse aging-related changes in hippocampal BDNF
Newton, I. G., Forbes, M. E., Legault, C., Johnson, J. E., Brunso‐Bechtold, J. K., & Riddle, D. R. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.06.005 · Cited by 55
Keifer, J. (2022) · Journal of Neuroscience Research · doi:10.1002/jnr.25022 · Cited by 57
Non-alcoholic fatty liver disease impairs hippocampal-dependent memory in male rats
Ross, A. P., Bruggeman, E. C., Kasumu, A. W., Mielke, J. G., & Parent, M. B. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.01.008 · Cited by 53
Genetic analysis of BDNF and TrkB gene polymorphisms in Alzheimer?s disease
Veps�l�inen, S., Ċastrén, E., Helisalmi, S., Iivonen, S., Mannermaa, A., Lehtovirta, M., H�nninen, T., Soininen, H., & Hiltunen, M. O. (2005) · Journal of Neurology · doi:10.1007/s00415-005-0667-5 · Cited by 52
Neurobiology of Memory and Anxiety: From Genes to Behavior
Kalueff, A. V. (2007) · Neural Plasticity · doi:10.1155/2007/78171 · Cited by 54
Increased Expression of BDNF and Proliferation of Dentate Granule Cells After Bacterial Meningitis
Tauber, S. C., Stadelmann, C., Spreer, A., Brück, W., Nau, R., & Gerber, J. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000178853.21799.88 · Cited by 52
FTO affects hippocampal function by regulation of BDNF processing
Spychala, A., & Rüther, U. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211937 · Cited by 58
Grace, C. E., Schaefer, T. L., Herring, N. R., Skelton, M. R., McCrea, A. E., Vorhees, C. V., & Williams, M. T. (2007) · Synapse · doi:10.1002/syn.20470 · Cited by 52
Sokoloff, P., Guillin, O., Díaz, J., Carroll, P., & Griffon, N. (2002) · Neurotoxicity Research · doi:10.1080/1029842021000045499 · Cited by 55
Pirooznia, S. K., & Elefant, F. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00030 · Cited by 53
Schaaf, M. J. M., Sibug, R. M., Duurland, R., Fluttert, M., Oitzl, M. S., de Kloet, E. R., & Vreugdenhil, E. (1999) · Stress · doi:10.3109/10253899909001121 · Cited by 52
Son, Y., Yang, M., Kang, S., Lee, S., Kim, J., Kim, J., Park, S., Kim, J., Jo, S., Jung, U., et al. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.03.002 · Cited by 48
Ge, J., Xu, Y., Qin, G., Pan, X., Cheng, J., & Chen, F. (2015) · Brain Research · doi:10.1016/j.brainres.2015.10.027 · Cited by 49
Memory consolidation in day-old chicks requires BDNF but not NGF or NT-3; an antisense study
Johnston, A. N. B., & Rose, S. P. R. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00016-x · Cited by 49
Taubenfeld, S. M., Stevens, K. A., Pollonini, G., Ruggiero, J., & Alberini, C. M. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00936.x · Cited by 48
Laing, K. R., Mitchell, D., Wersching, H., Czira, M. E., Berger, K., & Baune, B. T. (2011) · AGE · doi:10.1007/s11357-011-9275-8 · Cited by 48
Zheng, F., & Wang, H. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.01.006 · Cited by 49
Wei, S.-M., Eisenberg, D. P., Kohn, P. D., Kippenhan, J. S., Kolachana, B. S., Weinberger, D. R., & Berman, K. F. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5375-11.2012 · Cited by 47
Gilchrist, C. P., Cumberland, A. L., Walker, D. W., & Tolcos, M. (2018) · The Lancet Child & Adolescent Health · doi:10.1016/s2352-4642(18)30245-1 · Cited by 45
Skelton, M. R., Williams, M. T., & Vorhees, C. V. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0563-4 · Cited by 44
Jain, S., Banerjee, B. D., Ahmed, R. S., Arora, V. K., & Mediratta, P. K. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1122-0 · Cited by 45
Borralleras, C., Sahún, I., Jurado, L. A. P., & Campuzano, V. (2015) · Molecular Therapy · doi:10.1038/mt.2015.130 · Cited by 50
Gene Expression in the Conversion of Early‐Phase to Late‐Phase Long‐Term Potentiation
Lee, P. R., Cohen, J. E., Becker, K. G., & Fields, R. D. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1342.023 · Cited by 44
Costa, R. O., Martins, L. F., Tahiri, E., & Duarte, C. B. (2022) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1713 · Cited by 45
Hwang, I. K., Yoo, K., Jung, B.-K., Cho, J. H., Kim, D., Kang, T., Kwon, Y., Kim, Y., & Won, M. H. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.02.129 · Cited by 45
Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome
Andrade‐Talavera, Y., Benito, I., Casañas, J. J., Moreno, A. R., & Montesinos, M. L. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.09.005 · Cited by 42
Bolto, M. M., Lo, D. C., & Sherwood, N. T. (2000) · Progress in brain research · doi:10.1016/s0079-6123(00)28018-7 · Cited by 42
BDNF controls GABAAR trafficking and related cognitive processes via autophagic regulation of p62
Tomoda, T., Sumitomo, A., Shukla, R., Hirota-Tsuyada, Y., Miyachi, H., Oh, H., French, L., & Sibille, E. L. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01116-0 · Cited by 43
By what molecular mechanisms do social determinants impact cardiometabolic risk?
Baumer, Y., Pita, M. A., Baez, A. S., Ortiz-Whittingham, L. R., Cintron, M., Rose, R., Gray, V. C., Baah, F. O., & Powell‐Wiley, T. M. (2023) · Clinical Science · doi:10.1042/cs20220304 · Cited by 40
Kim, I. H., Park, S. K., Sun, W., Kang, Y., Kim, H. T., & Kim, H. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2003.12.016 · Cited by 40
Diet-induced metabolic disturbances as modulators of brain homeostasis
Zhang, L., Bruce‐Keller, A. J., Dasuri, K., Nguyen, A., Liu, Y., & Keller, J. N. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.09.006 · Cited by 41
Rare Syndromes and Common Variants of the Brain-Derived Neurotrophic Factor Gene in Human Obesity
Han, J. C. (2016) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.12.002 · Cited by 42
Garner, J. M., Chambers, J., Barnes, A., & Datta, S. (2017) · SLEEP · doi:10.1093/sleep/zsx194 · Cited by 44
Skelton, M. R., Williams, M. T., Schaefer, T. L., & Vorhees, C. V. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.05.004 · Cited by 41
Neurotrophins in the dentate gyrus
Binder, D. K. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)63022-2 · Cited by 43
Deibel, S. H., Zelinski, E. L., Keeley, R. J., Kovalchuk, O., & McDonald, R. J. (2015) · Oncotarget · doi:10.18632/oncotarget.4036 · Cited by 40
Brain-Derived Neurotrophic Factor And The Plasticity Of The Mesolimbic Dopamine Pathway
Guillin, O., Griffon, N., Díaz, J., Foll, B. L., Bézard, E., Gross, C. E., Lammers, C., Stark, H., Carroll, P., & Schwartz, J.-C. (2004) · International review of neurobiology · doi:10.1016/s0074-7742(04)59016-5 · Cited by 42
Garoflos, E., Panagiotaropoulos, T. I., Pondiki, S., Stamatakis, A., Philippidis, E., & Stylianopoulou, F. (2005) · Annals of General Psychiatry · doi:10.1186/1744-859x-4-8 · Cited by 39
Differential expression of BDNF mRNA splice variants in mouse brain and immune cells
Kruse, N., Cetin, S., Chan, A., Gold, R., & Lühder, F. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.09.001 · Cited by 40
Analyzing the influence of BDNF heterozygosity on spatial memory response to 17β-estradiol
Wu, Y., Du, X., van den Buuse, M., & Hill, R. (2015) · Translational Psychiatry · doi:10.1038/tp.2014.143 · Cited by 39
Epigenetic suppression of hippocampal BDNF mediates the memory deficiency induced by amyloid fibrils
Wang, B., Zhong, Y., Zhao, Z., & Miao, Y. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.09.009 · Cited by 36
Reliable Biomarkers and Predictors of Schizophrenia and its Treatment
Pillai, A., & Buckley, P. F. (2012) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2012.06.006 · Cited by 35
TrkB but not trkC receptors are necessary for postnatal maintenance of hippocampal spines
von Bohlen und Halbach, O., Minichiello, L., & Unsicker, K. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.02.028 · Cited by 37
Morphine-responsive neurons that regulate mechanical antinociception
Fatt, M. P., Zhang, M.-D., Kupari, J., Altınkök, M., Yang, Y., Hu, Y., Svenningsson, P., & Ernfors, P. (2024) · Science · doi:10.1126/science.ado6593 · Cited by 35
Impact of an additional chronic BDNF reduction on learning performance in an Alzheimer mouse model
Psotta, L., Rockahr, C., Gruß, M., Kirches, E., Braun, K., Leßmann, V., Bock, J., & Endres, T. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00058 · Cited by 35
Differential gene expression in the rat hippocampus during learning of an operant conditioning task
Rapanelli, M., Frick, L. R., & Zanutto, B. S. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.07.037 · Cited by 34
Dahlström, M., Madjid, N., Nordvall, G., Halldin, M. M., Vazquez-Juarez, E., Lindskog, M., Sandin, J., Winblad, B., Eriksdotter, M., & Forsell, P. (2021) · Cells · doi:10.3390/cells10081871 · Cited by 33
Sucrose-induced analgesia during early life modulates adulthood learning and memory formation
Nuseir, K. Q., Alzoubi, K. H., Alabwaini, J., Khabour, O. F., & Kassab, M. I. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.04.002 · Cited by 33
Loss of Neuroprotective Factors in Neurodegenerative Dementias: The End or the Starting Point?
Benussi, L., Binetti, G. G., & Ghidoni, R. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00672 · Cited by 35
Finan, J. D., Udani, S., Patel, V. A., & Bailes, J. E. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180585 · Cited by 36
Ozawa, T., Yamada, K., & Ichitani, Y. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.01.034 · Cited by 31
bdnf loss affects activity, sociability, and anxiety-like behaviour in zebrafish
Lucon‐Xiccato, T., Tomain, M., D’Aniello, S., & Bertolucci, C. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114115 · Cited by 31
Kim, S. J., Cho, S., Jang, H. M., Shin, J., Park, P.-W., Lee, Y. J., Cho, I. H., Choi, J.-E., & Lee, H. (2009) · Neuropsychobiology · doi:10.1159/000258639 · Cited by 31
Moro, A., van Woerden, G. M., Toonen, R. F. G., & Verhage, M. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000826 · Cited by 32
Zheng, F., Soellner, D., Nuñez, J. L., & Wang, H. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05478.x · Cited by 31
Effect of quercetin on the brain-derived neurotrophic factor gene expression in the rat brain
Rahvar, M., Owji, A. A., & Mashayekhi, F. J. (2018) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.4149/bll_2018_006 · Cited by 31
Kao, P. F., Banigan, M. G., Vanderburg, C. R., McKee, A. C., Polgar, P. R., Seshadri, S., & Delalle, I. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31825d06b7 · Cited by 31
Şimşek, Ş., Uysal, C., Kaplan, İ., Yüksel, T., & Aktaş, H. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.02.017 · Cited by 32
Morıchı, S., Kashiwagi, Y., Takekuma, K., Hoshika, A., & Kawashima, H. (2012) · International Journal of Neuroscience · doi:10.3109/00207454.2012.721829 · Cited by 30
Sansevero, G., Begenisic, T., Mainardi, M., & Sale, A. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.06.006 · Cited by 31
Wu, B., Wang, Y., Shi, C., Chen, Y., Yu, L., Li, J., Li, W., Yan, W., & He, R. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190158 · Cited by 30
Itoh, N., Enomoto, A., Nagai, T., Takahashi, M., & Yamada, K. (2016) · Reviews in the Neurosciences · doi:10.1515/revneuro-2015-0072 · Cited by 31
Predicting relapse in schizophrenia: Is BDNF a plausible biological marker?
Pillai, A., Schooler, N. R., Peter, D., Looney, S. W., GOFF, D. C., Kopelowicz, A. J., Lauriello, J., Manschreck, T. C., Mendelowitz, A. J., Miller, D. D., et al. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.06.059 · Cited by 31
Amagase, Y., Kambayashi, R., Sugiyama, A., & Takei, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043543 · Cited by 33
The Role of the BDNF Val66Met Polymorphism in Recovery of Aphasia After Stroke
de Boer, R. G., Spielmann, K., Heijenbrok‐Kal, M. H., van der Vliet, R., Ribbers, G. M., & van de Sandt‐Koenderman, W. M. E. (2017) · Neurorehabilitation and neural repair · doi:10.1177/1545968317723752 · Cited by 29
Jacobsen, J. P. R., Redrobe, J. P., Hansen, H. H., Petersen, S., Bond, C. T., Adelman, J. P., Mikkelsen, J. D., & Mirza, N. R. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.062 · Cited by 27
Metadata
- Authors
- Linnarsson, S., Björklund, A., & Ernfors, P.
- Affiliations
- Karolinska Institutet (SE)
- Lund University (SE)
- Corresponding author
- Linnarsson, Sten
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 1997-12
- Volume
- 9
- Issue
- 12
- Pages
- 2581-2587
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2136761139
- Cited by
- 471
- References
- 44
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 12 · 2022: 10 · 2021: 9 · 2020: 11 · 2019: 12 · 2018: 9 · 2017: 16 · 2016: 20 · 2015: 25 · 2014: 25 · 2013: 29 · 2012: 30
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cancerfonden
- Vetenskapsrådet
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- brain-derived neurotrophic factor, BDNF knockout mice, spatial learning, Morris water maze, hippocampus, long-term potentiation, synaptic transmission, BDNF mRNA expression, age-related decline, cerebral cortex, learning deficits
- MeSH terms
- Age Factors, Animals, Mice, Inbred BALB C, Mice, Neurologic Mutants, Retention, Psychology, RNA, Messenger, Spatial Behavior, Long-Term Potentiation, Gene Expression Regulation, Developmental, Maze Learning, Brain-Derived Neurotrophic Factor, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
